tylenol

[Guest guest]

-----Original Message-----

From: Leona Just a year

after my surgery I was diagnosed with PSC. Could there be a link

Who

knows, I’m not a doctor, but I doubt it. I don’t think the liver injury

people get from a Tylenol overdose is the same as PSC. Don’t think they have the bile duct

problems, but go straight to cirrhosis.

Also, Ken has never taken a Tylenol and he has PSC. But again I’m not a doctor so

could be wrong about this.

-Barb in Texas - Son Ken (30) UC 91 & PSC 99

[Guest guest]

Hi Leona;

I agree with Barb that it is probably not related.

The following article goes into great detail about drug-induced

liver disease, and Table 5 of this article indicates that

acetaminophen can cause massive necrosis resembling fulminant

hepatitis. As Barb mentioned, it would not cause the characteristic

bile-duct injury seen in PSC.

http://merck.micromedex.com/index.asp?

page=bpm_brief & article_id=CPM02HP373

(you might have to cut and paste these two lines of the URL into

your browser address bar to take you to this article).

Best regards,

Dave

> My GI has told me to take Tylenol for pain when needed which I do

but not all the time.Scared to take pain killers and usually suffer

it out.

> Now when I read all this information about Tylenol makes me

wonder. I have osteoarthritis and for years prior to having my hip

surgery lived on Tylenol and Tylenol 3 along with anti-inflammatory

pills. Just a year after my surgery I was diagnosed with PSC. Could

there be a link

> Leona

[Guest guest]

From what I understand, the end result is the same in reguards to

the liver damage. They both result in liver failure. You can also

see the same type of rise in your liver enzymes. Typically with the

tylenol liver damage your ALT and AST go up. Your GGT may also go

up, but it is very sensitive to so many things that the doctors do

not pay much attention to it. The ratio of AST/ALT is about 0.5

(for tylenol). My ALT and AST were the first enzymes to go up so

they were investigating tylenol as a possible cause however my ALT

was higher than my AST which eliminated tylenol. There is a lot of

research out there on Tylenol and its relation to liver failure if

you are interested. I hope this helps.

> > My GI has told me to take Tylenol for pain when needed which I

do

> but not all the time.Scared to take pain killers and usually

suffer

> it out.

> > Now when I read all this information about Tylenol makes me

> wonder. I have osteoarthritis and for years prior to having my hip

> surgery lived on Tylenol and Tylenol 3 along with anti-

inflammatory

> pills. Just a year after my surgery I was diagnosed with PSC.

Could

> there be a link

> > Leona

[Guest guest]

Now when I read all this information about Tylenol makes me wonder. I

have osteoarthritis and for years prior to having my hip surgery

lived on Tylenol and Tylenol 3 along with anti-inflammatory pills.

Just a year after my surgery I was diagnosed with PSC. Could there

be a link

Leona

*****

Leona,

I lived on Excedrin for pain, but I doubt that it triggered my PSC.

Stress might have something to do with it though.

Take a look at the article I posted earlier. Message no. 64323

Andi

[Guest guest]

Thanks all for your input. Feel better that this probably wasn't caused by all the tylenol I was taking. When you go for a number of years with bone rubbing on bone, which happens in cases like mine, and you are in constant pain you take what you have to for some temporary relief.

What a wonderful group this is. you must spend hours researching everything.

Leona