1st Cycle-DMSA Only

[Guest guest]

Thank you for your post. I am anxious to hear others experiences as we will

begin our first round the first weekend in September. I will keep you posted

on what it's like for us.

-Phyllis

[ ] 1st Cycle-DMSA Only

> Hi Folks,

> Just wanted to let everyone know our experience with our first cycle of

DMSA

> only. is 8 years old (almost 9) weighing about 55 lbs. Because we

> couldn't get hold of Dr. Holmes to discuss the 4 hr protocol vs. the 8 hr

> protocol, we went ahead and did what she prescribed which is 3 days on/11

> days off, 200 mg DMSA & 500 mg glycine every 8 hours. I braced myself for

> the worst. On the first day (Friday), he was the most calm I've seen him

in

> a long time (he is usually quite hyperactive). His language was great and

> frequent. Day 2 (Saturday) was much the same although towards the end of

the

> day he became a bit frustrated a couple of times (nothing long lasting).

Day

> 3 (Sunday, today) he is a mad man! No one in the house can say a thing

> without him flying off the handle. He is so very frustrated. It is very

odd

> to watch. One minute he is fine, the next he is screaming at the top of

his

> lungs. It just goes back and forth.

>

> That's our experience at the beginning of this long treatment, and I just

> wanted to share the experience with you all in hopes that it will be

helpful

> to someone.

>

> Yours,

> Mickey

>

>

>

[Guest guest]

> > Hi Folks,

> > Just wanted to let everyone know our experience with our first

cycle of

> DMSA

> > only. is 8 years old (almost 9) weighing about 55 lbs.

Because we

> > couldn't get hold of Dr. Holmes to discuss the 4 hr protocol vs.

the 8 hr

> > protocol, we went ahead and did what she prescribed which is 3

days on/11

> > days off, 200 mg DMSA & 500 mg glycine every 8 hours. I braced

myself for

> > the worst. On the first day (Friday), he was the most calm I've

seen him

> in

> > a long time (he is usually quite hyperactive). His language was

great and

> > frequent. Day 2 (Saturday) was much the same although towards the

end of

> the

> > day he became a bit frustrated a couple of times (nothing long

lasting).

> Day

> > 3 (Sunday, today) he is a mad man! No one in the house can say a

thing

> > without him flying off the handle. He is so very frustrated. It

is very

> odd

> > to watch. One minute he is fine, the next he is screaming at the

top of

> his

> > lungs. It just goes back and forth.

> >

> > That's our experience at the beginning of this long treatment, and

I just

> > wanted to share the experience with you all in hopes that it will

be

> helpful

> > to someone.

Now that you have experienced every 8 hour dosing, why not just try

every 4 hours next time and see what that is like? Flip back and

forth a few times if you need to - the side effects of each are pretty

reproducible.

Andy

> >

> > Yours,

> > Mickey

> >

> >

> >

[Guest guest]

Andy

I have been thinking that the 4 hour protocol was based upon the lifetime of

ALA in the blood. Here, Mickey is using DMSA only. Does DMSA also have the

same pharacokinetics as ALA or am I missing something?

Ken

[ ] Re: 1st Cycle-DMSA Only

> > > Hi Folks,

> > > Just wanted to let everyone know our experience with our first

> cycle of

> > DMSA

> > > only. is 8 years old (almost 9) weighing about 55 lbs.

..

>

> Now that you have experienced every 8 hour dosing, why not just try

> every 4 hours next time and see what that is like? Flip back and

> forth a few times if you need to - the side effects of each are pretty

> reproducible.

>

> Andy

> > >

> > > Yours,

> > > Mickey

=======================================================

>

[Guest guest]

Dear Ken,

I'm not Andy, but I have his opinion on this down pat.

(He seems to be a bit scarce on the list right now---

apparently busy elsewhere.)

Andy's advice on how often chelators are needed is:

ALA: every 3 hours

DMSA: every 4 hours

DMPS: every 8 hours.

More often is okay, less often is not okay.

When taking ALA and DMSA together, take them

every 3 hours -- the shorter of the 2 times.

All of it is based on the blood level thing--- same

premise in all cases.

The 4 hours is DEFINATELY about DMSA.

The 4 hours is based on DMSA NOT ALA. ALA is every 3.

Although Andy says it is okay to take ALA every 4 at

night if that helps, but to go back to 3 during day.

(I've been taking it after 3.5 hours of sleep, which

works well for me--- I'm generally awake after 7 hrs

of sleep-- so this is one nighttime awakening at

3.5 hours, then another pill 7 hours after I went to

sleep.)

I hope that is some help in spite of my not being Andy

best,

Moria

At 08:13 AM 8/13/2001 -0700, you wrote:

>Andy

>I have been thinking that the 4 hour protocol was based upon the lifetime of

>ALA in the blood. Here, Mickey is using DMSA only. Does DMSA also have the

>same pharacokinetics as ALA or am I missing something?

>

>Ken

[Guest guest]

In reply to my post, Andy wrote:

<Now that you have experienced every 8 hour dosing, why not just try every 4

hours next time and see what that is like? Flip back & forth a few times if

you need to - the side effects of each are pretty reproducible.>

Andy,

I most definitely would like to do that. Again, my son is 8 years old and

weighs around 55 lbs. If I understand you correctly, we should give him 25

mg of DMSA every 4 hours.

One other thing: Today is our first " off " day following 3 days of chelation

with 200 mg DMSA every 8 hours. While his behavior during most of the

chelation time was good (Day 3 was filled with drastic mood swings), today he

is doing a lot of attention-seeking behaviors that we haven't seen in quite a

while. Behaviors such as throwing things and then running off, dumping water

on the floor, knocking over things - laughing after each behavior. It seems

to come in bursts. Also, lots of verbal stimming. Again, we haven't seen

these behaviors in a long time. Would you attribute these behaviors to the

chelation process? If so, could you explain what is happening inside his

little body? Thank you so much - you are so very much appreciated!

Yours,

Mickey