FW: [acb-diabetics] FW: Interesting research

[Guest guest]

Fw: Interesting research

I thought this interesting and maybe you want to pass on to your group.

Donna

Interesting research

Taken from this morning's Milwaukee Journal Sentinel

Cell transplants at UW-Madison free diabetic from daily insulin

injections

By KAWANZA L. GRIFFIN

kgriffin@...

Posted: Oct. 29, 2004

Madison - Dan Quigley is eating ice cream again.

After three pancreatic islet cell transplants, the Door County man

has

become the first Wisconsin resident with Type 1 diabetes to be

declared

free of the need for insulin injections.

Quigley, 55, threw out his insulin last week.

" The first day not using it was not so much emotional, but I kept

thinking, 'What am I missing?' and walking to the refrigerator to get

a

shot, " he said.

Free from Injections

Islet cell transplantation is an experimental procedure for people with

Type 1 diabetes that is being performed at several research centers

throughout the nation, including the University of Wisconsin- Madison.

The procedure involves extraction of insulin-producing islet cells

from

donated pancreases that are then directly infused into the patient's

liver.

However, each patient needs cells from at least two donated

pancreases,

which are in short supply, said Jon Odorico, the UW surgeon who

performed

Quigley's procedures.

" There are approximately 6,000 multi-organ cadaver donors each year, "

he

said. " Less than 50 percent, on average, donate a pancreas. "

In addition, most pancreases - 1,600 - are used for transplants;

fewer

than 100 are used for islet cell extraction, Odorico said.

Embryonic stem cells, such as the ones he grows in his lab, may

someday

provide a limitless supply of the special cells that make insulin,

pancreatic islet beta cells. But for now, the cells are available

only

from donated organs.

Quigley had his first transplant in September 2002, after which he

was

able to cut his insulin use in half, he said. The second transplant

was in

June 2003, followed by his final one this past July.

He has now joined a handful of people who have been able to stop

using

insulin after treatment.

People who have Type 1 diabetes, also known as juvenile diabetes, are

unable to produce insulin, the hormone that helps convert sugar and

starch

to energy. Type 1 diabetics must take daily insulin shots as well as

follow special diet and exercise programs.

But despite treatment, many patients ultimately go blind, develop

kidney

failure or suffer other life-threatening complications.

Transplant costs high

Even with the islet cell advances, the cost to perform

transplantation can

be astronomical, said Steve Woodle, chief of the division of

transplantation at University Hospital in Cincinnati and a professor

of

surgery at the University of Cincinnati.

" It's great for Wisconsin, and it's certainly a big step for research

and

people with diabetes, " he said. " But it's not cheap. "

Woodle said that one problem is the rising cost of donor pancreases -

from

$2,500 to $20,000 - which contribute to an average cost of $200,000

to

$250,000 per treatment, he said.

As a result, the privately funded procedures at University Hospital

are

now " on hold " despite success in six patients, one of whom no longer

needed insulin injections after just one transplant. That patient is

still

off insulin two years later.

" (Cost is) a real problem, " Woodle said.

UW's islet cell transplants are part of a clinical study funded by a

pharmaceutical company and conducted by Odorico and colleague

Fernandez. Both physicians are directors of the islet cell transplant

program at UW.

The purpose of the study is to determine the effectiveness of the

drug

pioglitazone during islet cell transplants, Fernandez said.

The drug, manufactured by Takeda Pharmaceuticals North America Inc.,

sensitizes the body's cells to insulin, meaning that physicians may

be

able to use fewer cells to get the same effect, he said.

One pancreas typically has about 1 million cells, but only about

300,000

to 500,000 can be extracted for each surgery, Woodle said.

Procedures fairly new

Quigley was diagnosed with Type 1 diabetes at age 14, and had started

having problems controlling his blood sugar levels, in part because

he

could no longer tell when they were getting low.

He learned about the procedure after reading about initial

experiments in

Canada, and persuaded doctors here to try it.

