Guest guest Posted October 6, 2000 Report Share Posted October 6, 2000 Yes I agree with you Pete. From what I have understood from my readings and my Geneticists your words are so. ine Re: Help quickly needed > In a message dated 10/6/00 2:33:17 PM Eastern Daylight Time, mcdrew@... > writes: > > << you have a child and that DEFI NITELY does not have > NF2, then HIS children will NOT get NF2 >> > > > Unless his/her children are spontaneous cases.. > But what Marie's point is (and this what I've been told) NF2 doesn't skip a > generation.. If you don't give it to your siblings, you don't have any effect > on their kids, they have just as much of a chance of getting it spontaneously > as everyone else > > Pete > > > > Quote Link to comment Share on other sites More sharing options...
Guest guest Posted October 6, 2000 Report Share Posted October 6, 2000 The genetics dictate 50/50, but the 99% of half your children stat probably comes from natural history studies. This is like 249/251, or something like that. Not a significant (statistically speaking) difference. > I have read that if you have NF2 you have a 99% chance of passing it on to > half your children. > > Anita Quote Link to comment Share on other sites More sharing options...
Guest guest Posted October 6, 2000 Report Share Posted October 6, 2000 If you have NF1, you can't GIVE your child NF2, and vice versa. However, there is no reason why a person with NF2 can't be mutant for NF1 and vice versa. These people DO exist. In my travels through the NF community, I have met them. , who got a 9 in genetics. I've heard doctors say if > you have one type of NF that is what is inherited. > Just repeating what I've heard the docs say. > K. Quote Link to comment Share on other sites More sharing options...
Guest guest Posted October 7, 2000 Report Share Posted October 7, 2000 , Don't worry. I'm not offended that you disagreed with me. Through the years I've come to realize doctors are NOT gods. They are human just as we are. I've been dealing with NF2 and doctors since my NF diagnosis in October 1977. With NF2 there is still SO much to be learned about it that doctors are often at a loss. I often know MORE about NF2 than most of the drs. who are treating me. Actually, I have a very active participation in my health care. I read up as much as I can. Many times my primary dr. will go with what I want to do. He and I talk then decide together what to do together. I'm NOT a " wooden " patient. () K.. Re: Help quickly needed > > Pete, > From what I've heard doctors say through the years if you have NF1 and > your child inherits, it WILL inherit NF1. Coversely, if you have NF2 and the > child inherist it will be NF2 that is inherited. I've heard doctors say if > you have one type of NF that is what is inherited. > Just repeating what I've heard the docs say. > K. > > > > > Quote Link to comment Share on other sites More sharing options...
Guest guest Posted October 7, 2000 Report Share Posted October 7, 2000 I Live in a Province of Wheat farmer,s.Canada. Re: Help quickly needed > > > > In a message dated 10/6/00 3:40:36 PM Eastern Daylight Time, > > amazon40@... writes: > > > > << Hi Crew,Just thought i would pass on what we were told about Nf2.My son > has > > NF2,my father has NF1.I have absolutely nothing.I was also told it > doesn't > > skip a generation.Figure that one out.My son was told it is a 50% chance > of > > his children having this lovely disease.It's bad when a 20 yr old man is > > considering a vasectomy. Pam Lakeman >> > > > > Most likely he was a spontaneous mutation and there wasn't any connection > > between your father and him.. I think (I'm guessing here admittedly) if > you > > have NF1 you can't give your kids NF2 or vice versa, I think it stays the > > same. I could be wrong tho > > > > Pete > > > > > > > > > > Quote Link to comment Share on other sites More sharing options...
Guest guest Posted October 7, 2000 Report Share Posted October 7, 2000 I Live in a Province of Wheat farmer,s.Canada. Re: Help quickly needed > > > > In a message dated 10/6/00 3:40:36 PM Eastern Daylight Time, > > amazon40@... writes: > > > > << Hi Crew,Just thought i would pass on what we were told about Nf2.My son > has > > NF2,my father has NF1.I have absolutely nothing.I was also told it > doesn't > > skip a generation.Figure that one out.My son was told it is a 50% chance > of > > his children having this lovely disease.It's bad when a 20 yr old man is > > considering a vasectomy. Pam Lakeman >> > > > > Most likely he was a spontaneous mutation and there wasn't any connection > > between your father and him.. I think (I'm guessing here admittedly) if > you > > have NF1 you can't give your kids NF2 or vice versa, I think it stays the > > same. I could be wrong tho > > > > Pete > > > > > > > > > > Quote Link to comment Share on other sites More sharing options...
