Guest guest Posted November 17, 2004 Report Share Posted November 17, 2004 just some FYI but gastroparesis is a form of neuropathy caused from high a1c levels over a period of time. Some have reported it to reverse once they got their a1c down to around 5 for a period of several months. Regards, article That means a larger gift of $100 can become $200 and a most generous donation of $250 can go twice as far in the battle against diabetes! Every donation to this campaign will be matched by Equal®, until we reach our goal of $50,000. A donation now can make double the difference. Please give. Donate now online or call toll-free at 1-800-DIABETES (1-) Learn more>> FEATURE ARTICLE... Botox for Stomach Problems? Diabetic neuropathy can lead to a condition called gastroparesis. Nerves that control the digestive system have been damaged, and food moves very slowly from the stomach to the small intestine. People with gastroparesis feel full after eating a small amount of food, and they may have nausea, vomiting, loss of appetite, unwanted weight loss, and stomach pain. Blood glucose levels are hard to control because the person can't predict when food will be digested. During a flare-up of gastroparesis, the person may essentially be homebound because of unpredictable vomiting. Various drugs are used to treat gastroparesis, with variable success, and these drugs may have side effects. The pylorus is the " doorway " that lets food pass from the stomach to the small intestine. It has been proposed that one aspect of gastroparesis is abnormally high pressure in the pylorus, which keeps food from passing easily. Researchers theorized that an injection of botulism toxin into the pylorus would paralyze that muscle and allow food to pass more easily. Eight patients with type 1 diabetes and gastroparesis volunteered for a study. All were getting only partial relief from standard medications. Their average age was 41 years, average duration of diabetes was 24 years. All had pyloric spasms. A doctor injected botulinum toxin (Botox) into each patient's pylorus. (One patient got a second injection nine weeks later.) Patients were called at home 24 hours after the injection and also asked at their follow-up appointments whether they had any complications from the injection. None were reported. Patients rated 12 symptoms (such as bloating, abdominal pain, nausea, vomiting) before their injections of Botox and at follow-up appointments. Average symptom scores of the eight patients before Botox was 27 out of a maximum score of 36. At 1, 4, 6, and 8 weeks after Botox, symptom scores ranged from 11 to 15. Stomach emptying studies were done by having the patients eat a standard meal labeled with radioisotope and timing how long it took for half the meal to pass from the stomach. One patient had a time of 142 minutes before injection and 82 minutes one week after the injection, a time that is within the normal range. Three patients had significant improvements: 182 min. down to 108 min., 351 min. down to 148 min., and 800 min. down to 278 min. Three patients did not have any significant change in the stomach-emptying half-times. One patient had an increase, but she reported that she felt better. Patients with severe gastroparesis often lose weight without wanting to, so weight gain is a good thing. At the 12-week follow-up, one patient's weight was unchanged, two patients had gained 1 to 4 pounds, one patient had gained 5 to 9 pounds, three patients had gained 10 or more pounds. The researchers call for large, double-blinded, placebo-controlled studies of Botox for the treatment of the often intractable problem of gastroparesis. Diabetes Care 27:2341-47, 2004 Quote Link to comment Share on other sites More sharing options...
