Guest guest Posted October 14, 2000 Report Share Posted October 14, 2000 I thought that NF2 resulted from a mutation, but it's actually results from a missing gene?? Which chromosome is the suppressor gene found in? Is it still the same gene in which the believed mutation occurs?? Or is not having the suppressor gene considered the mutation? Greg Barbara,I can see that NF2 is a chronic problem. What I have been told is that we are missing a tumor supressor gene. Tumors grow naturally in everyone's body but others have the tumor supessor gene to keep the tumors in check. So.... all we need is the tumor supressor gene. Is this not so?? Quote Link to comment Share on other sites More sharing options...
Guest guest Posted October 14, 2000 Report Share Posted October 14, 2000 I thought that NF2 resulted from a mutation, but it's actually results from a missing gene?? Which chromosome is the suppressor gene found in? Is it still the same gene in which the believed mutation occurs?? Or is not having the suppressor gene considered the mutation? Greg Barbara,I can see that NF2 is a chronic problem. What I have been told is that we are missing a tumor supressor gene. Tumors grow naturally in everyone's body but others have the tumor supessor gene to keep the tumors in check. So.... all we need is the tumor supressor gene. Is this not so?? Quote Link to comment Share on other sites More sharing options...
Guest guest Posted October 14, 2000 Report Share Posted October 14, 2000 I thought that NF2 resulted from a mutation, but it's actually results from a missing gene?? Which chromosome is the suppressor gene found in? Is it still the same gene in which the believed mutation occurs?? Or is not having the suppressor gene considered the mutation? Greg Barbara,I can see that NF2 is a chronic problem. What I have been told is that we are missing a tumor supressor gene. Tumors grow naturally in everyone's body but others have the tumor supessor gene to keep the tumors in check. So.... all we need is the tumor supressor gene. Is this not so?? Quote Link to comment Share on other sites More sharing options...
Guest guest Posted October 14, 2000 Report Share Posted October 14, 2000 on 15/10/00 9:15 AM, bfrank4fr@... at bfrank4fr@... wrote: > Dear , > I don't understand genetics and gene therapy well, but they do have the gene > product--Merlin, but don't yet know how to get it delivered throughout the > nervous system. If I had to guess, perhaps the first step would be trying to > get it into a particular tumor and try to stop the growth. > > Barbara F > > Can't they just inject,either in vivo (in the subcutaneous fat) or directly to the cells of most concern, genes that have active merlin production, which then go on to multiply and hopefully correct the problem. Rosemary Quote Link to comment Share on other sites More sharing options...
Guest guest Posted October 15, 2000 Report Share Posted October 15, 2000 Greg, A mutation in the DNA leads to either a deletion of the section of the chromosome that codes for a protein (this section is called a gene), or a change in the code which leads to a defective protein. In the case of NF2, the gene product is believed to be merlin, and in people with NF2 this gene has been altered or deleted, thus leading to no production of merlin. Genes are like countries. Chromosomes are like continents -- they have finite boundaries, that contain countries. DNA is the stuff that chromosomes are made of. > Date: Sat, 14 Oct 2000 18:39:23 -0400 > > Subject: Re: Gene therapy > > > I thought that NF2 resulted from a mutation, but it's actually results from a > missing gene?? Which chromosome is the suppressor gene found in? Is it still > the same gene in which the believed mutation occurs?? Or is not having the > suppressor gene considered the mutation? > > Greg Quote Link to comment Share on other sites More sharing options...
Guest guest Posted October 15, 2000 Report Share Posted October 15, 2000 Greg, A mutation in the DNA leads to either a deletion of the section of the chromosome that codes for a protein (this section is called a gene), or a change in the code which leads to a defective protein. In the case of NF2, the gene product is believed to be merlin, and in people with NF2 this gene has been altered or deleted, thus leading to no production of merlin. Genes are like countries. Chromosomes are like continents -- they have finite boundaries, that contain countries. DNA is the stuff that chromosomes are made of. > Date: Sat, 14 Oct 2000 18:39:23 -0400 > > Subject: Re: Gene therapy > > > I thought that NF2 resulted from a mutation, but it's actually results from a > missing gene?? Which chromosome is the suppressor gene found in? Is it still > the same gene in which the believed mutation occurs?? Or is not having the > suppressor gene considered the mutation? > > Greg Quote Link to comment Share on other sites More sharing options...
Guest guest Posted October 15, 2000 Report Share Posted October 15, 2000 Greg, A mutation in the DNA leads to either a deletion of the section of the chromosome that codes for a protein (this section is called a gene), or a change in the code which leads to a defective protein. In the case of NF2, the gene product is believed to be merlin, and in people with NF2 this gene has been altered or deleted, thus leading to no production of merlin. Genes are like countries. Chromosomes are like continents -- they have finite boundaries, that contain countries. DNA is the stuff that chromosomes are made of. > Date: Sat, 14 Oct 2000 18:39:23 -0400 > > Subject: Re: Gene therapy > > > I thought that NF2 resulted from a mutation, but it's actually results from a > missing gene?? Which chromosome is the suppressor gene found in? Is it still > the same gene in which the believed mutation occurs?? Or is not having the > suppressor gene considered the mutation? > > Greg Quote Link to comment Share on other sites More sharing options...
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