Guest guest Posted June 26, 2003 Report Share Posted June 26, 2003 Hi , Congratulations on the drop in your creatinine! We have really had a run of great news in the group lately, and that is so great. Quote Link to comment Share on other sites More sharing options...
Guest guest Posted June 26, 2003 Report Share Posted June 26, 2003 Well at least it isn't going up. The important thing is the overall trend. It's not that unusual for serum creatinine to vary, since it can be affected by hydration, exercise, the amount of protein eaten or not eaten, nutritional status blood pressure medications, the lab used if not always the same and the process (there are two major ways of doing serum creatinine), and that's not including the normal 10% margin of error. None of the above actually reflects a change in real kidney function, they just change the number. On top of it, actual kidney function can indeed vary from one test to another, depending on how much active inflammation there is. Your neph is right though, in that most of the time, the trend is up. That's mainly because the tests are usually far enough apart to reflect the loss of kidney function overall. But if tested more frequently, it's easy to pick up some of that variability. So maybe you're not all that interesting During my last couple of years before dialysis, I varied a number of times between as high as over 400 umol/L down to 300 umol/L. But of course, whereas before my serum creatinine was checked maybe once or twice a year, by then, it was done much more frequently. Pierre Interesting > I saw my nephrologist yesterday, my creatinine has dropped Things > are looking better for now anyway. I have achieved unique status in > his experience, he's never seen someone whose creatinine does what > mine does, apparently a steady rise is the norm, mine looks like a > graph from the stock exchange, up down all over the place. Yet again > I'm " interesting " , I hate that word! > > He is e-mailing pharmalink re nefecon, and tanox re their monoclonal > antibody treatment. Interesting point he said was that monoclonal > antibodies are very large molecules and tend to get stuck in the > kidney, his initial impression was that they would make IgAN worse! > > He said he'll pass their responses on to me... > Quote Link to comment Share on other sites More sharing options...
Guest guest Posted June 27, 2003 Report Share Posted June 27, 2003 I agree with your reasoning however I had over four years with a slight decline in serum creatinine then it jumped from 140 to 240 (UK millimoles per cubic fortnight or whatever) and is slowly declining again. I had a similar jump to 140. I don't have a nice mathematical average progression, I have spikes followed by plateaus, but yes sadly the overall trend is up. My nephrologist told me of one patient he had who was in dire straights and her creatinine went back down to normal, this disease is a real mind bender! He sees one chap, he's an identical twin, one is fine, one is very ill. > Well at least it isn't going up. > > The important thing is the overall trend. It's not that unusual for serum > creatinine to vary, since it can be affected by hydration, exercise, the > amount of protein eaten or not eaten, nutritional status blood pressure > medications, the lab used if not always the same and the process (there are > two major ways of doing serum creatinine), and that's not including the > normal 10% margin of error. None of the above actually reflects a change in > real kidney function, they just change the number. On top of it, actual > kidney function can indeed vary from one test to another, depending on how > much active inflammation there is. > > Your neph is right though, in that most of the time, the trend is up. That's > mainly because the tests are usually far enough apart to reflect the loss of > kidney function overall. But if tested more frequently, it's easy to pick up > some of that variability. So maybe you're not all that interesting > > During my last couple of years before dialysis, I varied a number of times > between as high as over 400 umol/L down to 300 umol/L. But of course, > whereas before my serum creatinine was checked maybe once or twice a year, > by then, it was done much more frequently. > > Pierre > > Interesting > > > > I saw my nephrologist yesterday, my creatinine has dropped Things > > are looking better for now anyway. I have achieved unique status in > > his experience, he's never seen someone whose creatinine does what > > mine does, apparently a steady rise is the norm, mine looks like a > > graph from the stock exchange, up down all over the place. Yet again > > I'm " interesting " , I hate that word! > > > > He is e-mailing pharmalink re nefecon, and tanox re their monoclonal > > antibody treatment. Interesting point he said was that monoclonal > > antibodies are very large molecules and tend to get stuck in the > > kidney, his initial impression was that they would make IgAN worse! > > > > He said he'll pass their responses on to me... > > Quote Link to comment Share on other sites More sharing options...
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