Guest guest Posted November 17, 2004 Report Share Posted November 17, 2004 just some FYI but gastroparesis is a form of neuropathy caused from high a1c levels over a period of time. Some have reported it to reverse once they got their a1c down to around 5 for a period of several months. Regards, article That means a larger gift of $100 can become $200 and a most generous donation of $250 can go twice as far in the battle against diabetes! Every donation to this campaign will be matched by Equal®, until we reach our goal of $50,000. A donation now can make double the difference. Please give. Donate now online or call toll-free at 1-800-DIABETES (1-) Learn more>> FEATURE ARTICLE... Botox for Stomach Problems? Diabetic neuropathy can lead to a condition called gastroparesis. Nerves that control the digestive system have been damaged, and food moves very slowly from the stomach to the small intestine. People with gastroparesis feel full after eating a small amount of food, and they may have nausea, vomiting, loss of appetite, unwanted weight loss, and stomach pain. Blood glucose levels are hard to control because the person can't predict when food will be digested. During a flare-up of gastroparesis, the person may essentially be homebound because of unpredictable vomiting. Various drugs are used to treat gastroparesis, with variable success, and these drugs may have side effects. The pylorus is the " doorway " that lets food pass from the stomach to the small intestine. It has been proposed that one aspect of gastroparesis is abnormally high pressure in the pylorus, which keeps food from passing easily. Researchers theorized that an injection of botulism toxin into the pylorus would paralyze that muscle and allow food to pass more easily. Eight patients with type 1 diabetes and gastroparesis volunteered for a study. All were getting only partial relief from standard medications. Their average age was 41 years, average duration of diabetes was 24 years. All had pyloric spasms. A doctor injected botulinum toxin (Botox) into each patient's pylorus. (One patient got a second injection nine weeks later.) Patients were called at home 24 hours after the injection and also asked at their follow-up appointments whether they had any complications from the injection. None were reported. Patients rated 12 symptoms (such as bloating, abdominal pain, nausea, vomiting) before their injections of Botox and at follow-up appointments. Average symptom scores of the eight patients before Botox was 27 out of a maximum score of 36. At 1, 4, 6, and 8 weeks after Botox, symptom scores ranged from 11 to 15. Stomach emptying studies were done by having the patients eat a standard meal labeled with radioisotope and timing how long it took for half the meal to pass from the stomach. One patient had a time of 142 minutes before injection and 82 minutes one week after the injection, a time that is within the normal range. Three patients had significant improvements: 182 min. down to 108 min., 351 min. down to 148 min., and 800 min. down to 278 min. Three patients did not have any significant change in the stomach-emptying half-times. One patient had an increase, but she reported that she felt better. Patients with severe gastroparesis often lose weight without wanting to, so weight gain is a good thing. At the 12-week follow-up, one patient's weight was unchanged, two patients had gained 1 to 4 pounds, one patient had gained 5 to 9 pounds, three patients had gained 10 or more pounds. The researchers call for large, double-blinded, placebo-controlled studies of Botox for the treatment of the often intractable problem of gastroparesis. Diabetes Care 27:2341-47, 2004 Quote Link to comment Share on other sites More sharing options...
Guest guest Posted March 25, 2005 Report Share Posted March 25, 2005 Skip to Navigation In Diabetes Today 21-MAR-2005 Caffeine Impairs Sugar Metabolism NEW YORK (Reuters Health) - Caffeine intake makes insulin more resistant to changes in blood sugar levels, Canadian researchers report. This effect was observed both in patients with and those without diabetes and could not be reversed with regular exercise or weight. But before you throw away your coffee mug -- these results may not apply to the popular caffeinated beverage, the investigators note. In fact, previous research has suggested that drinking coffee may cut the risk of diabetes. When sugar levels in the blood get too high, insulin is released, which brings the levels back down. With insulin resistance, also known as decreased insulin sensitivity, sugar levels need to get much higher before insulin release is triggered. Over time, this resistance can cause problems and lead to diabetes. " Through mechanisms that have yet to be firmly established, caffeine attenuates any of the beneficial effects of exercise or weight loss on insulin resistance, " Dr. Ross of Queens University in Kingston, Ontario, told Reuters Health. While the clinical implications remain unclear, Ross added, the findings are a " red flag " for doctors and are particularly important for obese patients and those with diabetes. Ross and his team evaluated sugar metabolism in 23 men before and after a three-month exercise program. Before and during the exercise program, the men were given caffeine or inactive " placebo " . The subjects included eight sedentary lean men, seven obese men with type 2 diabetes, and eight obese men without diabetes. Before the exercise program, caffeine reduced insulin sensitivity by 33 percent in the lean and obese men and 37 percent in the men with diabetes compared to placebo. After the exercise program, insulin sensitivity fell 23 percent after caffeine intake in the lean men, 26 percent in the obese men, and 36 percent in the diabetic men. Comparison of the two study phases, showed that exercise did not improve insulin resistance related to caffeine intake. The findings, published in the medical journal Diabetes Care, seem to contradict recent reports that coffee intake may cut the risk of diabetes, Ross noted. However, coffee contains several other substances that may affect sugar metabolism, such as antioxidants, potassium and magnesium. " When you give somebody caffeine without all of the other substances that are in coffee you have a very different situation, " he added. SOURCE: Diabetes Care, March 2005. Quote Link to comment Share on other sites More sharing options...
