Re: correlation between all things (my longest post ever!)

[Guest guest]

Well, I have been meaning to getting around to studying flax seed, which is

not real easy to study. Anyhow, I found this great posting I thought I would

share concerning the cause of many diseases and how mercury is killing us:

Heidi N

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QUOTE===================================================

And most Yeasts proliferate in the presence of mercury, and altered pH (a

great debate!), which accompanies abnormal composition of bacterial flora - and

actually drives down the iron levels - because the yeasts have a way of not

using iron! Also, I found that historically, flax seed oil has been used to

remove mercury from the body, and this is where " you come in. "

When I got this far in my little investigation, I did a search for " mercury

flaxseed " and the following was at the top of the list! I made all of that

text blue, so you can keep track of what it says, and whatever I might add. You

can find this web page at http://www.talkinternational.com/science/als.htm

" Daily mercury exposures to those with _Amalgam_

(http://curezone.com/c/?http://curezone.com/faq/c.asp?a=3,76) dental fillings

commonly exceed the

Government health guideline for mercury, due to mercury's negative vapor

pressure

and galvanic action with other metals in the mouth(500). People also commonly

get exposures to mercury and other toxic metals such as lead, arsenic,

nickel, and aluminum from food, water, and other sources(501). All of these are

highly neurotoxic and are documented to cause neurological damage which can

result in chronic neurological conditions over time.

Mercury has been found to accumulate preferentially in the primary motor

function related areas involved in ALS- such as the brain stem, cerebellum,

rhombencephalon, dorsal root ganglia, and anterior horn motor neurons, which

enervate the skeletal muscles(48,291,327,329,442,500). Many studies of patients

with major neurological or degenerative diseases have found evidence amalgam

fillings play a major role in development of conditions such as such as ALS

(48,92,97,207,229b,325,416,423,442,468,470,35).

Here's what it does! A direct mechanism involving mercury's inhibition of

cellular enzymatic processes by binding with the hydroxyl radical(SH) in amino

acids appears to be the noticeable effects that pertain to a major part of

the connection to allergic/immune reactive conditions such as autism,

schizophrenia, eczema, psoriasis, and allergies(500), as well as to autoimmune

conditions such as ALS, Lupus, Alzheimer's(AD), Scleroderma, Chronic

Fatigue(CFS),

and Fibromyalgia(FM), etc . For example the patient has a lot of intestinal

distress with all types of milk products, simply because, mercury has been

found to strongly inhibit the activity of dipeptyl peptidase (DPP IV) which is

required in the digestion of the milk protein casein(411,412) as well as of

xanthine oxidase(439) Additional cellular level enzymatic effects of mercury's

binding with proteins include blockage of sulfur oxidation processes

(33,114,194,412), enzymatic processes involving vitamins B6 and B12(418),

effects on

the cytochrome-C energy processes (43,84,232,338c,35), along with mercury's

adverse effects on cellular mineral levels of calcium, magnesium, copper,zinc,

and lithium (43,96,119,198,333, 386,427,432,489,500). And along with these

blockages of cellular enzymatic processes, mercury has been found to cause

additional neurological and immune system effects in many through

immune/autoimmune reactions (60,313,314,375,405) A recent study gives a

comprehensive review

of studies finding a connection between ALS, toxic metals, and

autoimmunity(405).

Oxidative stress and reactive oxygen species(ROS) have been implicated as

major factors in neurological disorders including ALS, motor neuron

disease(MND), CFS, FM, Parkinson's(PD), Multiple Schlerosis(MS), and

Alzheimer's(AD)

(13,56,84,98,145,169,207b,424,442-444,453, 462,496). Mercury forms conjugates

with thiol compounds such as glutathione and cysteine and causes depletion of

glutathione, which is necessary to mitigate reactive damage. One study found

that insertion of amalgam fillings or nickel dental materials causes a

supression of the number of T-lympocytes(270), and impairs the T-4/T-8 ratio.

Low

T4/T8 ratio has been found to be a factor in autoimmune conditions. Mercury

induced lipid peroxidation has been found to be a major factor in mercury's

neurotoxicity, along with leading to decreased levels of glutathione

peroxidation and superoxide dismustase(SOD)(13,254,489,494-496).