Guest guest Posted October 7, 2000 Report Share Posted October 7, 2000 I Live in a Province of Wheat farmer,s.Canada. Re: Help quickly needed > > > > In a message dated 10/6/00 3:40:36 PM Eastern Daylight Time, > > amazon40@... writes: > > > > << Hi Crew,Just thought i would pass on what we were told about Nf2.My son > has > > NF2,my father has NF1.I have absolutely nothing.I was also told it > doesn't > > skip a generation.Figure that one out.My son was told it is a 50% chance > of > > his children having this lovely disease.It's bad when a 20 yr old man is > > considering a vasectomy. Pam Lakeman >> > > > > Most likely he was a spontaneous mutation and there wasn't any connection > > between your father and him.. I think (I'm guessing here admittedly) if > you > > have NF1 you can't give your kids NF2 or vice versa, I think it stays the > > same. I could be wrong tho > > > > Pete > > > > > > > > > > Quote Link to comment Share on other sites More sharing options...
Guest guest Posted October 8, 2000 Report Share Posted October 8, 2000 hi Crew - my understanding is that EACH child of a person w/ NF2 has a 50/50 chance of having NF2. they could all have it or not have it and only pass it on if they do have it. obviously the more kids involved, there will be some that do and some that don't. the next generation - only the people that have NF2 can pass it on. but EACH of their children again face the 50/50 odds. sorry the odds don't go down. hugs, LynnBK > Subject: FW: Help quickly needed Carol, That is interesting. I never thought about that but it sounds correct to me. Lets do a simple example. Lets say a person with NF2 has 2 kids. The odds are that 1 will have NF2 and the other will not. Now lets say each child has 2 kids of their own. The child with out NF2 cannot pass it on so the 2 kids will not have NF2 (they actually can as a mutation but that is unlikely). The odds are 1 kid from the NF2 child will have NF2 and the other will not. So (if you are still with me), we have 4 grandchildren of the original NF2 person. Only 1 grandchild has NF2 and the other 3 do not. That sounds like a 25% chance to me. Hope you followed the example. I'm pretty sure this will always be the case (you can't really prove much with just one example). This was a interesting tidbit. Thanks for passing it along. ---------- From: Carol Winarski Sent: Friday, October 06, 2000 1:58 PM To: NF2_Crewegroups Subject: Re: Help quickly needed I was told that my kids have a 50% chance of having it and my grandchildren 25%. Carol schweickerta@... wrote: > I have read that if you have NF2 you have a 99% chance of passing it on to > half your children. > > Anita Quote Link to comment Share on other sites More sharing options...
Guest guest Posted October 8, 2000 Report Share Posted October 8, 2000 Crew, >Lets do a simple example. Lets say a person with NF2 has 2 kids. The odds are that 1 >will have NF2 and the other will not You have to remember that the 50/50 odds of your child having NF2 applies to EACH child, every time you conceive. It does not apply to all your children, ie, it does not mean that half your children will have NF2. It means that each child you have has a 50/50 chance of inheriting NF2. If you want to examine the odds of, say, 3 of your 5 children having NF2, then you have to do some probability calculations. BTW, the Probability of exactly 3 of your 5 children having NF2 is 10/32. (2^5=32 and 5 choose 3 is 10) __ " What we know is not so important as What we do not know " Http://www.westerncanada.com/~jchartra Quote Link to comment Share on other sites More sharing options...
Guest guest Posted October 8, 2000 Report Share Posted October 8, 2000 Crew, >Lets do a simple example. Lets say a person with NF2 has 2 kids. The odds are that 1 >will have NF2 and the other will not You have to remember that the 50/50 odds of your child having NF2 applies to EACH child, every time you conceive. It does not apply to all your children, ie, it does not mean that half your children will have NF2. It means that each child you have has a 50/50 chance of inheriting NF2. If you want to examine the odds of, say, 3 of your 5 children having NF2, then you have to do some probability calculations. BTW, the Probability of exactly 3 of your 5 children having NF2 is 10/32. (2^5=32 and 5 choose 3 is 10) __ " What we know is not so important as What we do not know " Http://www.westerncanada.com/~jchartra Quote Link to comment Share on other sites More sharing options...
