Guest guest Posted June 7, 1999 Report Share Posted June 7, 1999 In a message dated 99-06-06 07:50:16 EDT, you write: << When Dr. De Vivo said the mitochondria were already dysfunctional maybe that is what he meant. The mitochondria can't produce the energy required to deal with new changes in the body because they are working as best they can in their state and therefore that is when we see symptoms. Does this make any sense to you? . >> Dearest : You hit the nail on the head! Yup- you got just what I was trying to say. It makes perfect sense to me. I must add that I know some people with aquired amune deficiancy (AIDS) have also developed mitochondrial disease because the mito is undermined by the virus. Also mito. has occured when the system is going through AZT treatment, or so I have read. Lynnie Quote Link to comment Share on other sites More sharing options...
Guest guest Posted June 7, 1999 Report Share Posted June 7, 1999 Does anyone know how they see these ragged red fibers and are the at the end of nerve cells, or on muscle cells or what? One time in the hospital the nurse told me the ends of my nerves were actually ragged and I've always wondered what she was talking about or how she could have known that or was she talking ignorantly or what. S. Re: causes of mito > > >Lynnie, >I have also read about AZT treamtments. In the article I read it said some >people on AZT treatment will develop Ragged Red Fibers but they will >dissappear once the patient no longer takes AZT. The AZT must be affecting >the mitochondria and their function in some way but it doesn't seem to be >permanent. > > > >------------------------------------------------------------------------ >ONElist: the best source for group communications. >http://www.onelist.com >Join a new list today! >------------------------------------------------------------------------ >Brought to you by www.imdn.org - an on-line support group for those affected by mitochondrial disease. > Quote Link to comment Share on other sites More sharing options...
Guest guest Posted June 7, 1999 Report Share Posted June 7, 1999 Does anyone know how they see these ragged red fibers and are the at the end of nerve cells, or on muscle cells or what? One time in the hospital the nurse told me the ends of my nerves were actually ragged and I've always wondered what she was talking about or how she could have known that or was she talking ignorantly or what. S. Re: causes of mito > > >Lynnie, >I have also read about AZT treamtments. In the article I read it said some >people on AZT treatment will develop Ragged Red Fibers but they will >dissappear once the patient no longer takes AZT. The AZT must be affecting >the mitochondria and their function in some way but it doesn't seem to be >permanent. > > > >------------------------------------------------------------------------ >ONElist: the best source for group communications. >http://www.onelist.com >Join a new list today! >------------------------------------------------------------------------ >Brought to you by www.imdn.org - an on-line support group for those affected by mitochondrial disease. > Quote Link to comment Share on other sites More sharing options...
Guest guest Posted June 7, 1999 Report Share Posted June 7, 1999 , When a muscle biopsy is done, they can stain the tissue in a special way that will reveal " peripheral and inter myofibrillar accumulations of abnormal mitochondria " . I think the stain (a modified Gomori trichome stain) turns these areas red, and they have a ragged appearance. This is a common finding in MERRF and sometimes MELAS too. MERRF is a mitochondrial disease - myoclonic epilepsy and red ragged fibers. MELAS is a mitochondrial disease of mitochondrial encephalopathy, lactic acidosis and stroke. As far as having ragged nerves, that is just a saying that would mean the person was maybe a bit jumpy, very stressed out, and quite uptight. A situation we have all been in and happens often dealing with this illness! I don't think she meant you had anything physically or pathologically wrong with your nerves. Barbara mom to Alison/21/melas liver transplant due to Depakote toxicity A " n a message dated 6/7/99 11:46 Eastern Daylight Time, joelinda@... writes: > Does anyone know how they see these ragged red fibers and are the at the end > of nerve cells, or on muscle cells or what? One time in the hospital the > nurse told me the ends of my nerves were actually ragged and I've always > wondered what she was talking about or how she could have known that or was > she talking ignorantly or what. S. Quote Link to comment Share on other sites More sharing options...
Guest guest Posted June 7, 1999 Report Share Posted June 7, 1999 wrote: > Does anyone know how they see these ragged red fibers and are the at the end > of nerve cells, or on muscle cells or what? , Red Ragged fibers are seen in the muscle specimen when you have a biopsy. They can be seen in both frozen and fresh specimens and at one time, this was the only thing that they looked for to diagnose mitochondrial disease. The red ragged fibers are actually abnormal mitochondria that have died of and clumped making a red ragged appearance in the muscle. When there are abnormal mitochondria and they aren't doing their job effectively or efficiently, then the body sometimes tells them to produce more mitochondria to take over the work. This can be good or bad, if the mitochondria that are reproduced are sick then you end up with too many sick mitochondria choking out the healthy. This is called mitochondrial proliferation, which is also sometimes seen in a biopsy slide. When there are a lot of abnormal mitochondria and then go thru the normal process of dying off, or atopsis, then the remaining stuff that is left leaves the red ragged appearance. Jeannine Quote Link to comment Share on other sites More sharing options...
Guest guest Posted June 8, 1999 Report Share Posted June 8, 1999 Thanks Bob, the page was very helpful! The fibers don't really look like anything I was thinking of. I am having flashbacks to high school biology class , mom to Quote Link to comment Share on other sites More sharing options...
Guest guest Posted June 8, 1999 Report Share Posted June 8, 1999 Thank you Laurie. Re: causes of mito > > > S.- > >I'm thinking of you. > >Laurie > >> Everything is not OK and I will know more later, but I'm sure it will all >> work out fine in the end even if the end is eternity. The surgeon did tell >> me to get the primary Dr. working on figuring out some help for the hormonal >> issues as he couldn't believe I wasn't taking replacement hormones for the >> low adrenal function. Actually, I do but not prescription wise so will >> pursue that later. > > > > >------------------------------------------------------------------------ >How has ONElist changed your life? >Share your story with us at http://www.onelist.com >------------------------------------------------------------------------ >Brought to you by www.imdn.org - an on-line support group for those affected by mitochondrial disease. > Quote Link to comment Share on other sites More sharing options...
Guest guest Posted June 8, 1999 Report Share Posted June 8, 1999 Thank you Laurie. Re: causes of mito > > > S.- > >I'm thinking of you. > >Laurie > >> Everything is not OK and I will know more later, but I'm sure it will all >> work out fine in the end even if the end is eternity. The surgeon did tell >> me to get the primary Dr. working on figuring out some help for the hormonal >> issues as he couldn't believe I wasn't taking replacement hormones for the >> low adrenal function. Actually, I do but not prescription wise so will >> pursue that later. > > > > >------------------------------------------------------------------------ >How has ONElist changed your life? >Share your story with us at http://www.onelist.com >------------------------------------------------------------------------ >Brought to you by www.imdn.org - an on-line support group for those affected by mitochondrial disease. > Quote Link to comment Share on other sites More sharing options...
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