Guest guest Posted December 31, 2000 Report Share Posted December 31, 2000 This seemed somewhat interesting in that there was a tendency for the better quality linings to take longer to start the withdrawal bleeding after stopping progesterone (provera). Not in all cases, but at least a tendency. So those who are on hormone treatment, it might be a better sign if it takes longer to start bleeding after stopping the provera. Starting to bleed quickly after stopping the provera can be a sign of an atrophic lining. And of course, no bleeding--well, we know what that usually means. Terri http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve & db=PubMed & list_uid\ s=10714910 & dopt=Abstract PubMed Nucleotide Protein Genome Structure PopSet Taxonomy OMIM Search PubMed Protein Nucleotide Structure Genome PopSet OMIM Taxonomy for Limits Preview/Index History Clipboard About Entrez Entrez PubMed Overview Help | FAQ New/Noteworthy PubMed Services Journal Browser MeSH Browser Single Citation Matcher Batch Citation Matcher Clinical Queries Cubby Related Resources Order Documents Grateful Med Consumer Health Clinical Alerts ClinicalTrials.gov Privacy Policy Summary Brief Abstract Citation MEDLINE ASN.1 XML/SGML LinkOut Related Articles Protein Links Nucleotide Links Popset Links Structure Links Genome Links OMIM Links 1: Maturitas 2000 Feb 15;34(2):155-60 Related Articles, Books, LinkOut Can endometrial protection be inferred from the bleeding pattern on combined cyclical hormone replacement therapy.Burch D, Bieshuevel E, S, Fox HDepartment of Obstetrics and Gynaecology, Rosie Maternity Hospital, Cambridge, UK.OBJECTIVE: To investigate the relationship between the timing of withdrawal bleeding on hormone replacement therapy and the state of the endometrium. DESIGN: Double-blind, prospectively randomised dose-ranging study. SETTING: Menopause clinics in the UK and the Netherlands. SUBJECTS: Two hundred and seventy one postmenopausal women aged 40-60. INTERVENTIONS: Administration of six 28-day treatment cycles of a continuous daily dose of 2 mg of micronised 17beta oestradiol with a randomly allocated dose of 5-20 mg of dydrogesterone added for the last 14 days of each. METHODS: Comparison of the timing of the withdrawal bleed recorded in subject-held diaries with an endometrial biopsy obtained toward the end of the last cycle. RESULTS: There was a trend towards later withdrawal bleeding with secretory endometrium and earlier bleeding with inactive or atrophic endometrium, but with too much overlap for this to be of clinical relevance. There were two cases of proliferative and one of hyperplastic endometrium, with no characteristic bleeding pattern. CONCLUSION: Combined sequential HRT with progestogen given for 12-14 days very rarely fails to protect the endometrium. Such failures can not be detected by noting the bleeding pattern. The only suspicious pattern is non-cyclic bleeding, but this will not detect every case of hyperplasia or persistent proliferative endometrium.Publication Types: Clinical trial Randomized controlled trial PMID: 10714910, UI: 20177392 Summary Brief Abstract Citation MEDLINE ASN.1 XML/SGML LinkOut Related Articles Protein Links Nucleotide Links Popset Links Structure Links Genome Links OMIM Links Write to the Help Desk NCBI | NLM | NIH Department of Health & Human Services Freedom of Information Act | Disclaimer Quote Link to comment Share on other sites More sharing options...
Recommended Posts
Join the conversation
You are posting as a guest. If you have an account, sign in now to post with your account.
Note: Your post will require moderator approval before it will be visible.