Guest guest Posted September 13, 2005 Report Share Posted September 13, 2005 " But I have not seen research indicating that once one is in the " normal range " , additional lowering of one's A1C decreases the probability of diabetic complications. " The better known complications kick in at the high end of the 6 range where the curve for risk increases greatly. Heart disease and the more general cvd risk knows no lower range starting around 5 when the data runs out for research into the matter. the rate is linear with each measure of increase from within the normal range. Less researched complications such as erectile function and the neural involvement in feet and bowels etc. have already started to kick in before diagnosis and any thresholds are not known. The a1c is a proxy for glycation in all tissues of the body, not just for blood cells. It affects more long lasting cells such as connective tissue in skin and tendons for example and lead to such things as frozen shoulder. Glycation is indirectly related to rate of physical aging and diabetics are often said to be 10 years older then others at the same calendar age. If a type 2, increased rates of beta cell death and suppression of new cells is a factor. Your statement is only valid for such things as having limbs chopped off and losing sight, not heart/stroke and the other things mentioned for which there is no lower limit or they are unknown. XB IC|XC Quote Link to comment Share on other sites More sharing options...
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