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10mCi RAI tracer dose???

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In your post dated 25 Jun 2001 you stated that you will receive

a 10 mCi tracer dose on 8 Aug. Didn't I read here that the

tracer dose should not be over 5 mCi???

Wondering in Ohio

()

----- Original Message -----

I have my 10mlc dose set up for Aug 8th, scan Aug 10th. I talked

to the nuclear meds guy today & he said I didn't have to follow

a LID. As long as I stayed away from Kelp & Sushi I should be

fine? I think I'll do the LID just to make sure my scan is

accurate!

Nov.3/00;lymph node removal, Nov.13/00;pap/thyca, TT..Dec.19/00;

2mlc.RAI, Dec.22/00;100mlc.RAI quarantine ... June

15/01;tg 0.5 ...

NOW GETTING READY FOR TRACER BODY SCAN Aug 10th/01!

__________________________________________________

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Geez!! Isn't medicine Black & White!!!! Why does there seem to be soooo

much Gray Area with every aspect of the treatment of this disease!!!!!

I thought it was weird too!!! My tracer at Christmas was only 2 or 3mlc?

Unfortunately I have to switch hospitals and can't go to the same place

I went for the first one because my Insurance has changed (grumble,

grumble!) So now I have to swallow a pill instead of the liquid I did

last time & last time the scan lasted only 20 minutes or so now this guy

says I'll be lying there for 50 minutes. This wouldn't seem so bad if I

didn't have " Claustrophobic Panic Attacks " , REAL BAD, when I am hypo!!!

Does anybody else know the maximum tracer dosage??????

thanks ...

Nov.3/00;lymph node removal, Nov.13/00;pap/thyca,TT .. Dec.19/00;

2mlc.RAI, Dec.22/00;100mlc.RAI quarantine ... June 15/01;tg 0.5 ... NOW

GETTING READY FOR TRACER BODY SCAN Aug 10th/01!

" donali... " wrote:

> --

> In your post dated 25 Jun 2001 you stated that you will receive

> a 10 mCi tracer dose on 8 Aug. Didn't I read here that the

> tracer dose should not be over 5 mCi???

> Wondering in Ohio

> ()

>

> ----- Original Message -----

>

> I have my 10mlc dose set up for Aug 8th, scan Aug 10th. I talked

> to the nuclear meds guy today & he said I didn't have to follow

> a LID. As long as I stayed away from Kelp & Sushi I should be

> fine? I think I'll do the LID just to make sure my scan is

> accurate!

>

> Nov.3/00;lymph node removal, Nov.13/00;pap/thyca, TT..Dec.19/00;

>

> 2mlc.RAI, Dec.22/00;100mlc.RAI quarantine ... June

> 15/01;tg 0.5 ...

> NOW GETTING READY FOR TRACER BODY SCAN Aug 10th/01!

>

> __________________________________________________

>

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You are right, 2-5mCi's is the more typical dose for scanning. 10mCi's

is generally considered an amount that would 'stun' the cells so they

would not take up additional RAI if an ablative dose is to be given soon

afterwards. There is a lot of literature available about this 'stunning

effect'.

I have scanned with 10mCi's several times (I had lung metastases and

they showed up better with the higher dose), but it had already been

determined that I would not be receiving an ablative dose after my

diagnostic scan. For those times, I went back on meds and had an

ablative dose months after that 10mCi diagnostic dose. So sometimes a

larger dose is used, but the patient doesn't usually receive an ablative

dose afterwards.

Marilyn

" donali... " wrote:

> --

> In your post dated 25 Jun 2001 you stated that you will receive

> a 10 mCi tracer dose on 8 Aug. Didn't I read here that the

> tracer dose should not be over 5 mCi???

> Wondering in Ohio

> ()

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, You can see which iodine isotope the hosp is using. See repost

***********************************************************************

(Dr. )

Date: Fri, 09 Jun 2000 07:39:24 -0400

Subject: Re: Iodine 123 -trial help

Sender: thyca-approval@...

To: thyca@...

Reply-to: thyca@...