Doctors at the University of Alberta in Edmonton, Canada, had revived

interest in islet cell transplantation by improving the technique and

producing results so dramatic in eight patients that the New England

Journal of Medicine released the study in 2000 before its print

publication.

At that point, seven of the patients had been free of insulin

injections

an average of 12 months, with one patient being injection-free for 15

months. The eighth patient had just had a final transplant three

months

before the study's release, but was also off insulin.

Doctors in UW's program have transplanted islet cells in three

patients,

including Quigley and 27-year-old Vissers of Waukesha.

Vissers had his first transplant on Oct. 2 and returned to work a

week

later. He says it's too early to determine its success. He'll

continue to

take his insulin four times a day until a second transplant.

At this point, UW physicians are unsure how long Quigley will be

insulin

injection-free, but are pleased with the results so far.

And Quigley says that after almost 42 years of giving himself a shot

three

times a day, he is pleased, too.

" I still have to stay healthy, but yes, I can be with my children and

stop

to get an ice cream cone or I can walk in the woods without having to

worry about bringing food or medicine along, " Quigley said. " There

are

some side effects that are good, like you don't have this thing in

the

back of your mind anymore. "

Congdon; Milwaukee Wisconsin USA

mailto:voyagerjc@...

Take care and may the force be with you!

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[Guest guest]

cool stuff!

Regards,

Interesting research

>

>

> Taken from this morning's Milwaukee Journal Sentinel

>

>

> Cell transplants at UW-Madison free diabetic from daily insulin

> injections

> By KAWANZA L. GRIFFIN

> kgriffin@...

> Posted: Oct. 29, 2004

> Madison - Dan Quigley is eating ice cream again.

> After three pancreatic islet cell transplants, the Door County man

> has

> become the first Wisconsin resident with Type 1 diabetes to be

> declared

> free of the need for insulin injections.

> Quigley, 55, threw out his insulin last week.

> " The first day not using it was not so much emotional, but I kept

> thinking, 'What am I missing?' and walking to the refrigerator to

> get

> a

> shot, " he said.

> Free from Injections

>

>

> Islet cell transplantation is an experimental procedure for people with

> Type 1 diabetes that is being performed at several research centers

> throughout the nation, including the University of Wisconsin-

> Madison.

> The procedure involves extraction of insulin-producing islet cells

> from

> donated pancreases that are then directly infused into the patient's

> liver.

> However, each patient needs cells from at least two donated

> pancreases,

> which are in short supply, said Jon Odorico, the UW surgeon who

> performed

> Quigley's procedures.

> " There are approximately 6,000 multi-organ cadaver donors each

> year, "

> he

> said. " Less than 50 percent, on average, donate a pancreas. "

> In addition, most pancreases - 1,600 - are used for transplants;

> fewer

> than 100 are used for islet cell extraction, Odorico said.

> Embryonic stem cells, such as the ones he grows in his lab, may

> someday

> provide a limitless supply of the special cells that make insulin,

> pancreatic islet beta cells. But for now, the cells are available

> only

> from donated organs.

> Quigley had his first transplant in September 2002, after which he

> was

> able to cut his insulin use in half, he said. The second transplant

> was in

> June 2003, followed by his final one this past July.

> He has now joined a handful of people who have been able to stop

> using

> insulin after treatment.

> People who have Type 1 diabetes, also known as juvenile diabetes,

> are

>

> unable to produce insulin, the hormone that helps convert sugar and

> starch

> to energy. Type 1 diabetics must take daily insulin shots as well as

> follow special diet and exercise programs.

> But despite treatment, many patients ultimately go blind, develop

> kidney

> failure or suffer other life-threatening complications.

> Transplant costs high

> Even with the islet cell advances, the cost to perform

> transplantation can

> be astronomical, said Steve Woodle, chief of the division of

> transplantation at University Hospital in Cincinnati and a professor

> of

> surgery at the University of Cincinnati.

