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Do Not Self-treat with Vitamin D

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>Thank you for the response Dr. Rolla. I will take a

>200 unit Vitamin D supplement and see if that helps.

>The 1-25 di Hydroxy vitamin D test was the one that

>they took when they found my levels so low.(5)

>Thanks again for your speedy response.

Dear ThyCa Members:

For those thyroid cancer patients unfortunate to have

hypoparathyroidism, requiring medication to avoid spontaneous low

calcium levels, self-medication is extraordinarily bad practice.

This requires detailed interaction and knowledge of a skilled

physician in order to prevent acute and chronic complications.

Vitamin D derivatives and analogs are not interchangeable. Each of

the Vitamin D metabolites have different pharmacokinetics so that

their dosage, time of onset, length of activity, and management of

toxicity are totally different. For example, the onset of activity

of Vitamin D2 (ergocalciferol) is 30 days while that of

1,25-dihydroxyvitamin D3 (calcitriol; Rocaltrol®) is 3 days. There

are at least 3 additional different vitamin D preparations with

kinetics between these two extremes. Self-underdosing is very

common, causing unrelenting hypocalcemia, while over-dosing, causing

unrelenting hypercalcemia, can be catastrophic. In addition, the

vitamin D component of therapy is ineffective if not accompanied by

sufficient and accurately titrated oral calcium preparations. Even

some physicians find some cases of hypoparathyroidism very difficult

to treat. Certainly this should not be attempted by an inexpert

patient without professional guidance.

--

**************PLEASE BE ADVISED*********************

THE INFORMATION CONTAINED IN THIS COMMUNICATION IS INTENDED

FOR EDUCATIONAL PURPOSES ONLY. IT IS NOT INTENDED, NOR SHOULD

IT BE CONSTRUED, AS SPECIFIC MEDICAL ADVICE OR DIRECTIONS. ANY

PERSON VIEWING THIS INFORMATION IS ADVISED TO CONSULT THEIR OWN

PHYSICIAN(S) ABOUT ANY MATTER REGARDING THEIR MEDICAL CARE.

************************************************

B. Ain, M.D.

Professor of Internal Medicine

Director, Thyroid Nodule & Oncology Clinical Service

Director, Thyroid Cancer Research Laboratory

Division of Endocrinology and Molecular Medicine

Department of Internal Medicine, Room MN524

University of Kentucky Medical Center

800 Rose Street, Lexington, Kentucky 40536-0298

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