Metalloprotein(MT) are

involved in metals transport and detoxification(114,442,464) What do you

think would happen if the MT's were all knocked out? Mercury inhibits sulfur

ligands in MT and in the case of intestinal cell membranes inactivates MT that

normally bind cuprous ions(477), thus allowing buildup of copper to toxic

levels in many and malfunction of the Zn/Cu SOD function. Exposure to mercury

results in changes in metalloprotein compounds that have genetic effects,

having

both structural and catalytic effects on gene _expression

(114,241,296,442,464,477,495). Some of the processes affected by such MT

control of genes

include cellular respiration, metabolism, enzymatic processes, metal-specific

homeostasis, and adrenal stress response systems. Significant physiological

changes occur when metal ion concentrations exceed threshold levels. Such MT

formation also appears to have a relation to autoimmune reactions in

significant

numbers of people (114,60,313, 342,369,442,464). Of a population of over 3000

tested by the immune lymphocyte reactivity test(MELISA,60,275), 22% tested

positive for inorganic mercury and 8% for methyl mercury, but much higher

percentages tested positive for autoimmune condition patients. In the MELISA

laboratory, 12 out of 13 ALS patients tested showed positive immune reactivity

lymphocyte responses to metals in vitro [87], indicating metals reactivity a

likely major factor in their condition. A recent study assessed the possible

causes of high ALS rates in Guam and similar areas and the recent decline in

this

conditions. One of the studies conclusions was that a likely major factor

for the high ALS rates in Guam and similar areas in the past was chronic

dietary deficiency since birth in Ca, Mg and Zn induced excessive absorption of

divalent metal cations such as mercury which accelerates oxidant-mediated

neuronal degenerations in a genetically susceptible population(466).

Mercury blocks the immune function of magnesium and zinc (198,427,43,38),

(And what effect to you think that might produce?) whose deficiencies are known

to cause significant neurological effects(461,463,430). The low Zn levels

result in deficient CuZnSuperoxide dismustase (CuZnSOD), which in turn leads to

increased levels of superoxide due to toxic metal exposure. This is in

addition to mercury's effect on metallothionein and copper homeostasis as

previously discussed(477). Copper is an essential trace metal which plays a

fundamental role in the biochemistry of the nervous system(489,495463,,464).

Several

chronic neurological conditions involving copper metabolic disorders are well

documented like 's Disease and Menkes Disease. Mutations in the

copper/zinc enzyme superoxide dismustase(SOD) have been shown to be a major

factor

in the motor neuron degeneration in conditions like familial ALS. Exposures to

toxic metals such as mercury and cadmium have been found to cause such

effects, and similar effects on Cu/Zn SOD have been found to be a factor in

other

conditions such as autism, Alzheimer's, Parkinson's, and non-familial ALS

(489,495,464,469,111). This condition can result in zinc deficient SOD and

oxidative damage involving nitric oxide, peroxynitrite, and lipid

peroxidation(495,496,489), which have been found to affect glutamate mediated

excitability

and apoptosis of nerve cells and effects on mitochondria (495,496,119) These

effects can be reduced by zinc supplementation(464,495,430), as well as

supplementation with antioxidants and nitric oxide-suppressing agents and

peroxynitrite scavengers such as Vit C, Vit E, lipoic acid, Coenzyme Q10,

carnosine,

gingko biloba, N-acetylcysteine, etc.(444,464,494,495,469,470). Ceruloplasmin

in plasma can be similarly affected by copper metabolism disfunction, like SOD

function, and is often a factor in neurodegeneration(489).

Calcium plays a major role in the extreme neurotoxicity of mercury and

methyl mercury. Both inhibit cellular calcium ATPase and calcium uptake by

brain

microsomes at very low levels of exposure (270,288,329,333,432,56,). Protein

Kinase C (PKC) regulates intracellular and extra cellular signals across

neuronal membranes, and both forms of mercury inhibit PKC at micromolar levels,

as

well as inhibiting phorbal ester binding(43,432). They also block or inhibit

calcium L-channel currents in the brain in an irreversable and concentration

dependent manner. Mecury vapor or inorganic mercury exposure affects the

posterior cingulate cortex and causes major neurological effects with

sufficient

exposure(428,453). Some of the resulting conditions include stomatitis,

tremor, ADD, erythism, etc. Metallic mercury is much more potent than methyl

mercury in such actions, with 50 % inhibitation in animal studies at 13

ppb(333,329).