> " It's great for Wisconsin, and it's certainly a big step for

> research

> and

> people with diabetes, " he said. " But it's not cheap. "

> Woodle said that one problem is the rising cost of donor

> pancreases -

> from

> $2,500 to $20,000 - which contribute to an average cost of $200,000

> to

> $250,000 per treatment, he said.

> As a result, the privately funded procedures at University Hospital

> are

> now " on hold " despite success in six patients, one of whom no longer

> needed insulin injections after just one transplant. That patient is

> still

> off insulin two years later.

> " (Cost is) a real problem, " Woodle said.

> UW's islet cell transplants are part of a clinical study funded by a

> pharmaceutical company and conducted by Odorico and colleague

> Fernandez. Both physicians are directors of the islet cell

> transplant

>

> program at UW.

> The purpose of the study is to determine the effectiveness of the

> drug

> pioglitazone during islet cell transplants, Fernandez said.

> The drug, manufactured by Takeda Pharmaceuticals North America Inc.,

> sensitizes the body's cells to insulin, meaning that physicians may

> be

> able to use fewer cells to get the same effect, he said.

> One pancreas typically has about 1 million cells, but only about

> 300,000

> to 500,000 can be extracted for each surgery, Woodle said.

> Procedures fairly new

> Quigley was diagnosed with Type 1 diabetes at age 14, and had

> started

>

> having problems controlling his blood sugar levels, in part because

> he

> could no longer tell when they were getting low.

> He learned about the procedure after reading about initial

> experiments in

> Canada, and persuaded doctors here to try it.

> Doctors at the University of Alberta in Edmonton, Canada, had

> revived

>

> interest in islet cell transplantation by improving the technique

> and

>

> producing results so dramatic in eight patients that the New England

> Journal of Medicine released the study in 2000 before its print

> publication.

> At that point, seven of the patients had been free of insulin

> injections

> an average of 12 months, with one patient being injection-free for

> 15

>

> months. The eighth patient had just had a final transplant three

> months

> before the study's release, but was also off insulin.

> Doctors in UW's program have transplanted islet cells in three

> patients,

> including Quigley and 27-year-old Vissers of Waukesha.

> Vissers had his first transplant on Oct. 2 and returned to work a

> week

> later. He says it's too early to determine its success. He'll

> continue to

> take his insulin four times a day until a second transplant.

> At this point, UW physicians are unsure how long Quigley will be

> insulin

> injection-free, but are pleased with the results so far.

> And Quigley says that after almost 42 years of giving himself a shot

> three

> times a day, he is pleased, too.

> " I still have to stay healthy, but yes, I can be with my children

> and

> stop

> to get an ice cream cone or I can walk in the woods without having

> to

>

> worry about bringing food or medicine along, " Quigley said. " There

> are

> some side effects that are good, like you don't have this thing in

> the

> back of your mind anymore. "

>

>

>

> Congdon; Milwaukee Wisconsin USA

> mailto:voyagerjc@...

> Take care and may the force be with you!

>

> ---

> Outgoing mail is certified Virus Free.

> Checked by AVG anti-virus system (http://www.grisoft.com).

> Version: 6.0.784 / Virus Database: 530 - Release Date: 10/27/2004

>

>

>

> ************************************************************

> * ACB-L is maintained and brought to you as a service *

> * of the American Council of the Blind. *

> --

> To unsubscribe, e-mail: acb-l-unsubscribe@...

> For additional commands, e-mail: acb-l-help@...

>

>

>

>

>

>

>

>

>

[Guest guest]

cool stuff!

Regards,

Interesting research

>

>

> Taken from this morning's Milwaukee Journal Sentinel

>

>

> Cell transplants at UW-Madison free diabetic from daily insulin

> injections

> By KAWANZA L. GRIFFIN

> kgriffin@...

> Posted: Oct. 29, 2004

> Madison - Dan Quigley is eating ice cream again.

