Breast Ca: CoQ10, Niacin, and Riboflavin Improve Blood Chemistry Profiles Affected by Tamoxifen Therapy

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In Postmenopausal Breast Cancer Patients, Supplementation with Coenzyme

Q10, Niacin, and Riboflavin Improves Various Blood Chemistry Profiles

Unfavorably Affected by Tamoxifen Therapy

http://www.vitasearch.com/CP/weeklyupdates/

Reference: " Effect of Coenzyme Q(10), Riboflavin and Niacin on

Tamoxifen treated postmenopausal breast cancer women with special

reference to blood chemistry profiles, " Yuvaraj S, Premkumar VG, et al,

Breast Cancer Res Treat, 2008; [Epub ahead of print]. (Address:

Department of Medical Biochemistry, Dr. ALMP-GIBMS, University of

Madras, Taramani Campus, Chennai, 600 113, Tamil Nadu, India).

Summary: In a study involving 78 postmenopausal breast cancer patients

receiving tamoxifen therapy and 46 healthy controls, supplementation

with coenzyme Q10 (100 mg), niacin (50 mg), and riboflavin (10 mg) for a

period of 90 days was found to favorably impact blood chemistry profiles

negatively affected by tamoxifen (a chemotherapy drug). Blood samples

were collected at baseline, on the 45th and on the 90th day, and various

blood chemistry profiles were assessed. Tamoxifen therapy was found to

unfavorably affect various blood chemistry parameters, such as serum

total bilirubin, serum glutamate oxaloacetate transaminase, serum

glutamate pyruvate transaminase, gamma glutamyl transpeptidase, uric

acid, lipoprotein lipase, lecithin: cholesterol acyl transferases

(LCAT), potassium, calcium and Na(+), K(+)-ATPase. Supplementation with

coenzyme Q10, riboflavin and niacin (CoRN) was found to favorably

reverse these variou s blood chemistry parameters to near normal levels,

particularly liver and lipid parameters. Thus, the results of this study

suggest that postmenopausal breast cancer patients who are receiving

tamoxifen therapy may benefit from supplementation with a combination of

coenzyme Q10, riboflavin, and niacin.

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