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For fats, longer may not be better

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Colleagues, the following is FYI and does not necessarily reflect my own

opinion. I have no further knowledge of the topic. If you do not wish to

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Public release date: 8-Jan-2009

http://www.eurekalert.org/pub_releases/2009-01/asfb-ffl010809.php

Contact: Nick Zagorski

nzagorski@...

American Society for Biochemistry and Molecular Biology

For fats, longer may not be better

Appearing in the January issue of JLR

Researchers have uncovered why some dietary fats, specifically

long-chain fats, such as oleic acid (found in olive oil), are more prone

to induce inflammation. Long-chain fats, it turns out, promote increased

intestinal absorption of pro-inflammatory bacterial molecules called

lipopolysaccharides (LPS). This study appears in the January issue of JLR.

While dietary fats that have short chains (such as those found in milk

and cheese products) can be absorbed directly into the bloodstream from

the intestines, long-chain fats need to be first packaged by the

intestinal cells into particles known as chylomicrons (large complexes

similar to HDL and LDL particles). Eckhardt and colleagues at the

University of Kentucky wondered whether some unwanted LPS particles,

routinely shed by the bacteria that inhabit the human gut, might also be

sneaking in the chylomicrons.

Their hypothesis turned out to be correct; when they treated cultured

human intestinal cells with oleic acid they observed significant

secretion of LPS together with the chylomicron particles, a phenomenon

that was not observed when the cells were treated with short-chain

butyric acid. Similar findings were found in mouse studies; high amounts

of dietary oleic acid, but not butyric acid, promoted significant

absorption of LPS into the blood and lymph nodes and subsequent

expression of inflammatory genes.

Eckhardt and colleagues believe these findings may pave the way for

future therapies for Crohn's disease and other inflammatory bowel

disorders. In addition, they note that this study once again highlights

the importance of the diverse bacteria that call our intestines home.

###

From the article: " Chylomicrons promote intestinal absorption of

lipopolysaccharides " by Sarbani Ghoshal, Jassir Witta, Jian Zhong,

Willem de Villiers and Eckhardt

Article link: http://www.jlr.org/cgi/content/full/50/1/90

Corresponding Author: Eckhardt, Department of Internal Medicine,

University of Kentucky, Lexington. Tel: * 81741; email:

eeckh2@...

Note: This article also features a commentary available at

http://www.jlr.org/cgi/content/full/50/1/1

--

ne Holden, MS, RD

" Ask the Parkinson Dietitian " http://www.parkinson.org/

" Eat well, stay well with Parkinson's disease "

" Parkinson's disease: Guidelines for Medical Nutrition Therapy "

http://www.nutritionucanlivewith.com/

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