> After three pancreatic islet cell transplants, the Door County man

> has

> become the first Wisconsin resident with Type 1 diabetes to be

> declared

> free of the need for insulin injections.

> Quigley, 55, threw out his insulin last week.

> " The first day not using it was not so much emotional, but I kept

> thinking, 'What am I missing?' and walking to the refrigerator to

> get

> a

> shot, " he said.

> Free from Injections

>

>

> Islet cell transplantation is an experimental procedure for people with

> Type 1 diabetes that is being performed at several research centers

> throughout the nation, including the University of Wisconsin-

> Madison.

> The procedure involves extraction of insulin-producing islet cells

> from

> donated pancreases that are then directly infused into the patient's

> liver.

> However, each patient needs cells from at least two donated

> pancreases,

> which are in short supply, said Jon Odorico, the UW surgeon who

> performed

> Quigley's procedures.

> " There are approximately 6,000 multi-organ cadaver donors each

> year, "

> he

> said. " Less than 50 percent, on average, donate a pancreas. "

> In addition, most pancreases - 1,600 - are used for transplants;

> fewer

> than 100 are used for islet cell extraction, Odorico said.

> Embryonic stem cells, such as the ones he grows in his lab, may

> someday

> provide a limitless supply of the special cells that make insulin,

> pancreatic islet beta cells. But for now, the cells are available

> only

> from donated organs.

> Quigley had his first transplant in September 2002, after which he

> was

> able to cut his insulin use in half, he said. The second transplant

> was in

> June 2003, followed by his final one this past July.

> He has now joined a handful of people who have been able to stop

> using

> insulin after treatment.

> People who have Type 1 diabetes, also known as juvenile diabetes,

> are

>

> unable to produce insulin, the hormone that helps convert sugar and

> starch

> to energy. Type 1 diabetics must take daily insulin shots as well as

> follow special diet and exercise programs.

> But despite treatment, many patients ultimately go blind, develop

> kidney

> failure or suffer other life-threatening complications.

> Transplant costs high

> Even with the islet cell advances, the cost to perform

> transplantation can

> be astronomical, said Steve Woodle, chief of the division of

> transplantation at University Hospital in Cincinnati and a professor

> of

> surgery at the University of Cincinnati.

> " It's great for Wisconsin, and it's certainly a big step for

> research

> and

> people with diabetes, " he said. " But it's not cheap. "

> Woodle said that one problem is the rising cost of donor

> pancreases -

> from

> $2,500 to $20,000 - which contribute to an average cost of $200,000

> to

> $250,000 per treatment, he said.

> As a result, the privately funded procedures at University Hospital

> are

> now " on hold " despite success in six patients, one of whom no longer

> needed insulin injections after just one transplant. That patient is

> still

> off insulin two years later.

> " (Cost is) a real problem, " Woodle said.

> UW's islet cell transplants are part of a clinical study funded by a

> pharmaceutical company and conducted by Odorico and colleague

> Fernandez. Both physicians are directors of the islet cell

> transplant

>

> program at UW.

> The purpose of the study is to determine the effectiveness of the

> drug

> pioglitazone during islet cell transplants, Fernandez said.

> The drug, manufactured by Takeda Pharmaceuticals North America Inc.,

> sensitizes the body's cells to insulin, meaning that physicians may

> be

> able to use fewer cells to get the same effect, he said.

> One pancreas typically has about 1 million cells, but only about

> 300,000

> to 500,000 can be extracted for each surgery, Woodle said.

> Procedures fairly new

> Quigley was diagnosed with Type 1 diabetes at age 14, and had

> started

>

> having problems controlling his blood sugar levels, in part because

> he

> could no longer tell when they were getting low.

> He learned about the procedure after reading about initial

> experiments in

> Canada, and persuaded doctors here to try it.

> Doctors at the University of Alberta in Edmonton, Canada, had

> revived

>

> interest in islet cell transplantation by improving the technique

> and

>

> producing results so dramatic in eight patients that the New England

> Journal of Medicine released the study in 2000 before its print

> publication.

