Re: today interview on fibroids

[Guest guest]

I thought she said premature menopause happens in 2 1/2 to 15 percent of

cases. At the time, I thought it was a bizarre range of numbers. Maybe I

misheard.

I would have gone ahead and done it at a 15% chance. My IR told me 5% and

that pretty much agreed with the research I had done.

Re: today interview on fibroids

> Carla wrote: " .... For instance, she told the national TV audience that

> premature

> menopause with UAE is occurring at a rate as high as 15% (???? did she

> really do this????) -- you won't find that on the story on the website

> (and it isn't supported in the literature either). "

>

[Guest guest]

Carla wrote: " .... For instance, she told the national TV audience that

premature

menopause with UAE is occurring at a rate as high as 15% (???? did she

really do this????) -- you won't find that on the story on the website

(and it isn't supported in the literature either). "

I didn't look up the Reichman interview. I have read the excerpts and

comments in messages to this discussion group and to the Yahoo embo group.

From those it is clear to me that there is a lot of misinformation given by

Dr Reichman

But there is some basis for her figure of up to 15%. It depends on whether

you consider " premature menopause " as menopause occurring before a certain

age - I think the standard dividing line is 40 - or whether you consider any

menopause brought on by a medical procedure to be premature. (I had UAE at

age 49+, no sign of menopause, and I would have been disappointed if it had

started because of the procedure. But so far I am still menstruating

normally a year later)

Spies JB, Roth AR, Gonsalves SM, -Skrzyniarz KM., " Ovarian function

after uterine artery embolization for leiomyomata: assessment with use of

serum follicle stimulating hormone assay " . : J Vasc Interv Radiol 2001

Apr;12(4):437-42

Interventional Radiology Section, Department of Radiology of town

University Hospital, Washington, DC

abstract from Entrez Med (see JVIR site for full article):

" PURPOSE: To determine if uterine artery embolization (UAE) for leiomyomata

causes a change in ovarian function as measured by serial basal follicle

stimulating hormone (FSH) assay. MATERIALS AND METHODS: Sixty-three patients

undergoing UAE for symptomatic leiomyomata had blood samples obtained on day

3 of a menstrual cycle before UAE and on day 3 during menstrual cycles 3 and

6 months after treatment. Analysis of variance was used to detect

differences in FSH levels among age groups at each interval. Repeated

measures analysis of variance was used to determine if individual mean

change occurred for the group as a whole and for each age group. Onset of

new menopausal symptoms was compared between groups with use of the chi(2)

test. RESULTS: There was no significant change in basal FSH levels for the

group as a whole (P =.16), but there was a statistically significant

difference when age groups were compared (P =.03). Individual change of >2

SD from baseline mean FSH level occurred at 6 months in seven patients, all

45-50 years of age. Four of these patients (15% of patients over age 44) had

FSH levels increase to more than 20 IU/L. chi(2) analysis did not reveal any

difference among the groups studied in the onset of menopausal symptoms.

CONCLUSIONS: Most patients had no change in ovarian function as measured by

basal FSH after UAE. For patients aged 45 or older, there is approximately a

15% chance of an increase in basal FSH into the perimenopausal range. "

my notes:

1. this is a measure for being perimenopausal, not necessarily a measure of

cessation of periods (but the FSH testing is done to give a more precise

before/after picture of what is happening to women's ovaries in UAE than

from recording whether or not women have periods)

2. it is hard to know how often UAE is the precipitating cause of menopausal

symptoms/amenorhea in women over 44 or whether it is coincidental because

these symptoms can come on very quickly in this age group. The incidence of

ovarian problems after UAE is much smaller in younger women and often the

problems are temporary.

3. the study sample is very small

[Guest guest]

Carla,

The IR I saw told me that there is ovarian failure in

2-20% of all UAE's. I was surprised by the 20%. Do

you have any info on literature that may have better

information? Yhanks.

Sue

--- Carla Dionne wrote:

> I tried to piece together the " true " transcript of

> Judith Reichman's

> interview on the Today show and was surprised at how

> much the statistics

> she spoke on TV did not match the current content on

> the ABC News

> website. For instance, she told the national TV

> audience that premature

> menopause with UAE is occurring at a rate as high as

> 15% (???? did she

> really do this????) -- you won't find that on the

> story on the website

> (and it isn't supported in the literature either).

>

> ----------------------------------------

>

>

__________________________________________________

[Guest guest]

Carla,

The IR I saw told me that there is ovarian failure in

2-20% of all UAE's. I was surprised by the 20%. Do

you have any info on literature that may have better

information? Yhanks.

Sue

--- Carla Dionne wrote:

> I tried to piece together the " true " transcript of

> Judith Reichman's

> interview on the Today show and was surprised at how

> much the statistics

> she spoke on TV did not match the current content on

> the ABC News

> website. For instance, she told the national TV

> audience that premature

> menopause with UAE is occurring at a rate as high as

> 15% (???? did she

> really do this????) -- you won't find that on the

> story on the website

> (and it isn't supported in the literature either).

>

> ----------------------------------------

>

>

__________________________________________________

[Guest guest]

Carla,

The IR I saw told me that there is ovarian failure in

2-20% of all UAE's. I was surprised by the 20%. Do

you have any info on literature that may have better

information? Yhanks.