Message-id:

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References: <v04210100b565531195ec@[61.12.22.121]>

<v04210101b565e2aa5d8e@[61.12.9.90]>

Kaaren,

The abililty to detect thyroid cancer depends in part on " image contrast " . Image

contrast is based on the amount of uptake in the " target " tissue (thyroid

cancer) relative to the amoung of radioactivity in the " background " (surrounding

non-thyroid tissue). You can have better image contrast by increasing the amount

of uptake in the thyroid cancer or decreasing the amount of radioactivitiy in

the background tissue. Most people excrete about 60% of a dose of radioiodine

(I-131 or I-123) over 24 hours and about 85% of a dose over 48 hours and 95% of

a dose over 72 hours. So about 40%, 15% and 5% are remain in the body at 24, 48

and 72 hours, respectively. That remaining amount contributes to background

radioactivity. So the best way to improve image contrast is to wait a longer

period of time for excretion of iodine unbound to thyroid cancer.

The problem with waiting longer is primarily radioactive decay. With I-131 this

is not much of a problem. I-131 has a half-life of 8 days so at the end of 3

days, just 23% of the administered radioactivity is lost due to physical decay.

With I-123 this is a much bigger problem. At the end of 24 hours, 73% of the

radioactivity is lost due to physical decay, at the end of 48 hours 94% of the

radioactivity is lost to decay and at 72 hours over 98% of the radioactivity is

lost to decay. So 72 hour imaging is not an option for I-123, unless we start

giving people 30 mCi of I-123 for imaging.

Again with I-131 we know that 72 hour images have better contrast than 24 hour

images and therefore can detect more thyroid cancer. I would expect the same to

be true with I-123 if one gave enough of a dose to overcome physical decay. This

has to be balanced against the fact that modern gamma camera images I-123 better

than I-131. To a modern gamma camera 1 mCi of I-123 in the body looks like 10

mCi of I-131. Will the improved images with I-123 outweigh the problem of having

to take images at 24 hours? This is a question that research must answer.

Stunning is injury to the thyroid from a scanning dose that prevents a

subsequent treatment dose from working. I monitor all of my patients for

stunning. It is an extremely rare problem when scanning dose are kept at 2.5 mCi

or less. Stunning only occurs because of the therapeutic effects of I-131. I-123

has no therapeutic radiation (beta radiation), so stunning should not occur with

I-123.

" mttws () " wrote:

> Geez!! Isn't medicine Black & White!!!! Why does there seem to be soooo

> much Gray Area with every aspect of the treatment of this disease!!!!!

> I thought it was weird too!!! My tracer at Christmas was only 2 or 3mlc?

> Unfortunately I have to switch hospitals and can't go to the same place

> I went for the first one because my Insurance has changed (grumble,

> grumble!) So now I have to swallow a pill instead of the liquid I did

> last time & last time the scan lasted only 20 minutes or so now this guy

> says I'll be lying there for 50 minutes. This wouldn't seem so bad if I

> didn't have " Claustrophobic Panic Attacks " , REAL BAD, when I am hypo!!!

>

> Does anybody else know the maximum tracer dosage??????

>

> thanks ...

>

>

> Nov.3/00;lymph node removal, Nov.13/00;pap/thyca,TT .. Dec.19/00;

> 2mlc.RAI, Dec.22/00;100mlc.RAI quarantine ... June 15/01;tg 0.5 ... NOW

> GETTING READY FOR TRACER BODY SCAN Aug 10th/01!

>

> " donali... " wrote:

>

> > --

> > In your post dated 25 Jun 2001 you stated that you will receive

> > a 10 mCi tracer dose on 8 Aug. Didn't I read here that the

> > tracer dose should not be over 5 mCi???

> > Wondering in Ohio

> > ()

> >

> > ----- Original Message -----

> >

> > I have my 10mlc dose set up for Aug 8th, scan Aug 10th. I talked

> > to the nuclear meds guy today & he said I didn't have to follow

> > a LID. As long as I stayed away from Kelp & Sushi I should be

> > fine? I think I'll do the LID just to make sure my scan is

> > accurate!

> >

> > Nov.3/00;lymph node removal, Nov.13/00;pap/thyca, TT..Dec.19/00;

> >

> > 2mlc.RAI, Dec.22/00;100mlc.RAI quarantine ... June

> > 15/01;tg 0.5 ...

> > NOW GETTING READY FOR TRACER BODY SCAN Aug 10th/01!

> >

> > __________________________________________________

> >

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