> At that point, seven of the patients had been free of insulin

> injections

> an average of 12 months, with one patient being injection-free for

> 15

>

> months. The eighth patient had just had a final transplant three

> months

> before the study's release, but was also off insulin.

> Doctors in UW's program have transplanted islet cells in three

> patients,

> including Quigley and 27-year-old Vissers of Waukesha.

> Vissers had his first transplant on Oct. 2 and returned to work a

> week

> later. He says it's too early to determine its success. He'll

> continue to

> take his insulin four times a day until a second transplant.

> At this point, UW physicians are unsure how long Quigley will be

> insulin

> injection-free, but are pleased with the results so far.

> And Quigley says that after almost 42 years of giving himself a shot

> three

> times a day, he is pleased, too.

> " I still have to stay healthy, but yes, I can be with my children

> and

> stop

> to get an ice cream cone or I can walk in the woods without having

> to

>

> worry about bringing food or medicine along, " Quigley said. " There

> are

> some side effects that are good, like you don't have this thing in

> the

> back of your mind anymore. "

>

>

>

> Congdon; Milwaukee Wisconsin USA

> mailto:voyagerjc@...

> Take care and may the force be with you!

>

> ---

> Outgoing mail is certified Virus Free.

> Checked by AVG anti-virus system (http://www.grisoft.com).

> Version: 6.0.784 / Virus Database: 530 - Release Date: 10/27/2004

>

>

>

> ************************************************************

> * ACB-L is maintained and brought to you as a service *

> * of the American Council of the Blind. *

> --

> To unsubscribe, e-mail: acb-l-unsubscribe@...

> For additional commands, e-mail: acb-l-help@...

>

>

>

>

>

>

>

>

>

[Guest guest]

cool stuff!

Regards,

Interesting research

>

>

> Taken from this morning's Milwaukee Journal Sentinel

>

>

> Cell transplants at UW-Madison free diabetic from daily insulin

> injections

> By KAWANZA L. GRIFFIN

> kgriffin@...

> Posted: Oct. 29, 2004

> Madison - Dan Quigley is eating ice cream again.

> After three pancreatic islet cell transplants, the Door County man

> has

> become the first Wisconsin resident with Type 1 diabetes to be

> declared

> free of the need for insulin injections.

> Quigley, 55, threw out his insulin last week.

> " The first day not using it was not so much emotional, but I kept

> thinking, 'What am I missing?' and walking to the refrigerator to

> get

> a

> shot, " he said.

> Free from Injections

>

>

> Islet cell transplantation is an experimental procedure for people with

> Type 1 diabetes that is being performed at several research centers

> throughout the nation, including the University of Wisconsin-

> Madison.

> The procedure involves extraction of insulin-producing islet cells

> from

> donated pancreases that are then directly infused into the patient's

> liver.

> However, each patient needs cells from at least two donated

> pancreases,

> which are in short supply, said Jon Odorico, the UW surgeon who

> performed

> Quigley's procedures.

> " There are approximately 6,000 multi-organ cadaver donors each

> year, "

> he

> said. " Less than 50 percent, on average, donate a pancreas. "

> In addition, most pancreases - 1,600 - are used for transplants;

> fewer

> than 100 are used for islet cell extraction, Odorico said.

> Embryonic stem cells, such as the ones he grows in his lab, may

> someday

> provide a limitless supply of the special cells that make insulin,

> pancreatic islet beta cells. But for now, the cells are available

> only

> from donated organs.

> Quigley had his first transplant in September 2002, after which he

> was

> able to cut his insulin use in half, he said. The second transplant

> was in

> June 2003, followed by his final one this past July.

> He has now joined a handful of people who have been able to stop

> using

> insulin after treatment.

> People who have Type 1 diabetes, also known as juvenile diabetes,

> are

>

> unable to produce insulin, the hormone that helps convert sugar and

> starch

> to energy. Type 1 diabetics must take daily insulin shots as well as

> follow special diet and exercise programs.

