Guest guest Posted July 7, 1999 Report Share Posted July 7, 1999 Kathy, I am so sorry for your mom and your own pain. I am glad someone is looking at the autism/mito connection. I swear tonite if someone somewhere does not find something to help us help these kids we're all going to go under. LInda S. Re: DNA mutation >> Date: Saturday, June 26, 1999 5:01 PM >> >> From: Arrants@... >> >> In a message dated 6/26/1999 12:06:52 PM Eastern Daylight Time, >> joelinda@... writes: >> >> > >> > >> > All right Jeannine, If I understand this explanation, then if we have >a >> > membrane defect caused by a nuclear DNA defect it could be affecting >the >> > mitochondria but would be more accurately called an inborn error of >> > metabolism than specifically a mito disorder. >> >> > Does this sound like I'm on the right track here? Anyone who has an >idea or >> > comment is welcome to respond. >> >> I've been through some of this because of my own diagnosis, and I >presented >> almost the same question to the MDA neurologist I see. >> >> My situation is that I have a nuclear defect (MTM) that is not normally >> considered a mito. disorder, and yet, according to some research, MTM >> sometimes is accompanied by an OXPHOS disorder, which is true in my case. >I >> have several abnormal Complexes, which I'd have to dig out again to >recall >> which ones. Four out of the five tested were abnormal, I think. Yet the >> mitochondrial DNA is fine...it's all nuclear. >> >> So I asked my neurologist, " So do I have a mitochondrial disorder or >not? " >> and he said that it really depends on which doctor you ask, because this >> whole field is so new, one researcher's definition often will differ from > >> another's. >> >> the Elder, who has a mito. disorder, or not, or.... >> >> --------------------------- Quote Link to comment Share on other sites More sharing options...
Guest guest Posted July 10, 1999 Report Share Posted July 10, 1999 Laurie, I was wrong. Dr. DiMauro is looking at the mito DNA, not the nucleus DNA in this study we are in and looking for the autism link. Bart and I had our blood taken on wednesday. My daughter unfortunatley was to scared. (she is 11). That would have been a help for research to look at why she is unaffected and Bart is with autism. Dr. said she wishes the test was looking at the DNA. Thx for your explanation of the two. Kathy Foley ---------- > > To: Mitoonelist > Subject: Re: DNA mutation > Date: Wednesday, July 07, 1999 2:34 AM > > > > Kathy- > > Each cell has one nucleus which has the majority of our DNA. Half of it comes from the mother and half > from the father. Also in that cell are several to hundreds of mitochondria. The mito have their own DNA > which only comes from the mother. Some mito in this cell may be very healthy, with no defects and some > may be very sick, with major defects. > > I hope this helps. > > Laurie > > Hi, I am only on A right now and will surely be enlighted as I read on, but > > > this came up today and between my 3 year old nephew visiting, my mom > > diagnosed with return of breast cancer and my daughter , I had trouble > > hearing my son's Dr. She was trying to give me this same explanation.HOw > > does nuclear mitochondria differ from regular mitochondria in the cell. > > > > > --------------------------- Quote Link to comment Share on other sites More sharing options...
Guest guest Posted July 10, 1999 Report Share Posted July 10, 1999 Laurie, I was wrong. Dr. DiMauro is looking at the mito DNA, not the nucleus DNA in this study we are in and looking for the autism link. Bart and I had our blood taken on wednesday. My daughter unfortunatley was to scared. (she is 11). That would have been a help for research to look at why she is unaffected and Bart is with autism. Dr. said she wishes the test was looking at the DNA. Thx for your explanation of the two. Kathy Foley ---------- > > To: Mitoonelist > Subject: Re: DNA mutation > Date: Wednesday, July 07, 1999 2:34 AM > > > > Kathy- > > Each cell has one nucleus which has the majority of our DNA. Half of it comes from the mother and half > from the father. Also in that cell are several to hundreds of mitochondria. The mito have their own DNA > which only comes from the mother. Some mito in this cell may be very healthy, with no defects and some > may be very sick, with major defects. > > I hope this helps. > > Laurie > > Hi, I am only on A right now and will surely be enlighted as I read on, but > > > this came up today and between my 3 year old nephew visiting, my mom > > diagnosed with return of breast cancer and my daughter , I had trouble > > hearing my son's Dr. She was trying to give me this same explanation.HOw > > does nuclear mitochondria differ from regular mitochondria in the cell. > > > > > --------------------------- Quote Link to comment Share on other sites More sharing options...
Guest guest Posted July 10, 1999 Report Share Posted July 10, 1999 Laurie, I was wrong. Dr. DiMauro is looking at the mito DNA, not the nucleus DNA in this study we are in and looking for the autism link. Bart and I had our blood taken on wednesday. My daughter unfortunatley was to scared. (she is 11). That would have been a help for research to look at why she is unaffected and Bart is with autism. Dr. said she wishes the test was looking at the DNA. Thx for your explanation of the two. Kathy Foley ---------- > > To: Mitoonelist > Subject: Re: DNA mutation > Date: Wednesday, July 07, 1999 2:34 AM > > > > Kathy- > > Each cell has one nucleus which has the majority of our DNA. Half of it comes from the mother and half > from the father. Also in that cell are several to hundreds of mitochondria. The mito have their own DNA > which only comes from the mother. Some mito in this cell may be very healthy, with no defects and some > may be very sick, with major defects. > > I hope this helps. > > Laurie > > Hi, I am only on A right now and will surely be enlighted as I read on, but > > > this came up today and between my 3 year old nephew visiting, my mom > > diagnosed with return of breast cancer and my daughter , I had trouble > > hearing my son's Dr. She was trying to give me this same explanation.HOw > > does nuclear mitochondria differ from regular mitochondria in the cell. > > > > > --------------------------- Quote Link to comment Share on other sites More sharing options...