Guest guest Posted October 9, 2000 Report Share Posted October 9, 2000 Lynn/, What I assumed in my post was that the 50/50 odds will work out EXACTLY when having the kids. I know this does not happen in reality. But for the sake of the example, you have to assume something. I understand that if you flip a coin 2 times you may get 2 heads or 2 tails. However, the most probable outcome BEFORE you start flipping is 1 head and 1 tail. (BTW, there is a 50% chance you will get 1 head and 1 tail, a 25% chance you will get 2 heads and a 25% chance of getting 2 tails - this can be applied to NF2 and kids). Perhaps you are thinking that if you flip and get a head the chances of getting another head on the next flip are still 50/50. This is true of course. This is different than my example where I am taking the odds BEFORE the flipping starts. The OVERALL odds that a grandchildren will have NF2 are 25%. This is because a child may not have NF2 and therefore the odds of that child having children with NF2 are essentially 0. However, if you look ONLY at the grandchild with NF2, the odds are still 50%. I hope this clarifies the issue. I think perhaps we are saying the same thing but looking at this from different angles. ---------- From: lynnbk@... Sent: Sunday, October 08, 2000 2:19 PM To: NF2_Crewegroups Subject: re: help quickly needed hi Crew - my understanding is that EACH child of a person w/ NF2 has a 50/50 chance of having NF2. they could all have it or not have it and only pass it on if they do have it. obviously the more kids involved, there will be some that do and some that don't. the next generation - only the people that have NF2 can pass it on. but EACH of their children again face the 50/50 odds. sorry the odds don't go down. hugs, LynnBK > Subject: FW: Help quickly needed Carol, That is interesting. I never thought about that but it sounds correct to me. Lets do a simple example. Lets say a person with NF2 has 2 kids. The odds are that 1 will have NF2 and the other will not. Now lets say each child has 2 kids of their own. The child with out NF2 cannot pass it on so the 2 kids will not have NF2 (they actually can as a mutation but that is unlikely). The odds are 1 kid from the NF2 child will have NF2 and the other will not. So (if you are still with me), we have 4 grandchildren of the original NF2 person. Only 1 grandchild has NF2 and the other 3 do not. That sounds like a 25% chance to me. Hope you followed the example. I'm pretty sure this will always be the case (you can't really prove much with just one example). This was a interesting tidbit. Thanks for passing it along. ---------- From: Carol Winarski Sent: Friday, October 06, 2000 1:58 PM To: NF2_Crewegroups Subject: Re: Help quickly needed I was told that my kids have a 50% chance of having it and my grandchildren 25%. Carol schweickerta@... wrote: > I have read that if you have NF2 you have a 99% chance of passing it on to > half your children. > > Anita Quote Link to comment Share on other sites More sharing options...
