IgA & Vitamin B12 - any connection?

[Guest guest]

Hi,

I was diagnosed for IgA acouple of years ago. Recently my doctor

found that I also have a vitamin B12 deficiency. Is there any known

connection between the two?

Thanks,

Eldad.

[Guest guest]

Hi Chuck,

You are very fortunate that your IgAN has remained so mild for so many years,

especially in light of the fact that you have struggled with high blood

pressure which can hasten the decline of kidney function.

Thanks for sharing your good news!

[Guest guest]

Chuck,

Boring is good, if it means your IgAN has remained mild. We need more

boredom like that

Pierre

Re: IgA & Vitamin B12 - any connection?

> Yaacob

>

> The details get vague about the early years but when I first diagnosed, my

creatinine clearance was around 1.2 - 1.4 and my proteinura was high but I

don't remember the numbers. I had high blood pressure and the doctor started

me on Coorgard at a very low dose. My proteinura dropped and was never very

high and varied from just over 1mg/ l to as low as .10. At my last check up

it was at 0.35mg/l but apparently my blood count was up significantly ( Not

sure what that means but my doctor has asked my nephrologist to advise ).

For years I continued at a low dosage until 1997/98 when I had to start

taking more medication to keep my blood pressure in check. I was taking as

much as 160mg Coorgard per day. The side effect with such a high dosage was

for me, a lack of energy and always sleepy. I had the doctor put me on

another medication, Norvasc ( amlodipine), about 20 mg per day. Two years

ago I also started taking 25mg of hydrochlorothiazide as well and have very

little side

> effect and so far my blood pressure is around the 120 / 75 range. One

effect of the water pill was that I had to start taking a potassium

supplement.

> My creatine clearance has crept up over the years in a fairly straight

line to about 1.9 with one anomaly that I remember, I had one high result

of 2.2 in 1997.

> Never had a flare up of any sort but I did get the flank pain, not severe

but uncomfortable at times. About 3 years ago I reduced my coffee intake

from 3 or four cups a day to one and this seems to have stopped the flank

pain almost completely. My diet restriction was simple, avoid taking in

too much salt and fatty foods . I am lucky, my disease has so far been

mildy progressive unlike a number of people in this group. I have visited

the same nephrologist only 4-5 times in seventeen years. If it wasn't for

the medication I would forget I had the disease. Hope I wasn't too boring.

>

> Chuck

>

>

[Guest guest]

Hi Pierre,

Got my annual biochemistry report today as follows:

Protein,24 Hr Ur

Protein Urine <0.06 G/L

24Hr Urine Vol 2400 H ML

Protein,24 Hr UR G/DAY (no reading as result not calculated because

concentration of one variable is outside the measuring range)

Potassium 4.2 MMOL/L

Creatinine 113 UMOL/L

My Nepth not of help as he is in hurry to see long line of patients. I could

sense that he is not in mood to answer question.Next visit will be in Sept'04.

Would appreciate if Pierre could interpret for me the results. Thanks in

anticipation.

Yaacob

" Pierre L (groups) " wrote:

Chuck,

Boring is good, if it means your IgAN has remained mild. We need more

boredom like that

Pierre

Re: IgA & Vitamin B12 - any connection?

> Yaacob

>

> The details get vague about the early years but when I first diagnosed, my

creatinine clearance was around 1.2 - 1.4 and my proteinura was high but I

don't remember the numbers. I had high blood pressure and the doctor started

me on Coorgard at a very low dose. My proteinura dropped and was never very

high and varied from just over 1mg/ l to as low as .10. At my last check up

it was at 0.35mg/l but apparently my blood count was up significantly ( Not

sure what that means but my doctor has asked my nephrologist to advise ).

For years I continued at a low dosage until 1997/98 when I had to start

taking more medication to keep my blood pressure in check. I was taking as

much as 160mg Coorgard per day. The side effect with such a high dosage was

for me, a lack of energy and always sleepy. I had the doctor put me on

another medication, Norvasc ( amlodipine), about 20 mg per day. Two years

ago I also started taking 25mg of hydrochlorothiazide as well and have very

little side

> effect and so far my blood pressure is around the 120 / 75 range. One

effect of the water pill was that I had to start taking a potassium

supplement.

> My creatine clearance has crept up over the years in a fairly straight

line to about 1.9 with one anomaly that I remember, I had one high result

of 2.2 in 1997.

> Never had a flare up of any sort but I did get the flank pain, not severe

but uncomfortable at times. About 3 years ago I reduced my coffee intake

from 3 or four cups a day to one and this seems to have stopped the flank

pain almost completely. My diet restriction was simple, avoid taking in

too much salt and fatty foods . I am lucky, my disease has so far been

mildy progressive unlike a number of people in this group. I have visited

the same nephrologist only 4-5 times in seventeen years. If it wasn't for

the medication I would forget I had the disease. Hope I wasn't too boring.

>

> Chuck

>

>

[Guest guest]

Hi Yaacob,

I have had to do some conversions to US units here, but your creatinine level

is very very good. That converts to 1.3 in US units, and that is only

slightly elevated, which means your kidney function is very good.

Your potassium is well within to normal range, so I doubt your doctor will

restrict your dietary potassium, also good news.

The only thing of concern is the protein at 2.4 grams in 24 hours. Ideally

that would be lower, and spilling a high volume of protein isn't all that great

for your kidneys. Your doctor may advise a low protein diet, but please let

me stress do not under any circumstances start any dietary changes until after

being advised to do so by your Nephrologist.

I am not a doctor, but my guess is that your Nephrologist will want to work

on getting your protein level down. It is not extremely high, for instance

mine has been as high as over 10,000 mg/24 hours (over 10 grams) and at 10, my

Nephrologist gets very concerned. If I am under 3 grams now, my Neph if pretty

happy with it.

I hope that helps.