Oral glutamine and type 2 diabetic subjects

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Reference: " Oral glutamine increases circulating Glucagons-like peptide

1, Glucagons, and insulin concentrations in lean, obese, and type 2

diabetic subjects, " Greenfield JR, Farooqi IS, et al, Am J Clin Nutr,

2009; 89(1): 106-13. (Address: FM Gribble, Cambridge Institute for

Medical Research and Department of Clinical Biochemistry, Wellcome

Trust/MRC Building, Hills Road, Cambridge CB2 0XY, United Kingdom.

E-mail: fmg23@... ).

Summary: In a study involving 8 healthy, normal-weight subjects, 8

obese subjects with type 2 diabetes or impaired glucose tolerance, and 8

nondiabetic obese subjects (who acted as controls), supplementation with

glutamine (30 g) was found to increase circulating concentrations of

glucagons-like peptide 1 (GLP-1) (which plays a role in meal-related

insulin secretion), which peaked at 30 minutes in normal-weight and

non-diabetic controls, and 45 minutes in obese diabetic subjects.

Glutamine was also found to increase plasma concentrations of

glucose-dependent insulinotropic polypeptide, which also plays a role in

meal-related insulin secretion. Moreover, glutamine significantly

increased circulating plasma insulin concentrations, and stimulated

glucagons secretion in all study groups. The authors conclude,

" Glutamine effectively increases circulating GLP-1, GIP, and insulin

concentrations in vivo and may represent a novel therapeutic approach to

stimulating insulin secretion in obesity and type 2 diabetes. "

--

ne Holden, MS, RD

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