Anti-acid meds increase risk of allergy

[Guest guest]

_Allergy._ (javascript:AL_get(this, 'jour', 'Allergy.') 2009 Feb 5. [Epub

ahead of print]

_Related Articles_

(http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed & DbFrom=pubmed & Cmd=Link & LinkN\

ame=pubmed_pubmed & LinkReadableName=Related%20Articles & Id

sFromResult=19210370 & ordinalpos=1 & itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_Re

sultsPanel.Pubmed_RVCitation) , _Links_

(javascript:PopUpMenu2_Set(Menu19210370)

(http://www.ncbi.nlm.nih.gov/entrez/utils/fref.fcgi?PrId=3046 & itool=Citation-def\

& uid=19210370 & db=pubmed & url=http://dx.doi.org/10.1111/j.1398-9995.2008.0193

3.x)

Aluminium per se and in the anti-acid drug sucralfate promotes sensitization

via the oral route.

_Brunner R_

(

" [Author] & itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPane

l.Pubmed_RVCitation) , _Wallmann J_

(

J " [Author] & itool=EntrezSystem2.PEntrez.

Pubmed.Pubmed_ResultsPanel.Pubmed_RVCitation) , _Szalai K_

(http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed & Cmd=Search & Term= " Szalai%20K " \

[Author] & itool=E

ntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVCitation) ,

_Karagiannis P_

(

%20P " [Author] & itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel

..Pubmed_RVCitation) , _Altmeppen H_

(

0H " [Author] & itool=EntrezSystem2.PEntrez

..Pubmed.Pubmed_ResultsPanel.Pubmed_RVCitation) , _Riemer AB_

(

" [Author] & itoo

l=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVCitation) ,

_Jensen-Jarolim E_

(

lim%20E " [Author] & itoo

l=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVCitation) ,

_Pali-Schöll I_

(

%20I " [Author] & itool=EntrezSy

stem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVCitation) .

Department of Pathophysiology, Medical University of Vienna, Vienna, Austria.

Background: Aluminium (ALUM) is used as experimental and clinical adjuvant

for parenteral vaccine formulation. It is also contained in anti-acid drugs

like sucralfate (SUC). These anti-acids have been shown to cause sensitization

to food proteins via elevation of the gastric pH. The aim of this study was

to assess the oral adjuvant properties of ALUM, alone or contained in SUC, in

a BALB/c mouse model. Methods: Mice were fed SUC plus ovalbumin (OVA) and

compared with groups where ALUM or proton pump inhibitors (PPI) were applied as

adjuvants. The humoral and cellular immune responses were assessed on

antigen-specific antibody and cytokine levels. The in vivo relevance was

investigated in skin tests. Results: The highest OVA-specific immunoglobulin G1

(IgG1)

and IgE antibody levels were found in mice fed with OVA/SUC, followed by

OVA/ALUM-treated animals, indicating a T helper 2 (Th2) shift in both groups.

Antibody levels in other groups revealed lower (OVA/PPI-group) or baseline

levels

(control groups). Positive skin tests confirmed an allergic response in

anti-acid or adjuvant-treated animals. Conclusions: Our data show for the first

time that ALUM acts as a Th2-adjuvant via the oral route. This suggests that

orally applied SUC leads to an enhanced risk for food allergy, not only by

inhibiting peptic digestion but also by acting as a Th2-adjuvant by its ALUM

content.

Jan Patenaude, RD, CLT

Consultant, Writer, Speaker

Director of Medical Nutrition

Signet Diagnostic Corporation

(Mountain Time)

Fax:

DineRight4@...

Mediator Release Testing and LEAP Diet Protocol for Irritable Bowel

Syndrome, Migraine, Fibromyalgia and more. Co-developer of Certified LEAP

Therapist

Training.

IMPORTANT - This e-mail message is intended only for the use of the

individual or entity to which it is addressed, and may contain information that

is

privileged, confidential and exempt from disclosure under applicable law. If

you have received this message in error, you are hereby notified that we do not

consent to any reading, dissemination, distribution or copying of this

e-mail message. If you have received this communication in error, please notify

the sender immediately by e-mail and telephone ( toll free) and

destroy the transmitted information.

E-mail transmission cannot be guaranteed to be secure or error-free as

information could be intercepted, corrupted, lost, destroyed, arrive late,

incomplete, or contain viruses. The sender therefore does not accept liability

for

any errors or omissions in the contents of this message, which arise as a

result of e-mail transmission.

**************A Good Credit Score is 700 or Above. See yours in just 2 easy

steps!

(http://pr.atwola.com/promoclk/100126575x1219957551x1201325337/aol?redir=http:%2\

F%2Fwww.freecreditreport.com%2Fpm%2Fdefault.aspx%3Fsc%3D668072%26hmpgID

%3D62%26bcd%3DfebemailfooterNO62)