Re: Mifepristone from a

[Guest guest]

Miriam,

did you notice any change in your fibroids since the study?

a

Miriam Goodman wrote: I got Mifepristone in conjunction

with the second study done - the low dose

study - which began, for me, in January of 2001. It was designed to be 6

months only, so you are correct, I do not believe that there is a current

study. I have been wondering, though, about the status of the quest to have

Mifepristone approved for shrinking fibroids.

Re: re: Mifepristone from a

>

> Hi

> Yes Mifepristone (RU486) is used to terminate pregnancies. How long ago

did you participate in the study, and who was conducting it? From what I

understand, there may not be a cuurent clinical trial in progress. If you

know differently, please let me know.

> Thanks, a

> NPacer123@... wrote: Hi - I live in Rochester & participated in the

first interview for the

> mifepristone study. When I read the side effects - including possible

early

> abortion - I decided not to continue.

>

[Guest guest]

a-

For various reasons, my data wasn't used so I wasn't measured in the study

itself. I did notice a change, almost immediatelly and I would swear that

they did get smaller. However, after a year, either they grew again or

others grew. And now, it's all academic anyway!

BTW, I too am in Los Angeles. I haven't heard of anyone doing a study here,

but there was a study done in the past at UC San Diego, and I believe that

there may be another one there in the future. The people at Rochester told

me something to the effect that the researcher at UCSD was getting funding

for a new study.

Miriam

Re: re: Mifepristone from a

>

> Miriam,

> did you notice any change in your fibroids since the study?

> a

> Miriam Goodman wrote: I got Mifepristone in

conjunction with the second study done - the low dose

> study - which began, for me, in January of 2001. It was designed to be 6

> months only, so you are correct, I do not believe that there is a current

> study. I have been wondering, though, about the status of the quest to

have

> Mifepristone approved for shrinking fibroids.

>

>

[Guest guest]

I'm not sure what you mean about there not being a clinical trial in

progress.

The study was from Dr. Schaff at the University of Rochester, affiliated

w/Strong Memorial Hospital.

[Guest guest]

Miriam - do you know the name of the researcher at UCSD? As I live

in San Diego, I'm interested in learning more about this potential

new study.

Thanks!

> a-

> For various reasons, my data wasn't used so I wasn't measured in

the study

> itself. I did notice a change, almost immediatelly and I would

swear that

> they did get smaller. However, after a year, either they grew

again or

> others grew. And now, it's all academic anyway!

> BTW, I too am in Los Angeles. I haven't heard of anyone doing a

study here,

> but there was a study done in the past at UC San Diego, and I

believe that

> there may be another one there in the future. The people at

Rochester told

> me something to the effect that the researcher at UCSD was getting

funding

> for a new study.

> Miriam

[Guest guest]

I hope that I'm wrong. I haven't found anyone so far who knows of a current

trial, but I will definitely check out the University of Rochester. Thanks for

the tip.

NPacer123@... wrote: I'm not sure what you mean about there not being a

clinical trial in

progress.

The study was from Dr. Schaff at the University of Rochester, affiliated

w/Strong Memorial Hospital.

[Guest guest]

I wasn't meaning to give you the info as a " tip " , just wanted to answer your

question. Mifespristone is a powerful drug. I'd rather go through a

hysterectomy than take it.

[Guest guest]

In a message dated 6/1/2002 1:20:00 PM Pacific Daylight Time,

NPacer123@... writes:

> I wasn't meaning to give you the info as a " tip " , just wanted to answer your

>

> question. Mifespristone is a powerful drug. I'd rather go through a

> hysterectomy than take it.

>

>

As someone who took 10 mg of mifepristone a day for a year, I don't know what

you're talking about. My fibroids shrunk about 50%; my periods stopped while

I took the drug, giving me a respite from the increasing nightmare each month

was becoming and allowing my body to turn back from the anemia I was

developing; my kidneys, which had become dilated with backed-up urine (a

condition called hydronephrosis), returned to normal as the pressure of the

fibroids subsided. The only major concern I know of about taking the drug is

the possibility of developing hyperplasia (a build-up of the uterine lining

that can develop in an environment of unopposed estrogen), but even this is

treatable. (I didn't develop it.)

After my year in the clinical trial at Rochester was over, my periods

returned, much lighter and shorter than they had been. I don't know (yet) if

my fibroids are growing back; if they are, at least the other symptoms have

not yet returned to trouble me. I bless the day I was accepted into that

study; it allowed me to avoid surgery, something I strongly dread. I hope the

studies bear fruit so that other women can find the relief I did.

[Guest guest]

I would like to have other alternatives besides sugery. I'm only 34 with no

kids, and am planning to have some in the future. If the Mifepristone can safely

and effectively reduce the fibroids, then I'm all for it. Surgery for me is a

very major step, and I don't want the side effects of Lupron. I'm pretty much

asymptomatic, just frequent urination sometimes, and a little pooch, but my

periods are fine and I don't gush blood. So for me I would consider another

alternative.

NPacer123@... wrote: I wasn't meaning to give you the info as a " tip " ,

just wanted to answer your

question. Mifespristone is a powerful drug. I'd rather go through a

hysterectomy than take it.

[Guest guest]

, do you know the ultimate outcome of the study? Are they anywhere in

the approval process? I particpated in the same study in a limited way - I

took 25 mg as a patient for 3 months. However, after that, I had a mildly

elevated liver function test, which could have been caused by anything, and

had to stop taking the Mifepristone.

Miriam

Re: re: Mifepristone from a

> In a message dated 6/1/2002 1:20:00 PM Pacific Daylight Time,

> NPacer123@... writes:

>

>

> > I wasn't meaning to give you the info as a " tip " , just wanted to answer

your

> >

> > question. Mifespristone is a powerful drug. I'd rather go through a

> > hysterectomy than take it.

> >

> >

>

> As someone who took 10 mg of mifepristone a day for a year, I don't know

what

> you're talking about. My fibroids shrunk about 50%; my periods stopped

while

> I took the drug, giving me a respite from the increasing nightmare each

month

> was becoming and allowing my body to turn back from the anemia I was

> developing; my kidneys, which had become dilated with backed-up urine (a

> condition called hydronephrosis), returned to normal as the pressure of

the

> fibroids subsided. The only major concern I know of about taking the drug

is

> the possibility of developing hyperplasia (a build-up of the uterine

lining

> that can develop in an environment of unopposed estrogen), but even this

is

> treatable. (I didn't develop it.)

>

> After my year in the clinical trial at Rochester was over, my periods

> returned, much lighter and shorter than they had been. I don't know (yet)

if

> my fibroids are growing back; if they are, at least the other symptoms

have

> not yet returned to trouble me. I bless the day I was accepted into that

> study; it allowed me to avoid surgery, something I strongly dread. I hope

the

> studies bear fruit so that other women can find the relief I did.

>

>

>

>

>