Sue

--- Carla Dionne wrote:

> I tried to piece together the " true " transcript of

> Judith Reichman's

> interview on the Today show and was surprised at how

> much the statistics

> she spoke on TV did not match the current content on

> the ABC News

> website. For instance, she told the national TV

> audience that premature

> menopause with UAE is occurring at a rate as high as

> 15% (???? did she

> really do this????) -- you won't find that on the

> story on the website

> (and it isn't supported in the literature either).

>

> ----------------------------------------

>

>

__________________________________________________

[Guest guest]

Sue Winner wrote:

> Carla,

>

> The IR I saw told me that there is ovarian failure in

> 2-20% of all UAE's. I was surprised by the 20%. Do

> you have any info on literature that may have better

> information? Yhanks.

Sue,

I just finished a thorough review of the UAE literature on this issue (and how

it relates to fertility

retention/loss) for a paper I was writing and never came across numbers that

were showing absolute

ovarian failure in 15-20% range. I would, however, not be surprised if it does

actually hit the ~10%

range -- as that would more closely resemble some concerns I have over the

numbers of women with

shared blood flow between the uterine artery and ovarian artery who proceed with

UAE. Furthermore, in

women who are long-term OC users (5 years or more), I wouldn't be surprised in

the least if they too

were hit with premature menopause -- but would guestimate that that would have

occurred anyway but may

end up getting blamed on UAE.

Who was the IR who told you 2-20%?

Carla

[Guest guest]

Sue Winner wrote:

> Carla,

>

> The IR I saw told me that there is ovarian failure in

> 2-20% of all UAE's. I was surprised by the 20%. Do

> you have any info on literature that may have better

> information? Yhanks.

Sue,

I just finished a thorough review of the UAE literature on this issue (and how

it relates to fertility

retention/loss) for a paper I was writing and never came across numbers that

were showing absolute

ovarian failure in 15-20% range. I would, however, not be surprised if it does

actually hit the ~10%

range -- as that would more closely resemble some concerns I have over the

numbers of women with

shared blood flow between the uterine artery and ovarian artery who proceed with

UAE. Furthermore, in

women who are long-term OC users (5 years or more), I wouldn't be surprised in

the least if they too

were hit with premature menopause -- but would guestimate that that would have

occurred anyway but may

end up getting blamed on UAE.

Who was the IR who told you 2-20%?

Carla

[Guest guest]

Sue Winner wrote:

> Carla,

>

> The IR I saw told me that there is ovarian failure in

> 2-20% of all UAE's. I was surprised by the 20%. Do

> you have any info on literature that may have better

> information? Yhanks.

Sue,

I just finished a thorough review of the UAE literature on this issue (and how

it relates to fertility

retention/loss) for a paper I was writing and never came across numbers that

were showing absolute

ovarian failure in 15-20% range. I would, however, not be surprised if it does

actually hit the ~10%

range -- as that would more closely resemble some concerns I have over the

numbers of women with

shared blood flow between the uterine artery and ovarian artery who proceed with

UAE. Furthermore, in

women who are long-term OC users (5 years or more), I wouldn't be surprised in

the least if they too

were hit with premature menopause -- but would guestimate that that would have

occurred anyway but may

end up getting blamed on UAE.

Who was the IR who told you 2-20%?

Carla

[Guest guest]

Link with University of California

Medical Center, Sacramento, CA.

--- Carla Dionne wrote:

> Sue Winner wrote:

>

> > Carla,

> >

> > The IR I saw told me that there is ovarian failure

> in

> > 2-20% of all UAE's. I was surprised by the 20%.

> Do

> > you have any info on literature that may have

> better

> > information? Yhanks.

>

> Sue,

>

> I just finished a thorough review of the UAE

> literature on this issue (and how it relates to

> fertility

> retention/loss) for a paper I was writing and never

> came across numbers that were showing absolute

> ovarian failure in 15-20% range. I would, however,

> not be surprised if it does actually hit the ~10%

> range -- as that would more closely resemble some

> concerns I have over the numbers of women with

> shared blood flow between the uterine artery and

> ovarian artery who proceed with UAE. Furthermore,

> in

> women who are long-term OC users (5 years or more),

> I wouldn't be surprised in the least if they too

> were hit with premature menopause -- but would

> guestimate that that would have occurred anyway but

> may

> end up getting blamed on UAE.

>

> Who was the IR who told you 2-20%?

>

> Carla

>

>

>

>

> [Non-text portions of this message have been

> removed]

>

>

__________________________________________________

[Guest guest]

Link with University of California

Medical Center, Sacramento, CA.

--- Carla Dionne wrote:

> Sue Winner wrote:

>

> > Carla,

> >

> > The IR I saw told me that there is ovarian failure

> in

> > 2-20% of all UAE's. I was surprised by the 20%.

> Do

> > you have any info on literature that may have

> better

> > information? Yhanks.

>

> Sue,

>

> I just finished a thorough review of the UAE

> literature on this issue (and how it relates to

> fertility

> retention/loss) for a paper I was writing and never

> came across numbers that were showing absolute

> ovarian failure in 15-20% range. I would, however,

> not be surprised if it does actually hit the ~10%

> range -- as that would more closely resemble some

> concerns I have over the numbers of women with

> shared blood flow between the uterine artery and

> ovarian artery who proceed with UAE. Furthermore,

> in

> women who are long-term OC users (5 years or more),

> I wouldn't be surprised in the least if they too

> were hit with premature menopause -- but would

> guestimate that that would have occurred anyway but

> may

> end up getting blamed on UAE.

>

> Who was the IR who told you 2-20%?

>

> Carla

>

>

>

>

> [Non-text portions of this message have been

> removed]

>

>

__________________________________________________