Mercury exposure also degrades the immune system resulting in more

susceptability to viral, bacterial, or parasitic effects along with candida

albicans

which are often present in those with chronic conditions and require treatment

(404,468,470,485,500). Four such commonly found in ALS patients are

mycoplasma AND echo-7 enterovirus(468,470), candida albicans(404), and

parasites(485). Mercury from amalgam interferes with production of cytokines

that activate

macrophage and neutraphils, disabling early control of viruses or other

pathogens and leading to enhanced infection(131,251).

Spatial and temporal changes in intracellular calcium concentrations are

critical for controlling gene _expression and neurotransmitter release in

neurons(432,438). Mercury alters calcium homeostasis and calcium levles in the

brain and affects gene _expression and neurotransmitter release through its

effects on calcium, etc. Mercury inhibits sodium and potassium (N,K)ATPase in

dose

dependent manner and inhibits dopamine and noreprenephrine uptake by

synaptosomes and nerve implulse transfer(288,270,56,43,35). Mercury also

interrupts

the cytochrome oxidase system, blocking the ATP energy function (35,43,84),

chronic flatigue syndrom, lowering immune growth factor IGF-I levels and

impairing astrocyte function(119,131). Astrocytes are common cells in the CNS

involved in the feeding and detox of nerve cells. Increases in inflamatory

cytokines such as caused by toxic metals trigger increased free radical

activity

and damage to astrocyte and astrocyte function(152). IGF-I protects against

brain and neuronal pathologies like ALS, MS, and Fibromyalgia by protecting the

astrocytes from this destructive process.

Mercury lymphocyte reactivity and effects on glutamate in the CNS induce

_CFS_ (http://curezone.com/c/?http://curezone.com/faq/c.asp?a=4,111,676) type

symptoms including profound tiredness, musculoskeletal pain, sleep

disturbances, gastrointestinal and neurological problems along with other CFS

symptoms

and Fibromyalgia(342,346,369,375,496). Mercury has been found to be a common

cause of Fibromyalgia(293,346,369) , which based on a Swedish survey occurs in

about 12% of women over 35 and 5.5% of men(368). Glutamate is the most

abundant amino acid in the body and in the CNS acts as excitory neurotransmitter

(346,386,412,496,119), which also causes inflow of calcium. Astrocytes, a type

of cell in the brain and CNS with the task of keeping clean the area around

nerve cells, have a function of neutralizing excess glutamate by transforming

it to glutamic acid. If astrocytes are not able to rapidly neutralize excess

glutamate, most obviously because of the mercury's influence, then a buildup

of glutamate and calcium occurs, causing swelling and neurotoxic

effects(119,131,152,333,496). Mercury and other toxic metals inhibit astrocyte

function

in the brain and CNS(119,131), causing increased glutamate and calcium

related neurotoxicity(119,152,333,226a,496) which are responsible for much of

the

Fibromyalgia symptoms and a factor in neural degeneration in MS and ALS. This

is also a factor in conditions such as CFS, Parkinson's, and

ALS(346,416,496). Animal studies have confirmed that increased levels of

glutamate(or

aspartate, another amino acid excitory neurotransmitter) cause increased

sensitivity

to pain , as well as higher body temperature- both found in

CFS/Fibromyalgia. Mercury and increased glutamate activate free radical forming

processes

like xanthine oxidase which produce oxygen radicals and oxidative neurological

damage(346,142,13). Medical studies and doctors treating Fibromyalgia have

found that supplements which cause a decrease in glutamate or protect against

its effects have a positive effect on Fibromyalgia and other chronic neurologic

conditions. Some that have been found to be effective include CoQ10 (444),

ginkgo biloba and pycnogenol(494a), NAC(54,494a), Vit B6, methyl

cobalamine(B12), L-carnitine, choline, ginseng, vitamins C and E, nicotine, and

omega 3

fatty acids(fish and flaxseed oil) (417,495e).

