UroToday - Alcohol Consumption and the Risk for Prostate Cancer in the European Prospective Investigation into Cancer and Nutrition - Abstract

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Friday, 30 May 2008

Division

of Cancer Epidemiology (C020), Im Neuenheimer Feld 280, 69120 Heidelberg, Germany.

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Alcohol

is a risk factor for several types of cancer. However, the results for prostate

cancer have been inconsistent, with most studies showing no association. Within

the European Prospective Investigation into Cancer and Nutrition, detailed

information were collected from 142,607 male participants on the intake of

alcoholic beverages at recruitment (for 100% of the cohort) and over lifetime

(for 76% of the cohort) between 1992 and 2000. During a median follow-up of 8.7

years, 2,655 prostate cancer cases were observed. Multivariate proportional

hazard models were used to examine the association of alcohol consumption at

recruitment and average lifetime alcohol consumption with prostate cancer

adjusted for age, center, smoking, height, weight, physical activity, and

nonalcohol energy intake. Overall, neither alcohol consumption at baseline nor

average lifetime alcohol consumption was associated with the risk for prostate

cancer in this cohort of men. Men who consumed >/=60 g alcohol per day had a

relative risk of 0.88 [95% confidence interval (95% CI) 0.72-1.08] compared

with men with an intake of 0.1-4.9 g/d; the respective relative risk for

average lifetime intake was 1.09 (95% CI, 0.86-1.39). For advanced prostate

cancer (n = 537), the relative risks for >/=60 and 0.1-4.9 g alcohol per day

at baseline were 0.98 (95% CI, 0.66-1.44) and 1.28 (95% CI, 0.79-2-07),

respectively, for average lifetime intake. No statistically significant

association was observed for alcohol intake from specific alcoholic beverages.

Our results indicate no association between the consumption of alcohol and

prostate cancer in this cohort of European men.

Written

by

Rohrmann S, Linseisen J, Key TJ, Jensen MK, Overvad K, sen NF, Tjønneland

A, Kaaks R, Bergmann MM, Weikert C, Naska A, Trichopoulou A, Trichopoulos D,

Pala V, Sacerdote C, Palli D, Tumino R, Bueno-de-Mesquita HB, Vrieling A,

González CA, Larrañaga N, Navarro C, Barricarte A, Quiros JR, Martínez-García

C, Hallmans G, Stattin P, Manjer J, Wirfält E, Bingham S, Khaw KT, Egevad L, Ferrari

P, Jenab M, Riboli E.

Reference

Cancer

Epidemiol Biomarkers Prev. 2008 May;17(5):1282-7.

PubMed

Abstract

PMID:18483352