Guest guest Posted June 21, 2003 Report Share Posted June 21, 2003 In a message dated 6/21/2003 2:57:56 PM Central Daylight Time, rotghi@... writes: > Oh, does anyone know is Asprin is also not allowed for people with > nephropathy? I would think it would not be allowed. You're right - I've only had one doc tell me it's OK in a limited sense. The only time I've ever taken it was when I was on dialysis, as an anticoagulant. After transplant, I haven't been allowed to take it at any time for any reason. Robin s http://www.bloggingnetwork.com/Blogs/Affil/?587 Quote Link to comment Share on other sites More sharing options...
Guest guest Posted June 21, 2003 Report Share Posted June 21, 2003 I was told aspirin is especially harmful when it is combined with acetaminophen . You find this mainly in the powder form of pain relievers. Quote Link to comment Share on other sites More sharing options...
Guest guest Posted June 21, 2003 Report Share Posted June 21, 2003 > Dear , > > That's interesting. I didn't know Clinoril was safer. I suppose the new Celebrex, Vioxx, Mobic bunch are safer than NSAIDs but nobody wants to take a chance and prescribe them to people with less than perfect kidneys. > > Oh, does anyone know is Asprin is also not allowed for people with nephropathy? I would think it would not be allowed. Also there is a medication called Plavix that thins the blood but I don't think it does anything to prostaglandins which is what the NSAIDS do. > > Rotghi Thanks Rotghi, Here is some info on it. Of course, one's neph should be involved in any decision about prescribing it. Sulindac and its sulfone metabolite undergo extensive enterohepatic circulation relative to the sulfidemetabolite in animals. Studies in man have also demonstrated that recirculation of the parent drug,sulindac, and its sulfone metabolite, is more extensive than that of the active sulfide metabolite. The activesulfide metabolite accounts for less than six percent of the total intestinal exposure to sulindac and itsmetabolites.The primary route of excretion in man is via the urine as both sulindac and its sulfone metabolite (freeand glucuronide conjugates). Approximately 50% of the administered dose is excreted in the urine, withthe conjugated sulfone metabolite accounting for the major portion. Less than 1% of the administereddose of sulindac appears in the urine as the sulfide metabolite. Approximately 25% is found in the feces,primarily as the sulfone and sulfide metabolites.The bioavailability of sulindac, as assessed by urinary excretion, was not changed by concomitantadministration of an antacid containing magnesium hydroxide 200 mg and aluminum hydroxide 225 mgper 5 mL. Because CLINORIL is excreted in the urine primarily as biologically inactive forms, it may possiblyaffect renal function to a lesser extent than other non-steroidal anti-inflammatory drugs, however, renaladverse experiences have been reported with CLINORIL (see ADVERSE REACTIONS). In a study ofpatients with chronic glomerular disease treated with therapeutic doses of CLINORIL, no effect wasdemonstrated on renal blood flow, glomerular filtration rate, or urinary excretion of prostaglandin E2andthe primary metabolite of prostacyclin, 6-keto-PGF1. However, in other studies in healthy volunteers andpatients with liver disease, CLINORIL was found to blunt the renal responses to intravenous furosemide,i.e., the diuresis, natriuresis, increments in plasma renin activity and urinary excretion of prostaglandins.These observations may represent a differentiation of the effects of CLINORIL on renal functions basedon differences in pathogenesis of the renal prostaglandin dependence associated with differing dose-response relationships of different NSAIDs to the various renal functions influenced by prostaglandins. Quote Link to comment Share on other sites More sharing options...
Guest guest Posted June 21, 2003 Report Share Posted June 21, 2003 Loved those little powders to. They really worked. Quote Link to comment Share on other sites More sharing options...
Guest guest Posted June 21, 2003 Report Share Posted June 21, 2003 And in Excedrin... > I was told aspirin is especially harmful when it is combined with > acetaminophen . You find this mainly in the powder form of pain relievers. > > > > > Quote Link to comment Share on other sites More sharing options...
Guest guest Posted June 21, 2003 Report Share Posted June 21, 2003 I don't know why. Perhaps someone else has the answer. I know I have seen a few articles on it. Quote Link to comment Share on other sites More sharing options...
Guest guest Posted June 21, 2003 Report Share Posted June 21, 2003 Thanks ! Rotghi > > > Date: 2003/06/21 Sat PM 04:57:39 EDT > To: iga-nephropathy > Subject: Re: NSAIDS, Asprin > > Quote Link to comment Share on other sites More sharing options...
Guest guest Posted June 21, 2003 Report Share Posted June 21, 2003 Thanks Robin! Rotghi > > From: Snoop81485@... > Date: 2003/06/21 Sat PM 05:11:07 EDT > To: iga-nephropathy > Subject: Re: NSAIDS, Asprin > > Quote Link to comment Share on other sites More sharing options...
Guest guest Posted June 21, 2003 Report Share Posted June 21, 2003 I wonder why it's worse with acetominophen? Is acetominophen ok on its own? Rotghi > > From: catdial@... > Date: 2003/06/21 Sat PM 08:28:20 EDT > To: iga-nephropathy > Subject: Re: NSAIDS, Asprin > > Quote Link to comment Share on other sites More sharing options...
Guest guest Posted June 21, 2003 Report Share Posted June 21, 2003 hmmmm..... maybe tell that nurse to go take a powder ???? Ooops, no, I did not say that. Cy Re: NSAIDS, Asprin Loved those little powders to. They really worked. Quote Link to comment Share on other sites More sharing options...
Guest guest Posted June 22, 2003 Report Share Posted June 22, 2003 I have seen articles as well . Another thing mentioned were things like tylonol #3 (with codeine). > I don't know why. Perhaps someone else has the answer. I know I have seen a > few articles on it. > > > > > Quote Link to comment Share on other sites More sharing options...
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