Re oral MgSo4

[Guest guest]

Thanks for a fine answer .

:

The only problem with that is that there seems to be a

signal that is generated by oral sulfate which tells the

kidneys to downregulate the reabsorption of sulfate by

actually changing the number of sulfate transporters that are

in the kidneys . Studies have shown that this downregulation

seems to lead to no net gain in sulfate systemically because

of how much more sulfate is spilled into the urine under this

condition. The levels used in these studies may have been

higher than what you state, and it has not been determined

WHAT hormone r other regulator signals this change, so we

don't know what the concentration has to be in the lumen or

inside of the gut to trigger this " dump sulfate " signal.

:

This study may have been done on people ( or rats ) that

had normal sulphate levels to begin with. Thus the body was

just adjusting correctly. If the study had been done on

people with low sulphate levels then things might be

different.

:

The intestines do need more sulfate than other organs, but

they need to get it from the basolateral side of cells. That

means the side of cells that faces the blood supply. This

means that the sulfate the cells needs is in the blood, and it

may be driven by some sort of concentration gradient,

making sulfate in the lumen of the gut interfere with sulfate

absorption from the blood.

:

This argument seems false to me because the reason the

gradient would be reduced would be because there was

sulphate in there. If the sulphate needed to be escorted

through into the blood then this would be a significant factor,

in that this transported sulphate might have to go to the liver

before it got into usable form.??

:

A study by Dr. Stipanuk at Cornell showed that in rats, to

accomodate the gut's need for sulfate, the liver exports

sulfate in large quantity into the blood, but all that sulfate

seems to be taken up out of the blood by the intestinal

system. So when blood levels of sulfate are low, it will

apparently be the gut that goes suffering.

:

Maybe the liver's regulation of sulphate is out ? How can

such a simple thing get so difficult ? I will still take the

epsom salts at 400 mg/litre and if I decide to stop then I will

cut down to 300, then 200, then 100, to give my body time

to readjust.

The sulphur article fuels the fire here in this group. There

seems to be some dispute as to what percentage of autistic

people have high cysteine levels. I don't know how, or if, this

can be determined.

Moses.