Guest guest Posted October 9, 2000 Report Share Posted October 9, 2000 Lynn/, What I assumed in my post was that the 50/50 odds will work out EXACTLY when having the kids. I know this does not happen in reality. But for the sake of the example, you have to assume something. I understand that if you flip a coin 2 times you may get 2 heads or 2 tails. However, the most probable outcome BEFORE you start flipping is 1 head and 1 tail. (BTW, there is a 50% chance you will get 1 head and 1 tail, a 25% chance you will get 2 heads and a 25% chance of getting 2 tails - this can be applied to NF2 and kids). Perhaps you are thinking that if you flip and get a head the chances of getting another head on the next flip are still 50/50. This is true of course. This is different than my example where I am taking the odds BEFORE the flipping starts. The OVERALL odds that a grandchildren will have NF2 are 25%. This is because a child may not have NF2 and therefore the odds of that child having children with NF2 are essentially 0. However, if you look ONLY at the grandchild with NF2, the odds are still 50%. I hope this clarifies the issue. I think perhaps we are saying the same thing but looking at this from different angles. ---------- From: lynnbk@... Sent: Sunday, October 08, 2000 2:19 PM To: NF2_Crewegroups Subject: re: help quickly needed hi Crew - my understanding is that EACH child of a person w/ NF2 has a 50/50 chance of having NF2. they could all have it or not have it and only pass it on if they do have it. obviously the more kids involved, there will be some that do and some that don't. the next generation - only the people that have NF2 can pass it on. but EACH of their children again face the 50/50 odds. sorry the odds don't go down. hugs, LynnBK > Subject: FW: Help quickly needed Carol, That is interesting. I never thought about that but it sounds correct to me. Lets do a simple example. Lets say a person with NF2 has 2 kids. The odds are that 1 will have NF2 and the other will not. Now lets say each child has 2 kids of their own. The child with out NF2 cannot pass it on so the 2 kids will not have NF2 (they actually can as a mutation but that is unlikely). The odds are 1 kid from the NF2 child will have NF2 and the other will not. So (if you are still with me), we have 4 grandchildren of the original NF2 person. Only 1 grandchild has NF2 and the other 3 do not. That sounds like a 25% chance to me. Hope you followed the example. I'm pretty sure this will always be the case (you can't really prove much with just one example). This was a interesting tidbit. Thanks for passing it along. ---------- From: Carol Winarski Sent: Friday, October 06, 2000 1:58 PM To: NF2_Crewegroups Subject: Re: Help quickly needed I was told that my kids have a 50% chance of having it and my grandchildren 25%. Carol schweickerta@... wrote: > I have read that if you have NF2 you have a 99% chance of passing it on to > half your children. > > Anita Quote Link to comment Share on other sites More sharing options...
Guest guest Posted October 9, 2000 Report Share Posted October 9, 2000 Lynn/, What I assumed in my post was that the 50/50 odds will work out EXACTLY when having the kids. I know this does not happen in reality. But for the sake of the example, you have to assume something. I understand that if you flip a coin 2 times you may get 2 heads or 2 tails. However, the most probable outcome BEFORE you start flipping is 1 head and 1 tail. (BTW, there is a 50% chance you will get 1 head and 1 tail, a 25% chance you will get 2 heads and a 25% chance of getting 2 tails - this can be applied to NF2 and kids). Perhaps you are thinking that if you flip and get a head the chances of getting another head on the next flip are still 50/50. This is true of course. This is different than my example where I am taking the odds BEFORE the flipping starts. The OVERALL odds that a grandchildren will have NF2 are 25%. This is because a child may not have NF2 and therefore the odds of that child having children with NF2 are essentially 0. However, if you look ONLY at the grandchild with NF2, the odds are still 50%. I hope this clarifies the issue. I think perhaps we are saying the same thing but looking at this from different angles. ---------- From: lynnbk@... Sent: Sunday, October 08, 2000 2:19 PM To: NF2_Crewegroups Subject: re: help quickly needed hi Crew - my understanding is that EACH child of a person w/ NF2 has a 50/50 chance of having NF2. they could all have it or not have it and only pass it on if they do have it. obviously the more kids involved, there will be some that do and some that don't. the next generation - only the people that have NF2 can pass it on. but EACH of their children again face the 50/50 odds. sorry the odds don't go down. hugs, LynnBK > Subject: FW: Help quickly needed Carol, That is interesting. I never thought about that but it sounds correct to me. Lets do a simple example. Lets say a person with NF2 has 2 kids. The odds are that 1 will have NF2 and the other will not. Now lets say each child has 2 kids of their own. The child with out NF2 cannot pass it on so the 2 kids will not have NF2 (they actually can as a mutation but that is unlikely). The odds are 1 kid from the NF2 child will have NF2 and the other will not. So (if you are still with me), we have 4 grandchildren of the original NF2 person. Only 1 grandchild has NF2 and the other 3 do not. That sounds like a 25% chance to me. Hope you followed the example. I'm pretty sure this will always be the case (you can't really prove much with just one example). This was a interesting tidbit. Thanks for passing it along. ---------- From: Carol Winarski Sent: Friday, October 06, 2000 1:58 PM To: NF2_Crewegroups Subject: Re: Help quickly needed I was told that my kids have a 50% chance of having it and my grandchildren 25%. Carol schweickerta@... wrote: > I have read that if you have NF2 you have a 99% chance of passing it on to > half your children. > > Anita Quote Link to comment Share on other sites More sharing options...
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