SchaferAutismReport: Thimerosal Increases Risk of Neurotoxicity: Paper

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Tuesday, May 27, 2008 Reader Supported Vol. 12 No. 78p

In This Issue:

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RESEARCHThimerosal Increases Risk of Neurotoxicity: Paper

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PEOPLEFive-year-old Child With Aspergers' Voted Out of ClassReport Provides New Details About Autistic Teen's Death

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EDUCATIONSpecial Education Controversy: Consent Would Not Be Required

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TREATMENTAutism Portable Hug

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ADVOCACYContinuing "Vaccine Court" HearingsLETTERS

RESEARCHThimerosal Increases Risk of Neurotoxicity: PaperNeurotoxic Effects of Thimerosal At Vaccines Doses On The Encephalon And Development In 7 Days-Old HamstersAnales de la Facultad de Medicina ISSN 1025 - 5583 Universidad Nacional Mayor de San Marcos Pág. 222 - 237Jonny te 1, Fany Remuzgo 1, Betthina Ãvalos 1, nie Chiquinta 1, Bladimir Ponce 1, Avendaño 1, Maya 2,3 Abstract Objectives: To determine if thimerosal administration in amounts equivalent to vaccines content produces neurotoxic effects on the encephalon in postnatal hamsters and on experimentation animal’s development. Design: Experimental, prospective, bioetapic study. Setting: San Faculty of Medicine, Universidad Nacional Mayor de San Marcos. Biological material: Seven daysold hamsters. Material: We divided 45 postnatal hamsters in three groups: group A (n=15), group B (n=15) and group C (n=15). We administered three intramuscular equivalent doses of sucrose and thimerosal in 20 μL of saline to groups B and C, respectively, on birth-days 7 (0,227 μg), 9 (0,216 μg) and 11 (0,220 μg). Group A received only 20 μL of saline solution. Main outcome measures: Body weight, encephalon weight, height (skull-caudal length), and encephalon histopathological alterations. Results: Anova and student t tests showed statistical significance in favor of low body weight, low encephalon weight, and smaller stature in group C with respect to groups A and B hamsters (p<0,0001). X2 statistical significance in relation to the presence of hystopathological alterations in group C was also obtained (p<0,0001). We observed greater relative risk of encephalic alterations in group C. Conclusions: The administration of thimerosal in equivalent doses to vaccines content was associated with low corporal weight, low encephalon weight, and smaller stature in postnatal hamsters. Neurotoxic effects were also produced at encephalic level: at hippocampus (regions CA1, CA3 and DG), cerebral cortex, and cerebellum (Purkinje cells and granulose cells); with decrease in neuronal density, neuronal necrosis, axonal demyelinization, and gliosis. In addition, risk increase in developing any of these alterations was high just in the animal group receiving thimerosal.+ Read complete paper here: www.sarnet.org/lib/ATT01062.pdf

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