Guest guest Posted July 10, 1999 Report Share Posted July 10, 1999 But could the next step be looking at the DNA maybe? Re: DNA mutation >> Date: Wednesday, July 07, 1999 2:34 AM >> >> >> >> Kathy- >> >> Each cell has one nucleus which has the majority of our DNA. Half of it >comes from the mother and half >> from the father. Also in that cell are several to hundreds of >mitochondria. The mito have their own DNA >> which only comes from the mother. Some mito in this cell may be very >healthy, with no defects and some >> may be very sick, with major defects. >> >> I hope this helps. >> >> Laurie >> >> Hi, I am only on A right now and will surely be enlighted as I read on, >but >> >> > this came up today and between my 3 year old nephew visiting, my mom >> > diagnosed with return of breast cancer and my daughter , I had trouble >> > hearing my son's Dr. She was trying to give me this same >explanation.HOw >> > does nuclear mitochondria differ from regular mitochondria in the cell. >> >> >> >> >> --------------------------- Quote Link to comment Share on other sites More sharing options...
Guest guest Posted July 10, 1999 Report Share Posted July 10, 1999 But could the next step be looking at the DNA maybe? Re: DNA mutation >> Date: Wednesday, July 07, 1999 2:34 AM >> >> >> >> Kathy- >> >> Each cell has one nucleus which has the majority of our DNA. Half of it >comes from the mother and half >> from the father. Also in that cell are several to hundreds of >mitochondria. The mito have their own DNA >> which only comes from the mother. Some mito in this cell may be very >healthy, with no defects and some >> may be very sick, with major defects. >> >> I hope this helps. >> >> Laurie >> >> Hi, I am only on A right now and will surely be enlighted as I read on, >but >> >> > this came up today and between my 3 year old nephew visiting, my mom >> > diagnosed with return of breast cancer and my daughter , I had trouble >> > hearing my son's Dr. She was trying to give me this same >explanation.HOw >> > does nuclear mitochondria differ from regular mitochondria in the cell. >> >> >> >> >> --------------------------- Quote Link to comment Share on other sites More sharing options...
Guest guest Posted July 15, 1999 Report Share Posted July 15, 1999 I think the next step or preferred step is to look at the nuclear DNA. Kathy F ---------- > > To: Mitoonelist > Subject: Re: DNA mutation > Date: Saturday, July 10, 1999 2:02 PM > > > > But could the next step be looking at the DNA maybe? > > Re: DNA mutation > >> Date: Wednesday, July 07, 1999 2:34 AM > >> > >> > >> > >> Kathy- > >> > >> Each cell has one nucleus which has the majority of our DNA. Half of it > >comes from the mother and half > >> from the father. Also in that cell are several to hundreds of > >mitochondria. The mito have their own DNA > >> which only comes from the mother. Some mito in this cell may be very > >healthy, with no defects and some > >> may be very sick, with major defects. > >> > >> I hope this helps. > >> > >> Laurie > >> > >> Hi, I am only on A right now and will surely be enlighted as I read on, > >but > >> > >> > this came up today and between my 3 year old nephew visiting, my mom > >> > diagnosed with return of breast cancer and my daughter , I had trouble > >> > hearing my son's Dr. She was trying to give me this same > >explanation.HOw > >> > does nuclear mitochondria differ from regular mitochondria in the cell. > >> > >> > >> > >> > >> --------------------------- Quote Link to comment Share on other sites More sharing options...
Guest guest Posted July 15, 1999 Report Share Posted July 15, 1999 I think the next step or preferred step is to look at the nuclear DNA. Kathy F ---------- > > To: Mitoonelist > Subject: Re: DNA mutation > Date: Saturday, July 10, 1999 2:02 PM > > > > But could the next step be looking at the DNA maybe? > > Re: DNA mutation > >> Date: Wednesday, July 07, 1999 2:34 AM > >> > >> > >> > >> Kathy- > >> > >> Each cell has one nucleus which has the majority of our DNA. Half of it > >comes from the mother and half > >> from the father. Also in that cell are several to hundreds of > >mitochondria. The mito have their own DNA > >> which only comes from the mother. Some mito in this cell may be very > >healthy, with no defects and some > >> may be very sick, with major defects. > >> > >> I hope this helps. > >> > >> Laurie > >> > >> Hi, I am only on A right now and will surely be enlighted as I read on, > >but > >> > >> > this came up today and between my 3 year old nephew visiting, my mom > >> > diagnosed with return of breast cancer and my daughter , I had trouble > >> > hearing my son's Dr. She was trying to give me this same > >explanation.HOw > >> > does nuclear mitochondria differ from regular mitochondria in the cell. > >> > >> > >> > >> > >> --------------------------- Quote Link to comment Share on other sites More sharing options...
Guest guest Posted July 16, 1999 Report Share Posted July 16, 1999 In a message dated 99-07-06 13:24:35 EDT, you write: << Boo hoo...... Looks like I'll be spending alot of time at home this summer.... but how without services for Bart. Thx for listening. Kathy Foley >> Dear Kathy F.: I am so sorry to hear of your mother's cancer. As if you didn't have enough on your plate. My thoughts are with you... if that's OK. Lynnie Quote Link to comment Share on other sites More sharing options...
Guest guest Posted July 16, 1999 Report Share Posted July 16, 1999 In a message dated 99-07-06 13:24:35 EDT, you write: << Boo hoo...... Looks like I'll be spending alot of time at home this summer.... but how without services for Bart. Thx for listening. Kathy Foley >> Dear Kathy F.: I am so sorry to hear of your mother's cancer. As if you didn't have enough on your plate. My thoughts are with you... if that's OK. Lynnie Quote Link to comment Share on other sites More sharing options...
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