Guest guest Posted January 1, 1970 Report Share Posted January 1, 1970 Greg, was she familiar with this research before your contact? Has she read the entire article and not just abstract, and therefore know the dosage level the researchers were using(which was within prescribed safe levels)?? Is this Dr Short from the thread about " dr with AN's " , whose meningiomas still produced some merlin therefore she didn't have nf2? ( I think you referred to her as nf2 wannabee). She talked about safety in numbers and how having multiple meningiomas was more rare...... I don't believe she had any schwannomas,except VS ones. I on 6/2/01 10:42 AM, Greg at GREGIERY@... wrote: > Hi Crew, > > I had an intersting conversation with Dr. Short this afternoon on the use of > quinidine as a theraputic treatment for NF2 tumors. I thought this was very > interesting so I bounced a few questions off her to get an idea of what > researches are thinking about this drug. Perhaps you'll find this > interesting: > > Hello Dr. Short, > > would you happen to know more regarding the article below on studies done > using quinidine to interfere with schwannoma tumor growth? > Greg > > Very interesting given that in the adverse effects cited about the use of > quinidine, which is a drug used for cardiac arrythmias..is the syndrome of > cinchonism, which is the symptom complex associated with toxicity > (overdoseage) , includes tinnitus, reversible high frequency hearing loss, and > deafness. So as impressive as the in vitro data.....I don't think that it is > going to be a viable option of therapy for patients with NF2 who are trying to > salvage their hearing....Irony > > Yes, but Dr. Short, if you've already lost your hearing, balance, and have > problems with tinnitus, would this drug be of beneficial use to the user who > say, has an aggressive case of NF2? Do you know if this drug has even been > approved? Does " in vitro " refer to lab studies alone? > Greg > > > You know I was thinking more about the adverse side effects...and it is > probably its effect on normal schwann cells that cause the effect...so it > would mean that there would be a narrow window of efficacy in someone with > hearing. However as you say in your case...that wouldn't be an issue...though > perhaps it might have effects on other cranial nerves...though you may or may > not know that the VIII nerve is interesting in that it is covered by central > myelin (made by oligodendrocytes) and then as it exits the brain by peripheral > myelin producing schwann cells...so maybe it wouldn't be as big an issue for > other cranial nerves. > P > > > > > > Quote Link to comment Share on other sites More sharing options...
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