Guest guest Posted April 7, 2005 Report Share Posted April 7, 2005 Excellent research article. If they want to know the long term effects of a low carbohydrate study, they should ask Dr. K. Bernstein, who limits himself to a total of 30 grams of carbs per day. He is a type 1 diabetic who is over 70 years of age and in excellent health and glucose control. Article > > Diabetes News - American Diabetes Association > > American Diabetes Association Home Page > > Search > > > > Go > > Skip to Navigation > > > > In Diabetes Today > > 31-MAR-2005 > > > > Study of Obese People with Diabetes Explains Why Low-Carb Diets Produce > Fast > Results > > > > A new study by Temple University School of Medicine researchers has shown > why the pounds melt so quickly on low-carbohydrate diets, and it's not > related > > to water, metabolism or boredom. The research was conducted in a group of > obese patients with type 2 diabetes who followed the Atkins diet. > > > > According to lead researcher, Guenther Boden, MD, " When carbohydrates were > restricted, study subjects spontaneously reduced their caloric intake to a > level > > appropriate for their height, did not compensate by eating more protein or > fat, and lost weight. We concluded that excessive overeating had been > fueled > > by carbohydrates. " > > > > Almost 80% of diabetics are overweight or obese, compounding health risks > such as heart disease and stroke. Boden wanted to examine how > low-carbohydrate > > diets, which have been shown to produce rapid weight loss, affected > weight, > appetite and blood sugar in obese diabetics. > > > > He discovered that study subjects did not eat less because they were bored > with the food selection, and their weight loss was not attributable to > water > > loss, two common speculations about low-carb diets. Further, weight loss > could not be explained by a change in metabolism, another popular > misconception. > > > > The study, " Short-term effects of low-carbohydrate diet compared with > usual > diet in obese patients with type 2 diabetes, " appeared in the ls of > Internal > > Medicine. It is the only study of the Atkins diet to have been conducted > in > the strictly controlled environment of a clinical research center where > every > > calorie eaten and spent was measured. > > > > After a week of typical eating, 10 obese patients with type 2 diabetes > followed the Atkins diet for 2 weeks, with carbohydrates limited to 20 g > per > day > > and unlimited protein and fat. > > > > " When we took away the carbohydrates, the patients spontaneously reduced > their daily energy consumption by 1000 calories a day. Although they could > have, > > they did not compensate by eating more proteins and fats and they weren't > bored with the food choices. In fact, they loved the diet. The > carbohydrates > > were clearly stimulating their excessive appetites, " said Boden. > > > > All patients stayed in the hospital for the length of the study to insure > exact measurements of calorie intake and expenditure. In other studies of > the > > Atkins diet, subjects were at home and reported their own diet and > exercise, > making it difficult to ensure accuracy. > > > > In addition to the calorie reduction and weight loss, subjects experienced > markedly improved glucose levels and insulin sensitivity, as well as lower > triglycerides > > and cholesterol. > > > > Treatment for diabetes centers on closely monitoring sugar levels, diet > and > medication. Weight loss can often reduce or eliminate the need for > medication, > > including insulin. > > > > Boden warned that the long-term effects of low-carbohydrate diets are not > known. Whether other types of diets would have a similar impact also > remains > to > > be investigated. > > > > This study was funding by grants from the National Institutes of Health > and > the American Diabetes Association. This article was prepared by Biotech > Week > > editors from staff and other reports. Copyright 2005, Biotech Week via > NewsRx.com. > > > > Quote Link to comment Share on other sites More sharing options...
