For Sue

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Well this shows that hydrocortisone can be used in renal transplant patients

..............

Prednisone and prednisolone bioavailability in renal transplant patients.

Gambertoglio JG, Frey FJ, Holford NH, Birnbaum JL, Lizak PS, i F,

Feduska NJ, Salvatierra O Jr, Amend WJ Jr.

Prednisone and prednisolone are drugs with the potential for therapeutic

inequivalence due to bioavailability problems. The objective of our study

was to compare the systemic bioavailability of prednisolone from oral

prednisone and prednisolone. Nine kidney transplant patients receiving

prednisone (12.5 to 22.5 mg per day) were administered, in a randomized

fashion, the same dose of oral prednisone (Deltasone), oral prednisolone

(Delta-cortef) and intravenous prednisolone (Hydeltrasol). Prednisolone and

prednisone levels were measured using a specific high-pressure liquid

chromatographic assay. Since prednisolone exhibits dose-dependent

pharmacokinetics because of nonlinear plasma protein binding,

bioavailability from oral prednisone and oral prednisolone, compared to the

intravenous dose, was 84.5 +/- 17.8% and 95.5 +/- 17.6% using unbound drug

concentrations. These differences were not statistically significant.

Furthermore, no significant differences were observed between the two oral

formulations in peak prednisolone levels, time of peak levels or half-life

using either total or unbound drug concentrations. The results from our

study indicate that both of the oral preparations tested provide similar

bioavailability of active prednisolone and the conversion of prednisone to

prednisolone occurs rapidly.

Publication Types:

Clinical Trial

Randomized Controlled Trial

PMID: 7047863 [PubMed - indexed for MEDLINE]

Peace, Love and Harmony,

Bev