Amazing science

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Hi, there is another group on Yahoo that deals with helminthic therapy as its'

subject, we

have a high proportion of members who have MS and are experiencing very good

early

results. Our groups has only been active for a few months.

Helminthic therapy is like probiotics in principal, but utilizes helminths not

bacteria.

Here is the abstract of a great paper, there are others at " helminthictherapy "

here on

Yahoo that use animal models to get the same astonishing results. That and the

full paper

from this abstract is available there in the files area:

http://groups.yahoo.com/group/helminthictherapy

Please pay us a visit if you are interested in leading edge science about MS,

Crohn's

disease, Asthma, Sjorgren's, RA, Lupus. This science, and it is hard science, is

simply

amazing.

Objective: To assess whether parasite infection is correlated with a reduced

number of

exacerbations and altered immune reactivity in multiple sclerosis (MS).

Methods: A prospective, double-cohort study was performed to assess the clinical

course

and radiological findings in 12 MS patients presenting associated eosinophilia.

All

patients presented parasitic infections with positive stool specimens. In all

parasite-

infected MS patients, the eosinophilia was not present during the 2 previous

years.

Eosinophil counts were monitored at 3- to 6-month intervals. When counts became

elevated, patients were enrolled in the study. Interleukin (IL)-4, IL-10, IL-12,

transforming growth factor (TGF)- & #1113098;, and interferon- & #1113097;

production by myelin basic protein

specific peripheral blood mononu- clear cells were studied using enzyme-linked

immunospot (ELISPOT). FoxP3 and Smad7 expression were studied by reverse-

transcriptase polymerase chain reaction.

Results: During a 4.6-year follow-up period, parasite-infected MS patients

showed a

significantly lower number of exacerbations, minimal variation in disability

scores, as well

as fewer magnetic resonance imaging changes when compared with uninfected MS

patients. Furthermore, myelin basic protein–specific responses in peripheral

blood showed

a significant increase in IL-10 and TGF- & #1113098; and a decrease in IL-12 and

interferon- & #1113097;–

secreting cells in infected MS patients compared with noninfected patients.

Myelin basic

protein–specific T cells cloned from infected subjects were characterized by the

absence of

IL-2 and IL-4 production, but high IL-10 and/or TGF- & #1113098; secretion,

showing a cytokine

profile similar to the T-cell subsets Tr1 and Th3. Moreover, cloning frequency

of

CD4 & #1113090;CD25 & #1113090; FoxP3 & #1113090; T cells was substantially increased

in infected patients compared

with uninfected MS subjects. Finally, Smad7 messenger RNA was not detected in T

cells

from infected MS patients secreting TGF- & #1113098;. Interpretation: Increased

production of IL-10

and TGF- & #1113098;, together with induction of CD25 & #1113090;CD4 & #1113090;

FoxP3 & #1113090; T cells, suggests that

regulatory T cells induced during parasite infections can alter the course of

MS.

Ann Neurol 2007;61:97–108