Another neurological effect of mercury that occurs at very low levels is

inhibition of nerve growth factors, for which deficiencies result in nerve

degeneration. Only a few micrograms of mercury severely disturb cellular

function

and inhibits nerve growth (175,147,226,255,305,149). Prenatal or neonatal

exposures have been found to have life long effects on nerve function and

susceptability to toxic effects. Prenatal mercury vapor expsoure that results

in

levels of only 4 parts per billion in newborn rat brains was found to cause

decreases in nerve growth factor and other effects(305). This is a level that

is

common in the population with several amalgam fillings or other

exposures(500). Insulin-like-growth factor I (IGF-I) are positively correlated

with

growth hormone levels and have been found to be the best easily measured marker

for levels of growth hormone, but males have been found more responsive to this

factor than women(497). IGF-I controls the survival of spinal motor neruons

affected in ALS during development as well as later in life(497,498). IGF-I

and insulin levels have been found to be reduced in ALS pateients with

evidence this is a factor in ALS(497,498). Several clinical trials have found

IGF-I

treatment is effective at reducing the damage and slowing the progression of

ALS and Alzheimer's with no medically important adverse effects(498). It has

also been found that in chronically ill patients the levels of pituitary and

thyroid hormones that control many bodily processes are low, and that

supplenting both thyrotropin-releasing hormone and growth control hormone is

more

effective at increasing all of these hormone levels in the patient(499).

Tick-borne encephalitis, such as Lyme Diseaese, has been found to cause ALS

in a significant portion of untreated acute cases(471). Lyme disease is

widespread in the U.S.

Large numbers of patients diagnosed with ALS have been found to have

treatable tick-borne encephaltis, and many have recovered after treatment.

Extremely toxic anerobic bacteria from _root canals_

(http://curezone.com/c/?http://curezone.com/dental/root_canal.asp) or

cavitations formed at

incompletely healed tooth extraction sites have also been found to be common

factors

in fibromyalgia and other chronic neurological conditions such as

Parkinson's and ALS, with condensing osteitis which must be removed with a

surgical

burr along with 1 mm of bone around it(35,437,500). Have you had any teeth

extracted in the last year or so? Cavitations have been found in 80% of sites

from

wisdom tooth extractions tested and 50% of molar extraction sites

tested(35,437). The incidence is likely somewhat less in the general

population.

Medical studies and doctors treating fibromylagia have found that supplements

which

cause a decrease in glutamate or protect against its effects have a positive

effect on fibromyalgia and other chronic neurologic conditions like ALS.

Some that have been found to be effective include Vit B6, methyl

cobalamine(B12), L-carnitine, choline, ginseng, Ginkgo biloba,vitamins C and E,

CoQ10,

nicotine, and omega 3 fatty acids(fish and flaxseed oil) (417,468).

Clinical tests of patients with ALS, MND, Parkinson's, Alzheimer's,

Lupus(SLE), and rheumatoid arthritis have found that the patients generally

have

elevated plasma cysteine to sulphate ratios, with the average being 500% higher

than controls(330,331,56,84), and in general being poor sulphur oxidizers.

This means that these patients have blocked enzymatic processes for converting

the basic cellular fuel cysteine to sulfates and glutathione, and thus

insufficient sulfates available to carry out necessary bodily processes.

Mercury has

been shown to diminish and block sulphur oxidation and thus reducing

glutathione levels which is the part of this process involved in detoxifying

and

excretion of toxics like mercury(33). Glutathione is produced through the

sulphur oxidation side of this process. Low levels of available glutathione

have

been shown to increase mercury retention and increase toxic effects(111), while

high levels of free cysteine have been demonstrated to make toxicity due to

inorganic mercury more severe(333,194,56,33e). The deficiency in conjugation

and detoxification of sulfur based toxins in the liver results in toxic

metabolites and progressive nerve damage over time (331). Mercury has also been

found to play a part in inducing intolerance and neuronal problems through

blockage of the P-450 enzymatic process(84,33e). Patients with some of these

conditions have found that bathing in _Epsom Salts_

(http://curezone.com/c/?http://curezone.com/forums/m.asp?f=73 & i=116) (magnesium

sulfate) offers temporary

relief for some of their symptoms by providing sulfates that avoid the

blocked metabolic pathway. A test that some doctors treating conditions like

ALS

usually prescribe to measure the cysteine to sulfate ratio and other

information useful in diagnosis and treatment is the Great Smokies Diagnostic

Labs

comprehensive liver detox test(386). The test results come with some

recommendations for treatment. A hair test for toxic metals is also usually

ordered to

determine toxic exposures that might be involved(386). A more definitive test

such as MELISA for immune reactivity to toxics is available by sending blood

to a European lab(87). Other labs also have other useful tests such as Immune

Reactivity Biocompatability Tests(445), ELISA or organic acid panels or amino

acid panels(386). Treatment using IV glutathione, vitaminC, and minerals has

been found to be very effective in the stabilizing and ammelioration of some

of these chronic neurological conditions by neurologist such as Perlmutter

in Florida(469).