> But despite treatment, many patients ultimately go blind, develop

> kidney

> failure or suffer other life-threatening complications.

> Transplant costs high

> Even with the islet cell advances, the cost to perform

> transplantation can

> be astronomical, said Steve Woodle, chief of the division of

> transplantation at University Hospital in Cincinnati and a professor

> of

> surgery at the University of Cincinnati.

> " It's great for Wisconsin, and it's certainly a big step for

> research

> and

> people with diabetes, " he said. " But it's not cheap. "

> Woodle said that one problem is the rising cost of donor

> pancreases -

> from

> $2,500 to $20,000 - which contribute to an average cost of $200,000

> to

> $250,000 per treatment, he said.

> As a result, the privately funded procedures at University Hospital

> are

> now " on hold " despite success in six patients, one of whom no longer

> needed insulin injections after just one transplant. That patient is

> still

> off insulin two years later.

> " (Cost is) a real problem, " Woodle said.

> UW's islet cell transplants are part of a clinical study funded by a

> pharmaceutical company and conducted by Odorico and colleague

> Fernandez. Both physicians are directors of the islet cell

> transplant

>

> program at UW.

> The purpose of the study is to determine the effectiveness of the

> drug

> pioglitazone during islet cell transplants, Fernandez said.

> The drug, manufactured by Takeda Pharmaceuticals North America Inc.,

> sensitizes the body's cells to insulin, meaning that physicians may

> be

> able to use fewer cells to get the same effect, he said.

> One pancreas typically has about 1 million cells, but only about

> 300,000

> to 500,000 can be extracted for each surgery, Woodle said.

> Procedures fairly new

> Quigley was diagnosed with Type 1 diabetes at age 14, and had

> started

>

> having problems controlling his blood sugar levels, in part because

> he

> could no longer tell when they were getting low.

> He learned about the procedure after reading about initial

> experiments in

> Canada, and persuaded doctors here to try it.

> Doctors at the University of Alberta in Edmonton, Canada, had

> revived

>

> interest in islet cell transplantation by improving the technique

> and

>

> producing results so dramatic in eight patients that the New England

> Journal of Medicine released the study in 2000 before its print

> publication.

> At that point, seven of the patients had been free of insulin

> injections

> an average of 12 months, with one patient being injection-free for

> 15

>

> months. The eighth patient had just had a final transplant three

> months

> before the study's release, but was also off insulin.

> Doctors in UW's program have transplanted islet cells in three

> patients,

> including Quigley and 27-year-old Vissers of Waukesha.

> Vissers had his first transplant on Oct. 2 and returned to work a

> week

> later. He says it's too early to determine its success. He'll

> continue to

> take his insulin four times a day until a second transplant.

> At this point, UW physicians are unsure how long Quigley will be

> insulin

> injection-free, but are pleased with the results so far.

> And Quigley says that after almost 42 years of giving himself a shot

> three

> times a day, he is pleased, too.

> " I still have to stay healthy, but yes, I can be with my children

> and

> stop

> to get an ice cream cone or I can walk in the woods without having

> to

>

> worry about bringing food or medicine along, " Quigley said. " There

> are

> some side effects that are good, like you don't have this thing in

> the

> back of your mind anymore. "

>

>

>

> Congdon; Milwaukee Wisconsin USA

> mailto:voyagerjc@...

> Take care and may the force be with you!

>

> ---

> Outgoing mail is certified Virus Free.

> Checked by AVG anti-virus system (http://www.grisoft.com).

> Version: 6.0.784 / Virus Database: 530 - Release Date: 10/27/2004

>

>

>

> ************************************************************

> * ACB-L is maintained and brought to you as a service *

> * of the American Council of the Blind. *

> --

> To unsubscribe, e-mail: acb-l-unsubscribe@...

> For additional commands, e-mail: acb-l-help@...

>

>

>

>

>

>

>

>

>