Vitamin D -Fall and Fracture prevention -Good abstract

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Vitamin D Supplementation - Recommended Dosages

http://www.vitasearch.com/CP/weeklyupdates/

Reference: “Benefit-risk assessment of vitamin D supplementation,â€

Bischoff-Ferrari HA, Shao A, et al, Osteoporos Int, 2009 Dec 3; [Epub

ahead of print]. (Address: Centre on Aging and Mobility, Department of

Rheumatology and Institute of Physical Medicine, University Hospital

Zurich, Gloriastrasse 25, 8091, Zurich, Switzerland. E-mail:

Heike.Bischoff@... ).

Summary: In a review of randomized, double-blind, controlled trials

assessing the effects of higher dose vitamin D and higher 25(OH)D level

and prevention of falls and fractures, a significant dose-response

relationship was observed between higher dose of vitamin D and higher

25(OH)D level and greater prevention of falls and fractures. Data from a

total of 44,705 subjects was analyzed. The greatest effects were found

for the highest dose of vitamin D tested (700-1000 IU/d) and the highest

levels of 25(OH)D (75-110 nmol/l) achieved. The authors conclude, “Our

analysis suggests that mean serum 25(OH)D levels of about 75 to 110

nmol/l provide optimal benefits for all investigated endpoints without

increasing health risks. These levels can be best obtained with oral

doses in the range of 1,800 to 4,000 IU vitamin D per day....â€

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Jan Patenaude, RD, CLT

Consultant, Writer, Speaker

Director of Medical Nutrition

Signet Diagnostic Corporation

(Mountain Time)

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