In one subtype of ALS, damaged, blocked, or faulty enzymatic superoxide

dimutase (SOD) processes appear to be a major factor in cell apoptosis involved

in the codition(443). Mercury is known to damage or inhibit SOD

actitivity(441,33,111).

Total dental revision(TDR) which includes replacing amalgam fillings,

extracting root canaled teeth, and treating cavitations has been found to offer

significant health improvements to many with ALS and other autoimmune

conditions(35,293,437). Root canals and cavitations have been found to harbor

anerobic

bacteria which give off toxins of extreme toxicity which block enzymatic

processes at the cellular level causing degenerative processes according to the

medical labs that do the tests(437,35), similar to mercury's effects but in

some cases even more toxic . IGF-1 treatments have also been found to

alleviate some of the symptoms of ALS(424). Medical studies and doctors

treating

fibromylagia have found that supplements which cause a decrease in glutamate or

protect against its effects have a positive effect on fibromyalgia. Some that

have been found to be effective in treating metals related autoimmune

conditions include Vit B6, CoenzymeQ10, methyl cobalamine(B12), L-carnitine,

choline, ginseng, Ginkgo biloba, vitamins C and E, nicotine, and omega 3 fatty

acids(fish and flaxseed oil) (417,444,468).

One dentist with severe symptoms similar to ALS improved after treatment for

mercury poisoning(246), and others treated for mercury poisoning or using

TDR have also recovered or significantly improved

(97,229,423,405,406,468-470,485,35).The Edelson Clinic in Atlanta which treats

ALS patients reports

similar experience(406), and the Perlmutter Clinic has also had success with

treatment of ALS and other degenerative neurological coditions(469).

While there are many studies documenting effectiveness of chemical chelators

like DMSA and DMPS at reducing metals levels and alleviating adverse effects

for most conditions, and many thousands of clinical case results(500,501);

there is also some evidence from animal studies that these chelators can

result in higher levels of mercury in the motor neurons in the short term which

might be a problem for ALS patients(). Thus other detox options might be

preferable for ALS patients until enough clinical evidence is available

treating

ALS patients with them with mercury toxicity. Another chelator used for clogged

arteries, EDTA, forms toxic compounds with mercury and can damage brain

function(307). Use of EDTA may need to be restricted in those with high Hg

levels. N-acetylcysteine(NAC) has been found to be effective at increasing

cellular

glutathione levels and chelating mercury(54). Experienced doctors have also

found additional zinc to be useful when chelating mercury(222) as well as

counteracting mercury's oxidative damage(43). Zinc induces metallothionein

which

protects against oxidative damage and increases protective enzyme activities

and glutathione which tend to inhibit lipid peroxidation and suppress

mercury toxicity(430,464). Also lipoic acid,LA, has been found to dramatically

increase excretion of inorganic mercury(over 12 fold), but to cause decreased

excretion of organic mercury(494d) and copper. Lipoic acid has a protective

effect regarding lead or inorganic mercury toxicity through its antioxidant

properties(494), but should not be used with high copper until copper levels

are

reduced. LA and NAC (N-acetylcysteine) also increase glutathione levels and

protect against superoxide radical/ peroxynitrite damage, so thus have an

additional neuroprotective effect(494ab,54). Zinc is a mercury and copper

antagonist and can be used to lower copper levels and protect against mercury

damage.

Lipoic acid has been found to have protective effects against cerebral

ischemic-reperfusion, excitotoxic amino acid(glutamate) brain injury,

mitochondrial dysfunction, diabetic neuropathy(494). Other antioxidants such as

carnosine(495a), Coenzyme Q10,Vitamins C & E, gingko biloba, and pycnogenol

have also

been found protective against degenerative neurological conditions(494,495e,

444).

________________________

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