Guest guest Posted April 7, 2005 Report Share Posted April 7, 2005 Excellent research article. If they want to know the long term effects of a low carbohydrate study, they should ask Dr. K. Bernstein, who limits himself to a total of 30 grams of carbs per day. He is a type 1 diabetic who is over 70 years of age and in excellent health and glucose control. Article > > Diabetes News - American Diabetes Association > > American Diabetes Association Home Page > > Search > > > > Go > > Skip to Navigation > > > > In Diabetes Today > > 31-MAR-2005 > > > > Study of Obese People with Diabetes Explains Why Low-Carb Diets Produce > Fast > Results > > > > A new study by Temple University School of Medicine researchers has shown > why the pounds melt so quickly on low-carbohydrate diets, and it's not > related > > to water, metabolism or boredom. The research was conducted in a group of > obese patients with type 2 diabetes who followed the Atkins diet. > > > > According to lead researcher, Guenther Boden, MD, " When carbohydrates were > restricted, study subjects spontaneously reduced their caloric intake to a > level > > appropriate for their height, did not compensate by eating more protein or > fat, and lost weight. We concluded that excessive overeating had been > fueled > > by carbohydrates. " > > > > Almost 80% of diabetics are overweight or obese, compounding health risks > such as heart disease and stroke. Boden wanted to examine how > low-carbohydrate > > diets, which have been shown to produce rapid weight loss, affected > weight, > appetite and blood sugar in obese diabetics. > > > > He discovered that study subjects did not eat less because they were bored > with the food selection, and their weight loss was not attributable to > water > > loss, two common speculations about low-carb diets. Further, weight loss > could not be explained by a change in metabolism, another popular > misconception. > > > > The study, " Short-term effects of low-carbohydrate diet compared with > usual > diet in obese patients with type 2 diabetes, " appeared in the ls of > Internal > > Medicine. It is the only study of the Atkins diet to have been conducted > in > the strictly controlled environment of a clinical research center where > every > > calorie eaten and spent was measured. > > > > After a week of typical eating, 10 obese patients with type 2 diabetes > followed the Atkins diet for 2 weeks, with carbohydrates limited to 20 g > per > day > > and unlimited protein and fat. > > > > " When we took away the carbohydrates, the patients spontaneously reduced > their daily energy consumption by 1000 calories a day. Although they could > have, > > they did not compensate by eating more proteins and fats and they weren't > bored with the food choices. In fact, they loved the diet. The > carbohydrates > > were clearly stimulating their excessive appetites, " said Boden. > > > > All patients stayed in the hospital for the length of the study to insure > exact measurements of calorie intake and expenditure. In other studies of > the > > Atkins diet, subjects were at home and reported their own diet and > exercise, > making it difficult to ensure accuracy. > > > > In addition to the calorie reduction and weight loss, subjects experienced > markedly improved glucose levels and insulin sensitivity, as well as lower > triglycerides > > and cholesterol. > > > > Treatment for diabetes centers on closely monitoring sugar levels, diet > and > medication. Weight loss can often reduce or eliminate the need for > medication, > > including insulin. > > > > Boden warned that the long-term effects of low-carbohydrate diets are not > known. Whether other types of diets would have a similar impact also > remains > to > > be investigated. > > > > This study was funding by grants from the National Institutes of Health > and > the American Diabetes Association. This article was prepared by Biotech > Week > > editors from staff and other reports. Copyright 2005, Biotech Week via > NewsRx.com. > > > > Quote Link to comment Share on other sites More sharing options...
Guest guest Posted April 7, 2005 Report Share Posted April 7, 2005 Excellent research article. If they want to know the long term effects of a low carbohydrate study, they should ask Dr. K. Bernstein, who limits himself to a total of 30 grams of carbs per day. He is a type 1 diabetic who is over 70 years of age and in excellent health and glucose control. Article > > Diabetes News - American Diabetes Association > > American Diabetes Association Home Page > > Search > > > > Go > > Skip to Navigation > > > > In Diabetes Today > > 31-MAR-2005 > > > > Study of Obese People with Diabetes Explains Why Low-Carb Diets Produce > Fast > Results > > > > A new study by Temple University School of Medicine researchers has shown > why the pounds melt so quickly on low-carbohydrate diets, and it's not > related > > to water, metabolism or boredom. The research was conducted in a group of > obese patients with type 2 diabetes who followed the Atkins diet. > > > > According to lead researcher, Guenther Boden, MD, " When carbohydrates were > restricted, study subjects spontaneously reduced their caloric intake to a > level > > appropriate for their height, did not compensate by eating more protein or > fat, and lost weight. We concluded that excessive overeating had been > fueled > > by carbohydrates. " > > > > Almost 80% of diabetics are overweight or obese, compounding health risks > such as heart disease and stroke. Boden wanted to examine how > low-carbohydrate > > diets, which have been shown to produce rapid weight loss, affected > weight, > appetite and blood sugar in obese diabetics. > > > > He discovered that study subjects did not eat less because they were bored > with the food selection, and their weight loss was not attributable to > water > > loss, two common speculations about low-carb diets. Further, weight loss > could not be explained by a change in metabolism, another popular > misconception. > > > > The study, " Short-term effects of low-carbohydrate diet compared with > usual > diet in obese patients with type 2 diabetes, " appeared in the ls of > Internal > > Medicine. It is the only study of the Atkins diet to have been conducted > in > the strictly controlled environment of a clinical research center where > every > > calorie eaten and spent was measured. > > > > After a week of typical eating, 10 obese patients with type 2 diabetes > followed the Atkins diet for 2 weeks, with carbohydrates limited to 20 g > per > day > > and unlimited protein and fat. > > > > " When we took away the carbohydrates, the patients spontaneously reduced > their daily energy consumption by 1000 calories a day. Although they could > have, > > they did not compensate by eating more proteins and fats and they weren't > bored with the food choices. In fact, they loved the diet. The > carbohydrates > > were clearly stimulating their excessive appetites, " said Boden. > > > > All patients stayed in the hospital for the length of the study to insure > exact measurements of calorie intake and expenditure. In other studies of > the > > Atkins diet, subjects were at home and reported their own diet and > exercise, > making it difficult to ensure accuracy. > > > > In addition to the calorie reduction and weight loss, subjects experienced > markedly improved glucose levels and insulin sensitivity, as well as lower > triglycerides > > and cholesterol. > > > > Treatment for diabetes centers on closely monitoring sugar levels, diet > and > medication. Weight loss can often reduce or eliminate the need for > medication, > > including insulin. > > > > Boden warned that the long-term effects of low-carbohydrate diets are not > known. Whether other types of diets would have a similar impact also > remains > to > > be investigated. > > > > This study was funding by grants from the National Institutes of Health > and > the American Diabetes Association. This article was prepared by Biotech > Week > > editors from staff and other reports. Copyright 2005, Biotech Week via > NewsRx.com. > > > > Quote Link to comment Share on other sites More sharing options...
Guest guest Posted April 8, 2005 Report Share Posted April 8, 2005 Gee, where would all the fun of research be if we started to mention someone like Dr. Bernstein, who is a good example already of what the " studies " are showing? Bill Quote Link to comment Share on other sites More sharing options...
Guest guest Posted April 8, 2005 Report Share Posted April 8, 2005 Gee, where would all the fun of research be if we started to mention someone like Dr. Bernstein, who is a good example already of what the " studies " are showing? Bill Quote Link to comment Share on other sites More sharing options...
Guest guest Posted April 8, 2005 Report Share Posted April 8, 2005 Gee, where would all the fun of research be if we started to mention someone like Dr. Bernstein, who is a good example already of what the " studies " are showing? Bill Quote Link to comment Share on other sites More sharing options...
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