Zometa

[Guest guest]

Has anyone tried Zometa and if yes how have you responded to it.. My husband was on Zometa for a month and now we are about to try another medication as it did nit do much for his PSA level.. thanksVito Del Re' wrote: glad to hear your good news my surgery was 5-22 and incontinence has been nothin but a nightmare vito brooklyn Ready for the edge of your seat? Check out tonight's top picks on Yahoo! TV.

Park yourself in front of a world of choices in alternative vehicles.Visit the Yahoo! Auto Green Center.

[Guest guest]

My husband has been on Zometa since March. He was prescribed the

Zometa due to the cancer spreading to his bones. It is supposed to help

with the pain & bone complications.

Zoladex, though, is sometimes used in hormone therapy. I was thinking

you might be referring to this drug. My husband has no experience with

this drug.

My husband started taking Casodex and injections of Lupron for his PSA

level in December 2006 when he was diagnosed (PSA 417 with mets to the

bones). This treatment lowered his PSA to 11 by February. But, he

stopped this treatment in June because the PSA started to rise & the

cancer became hormone refractory. August 8th will be his first chemo

treatment.

Take Care,

>

> Has anyone tried Zometa and if yes how have you responded to it.. My

husband was on Zometa for a month and now we are about to try another

medication as it did nit do much for his PSA level..

>

> thanks

>

[Guest guest]

“…we are about

to try another medication as it did nit do much for his PSA level..”

Zometa won’t do anything for his PSA. From the manufactures

website:

ZOMETA is a treatment for patients

with prostate cancer that has spread to the bones. It may reduce or delay bone

fractures or pressure on the spinal cord that can result from bone damage from

advanced prostate cancer. ZOMETA can also help patients who already have

experienced bone complications. ZOMETA is not chemotherapy and may be used with

other cancer treatments‚ such as radiation‚ hormonal therapy‚

or chemotherapy.

Emerson

www.flhw.org

From: ProstateCancerSupport [mailto:ProstateCancerSupport ] On Behalf Of

Sent: Friday, August 03, 2007 7:44

PM

To: ProstateCancerSupport

Subject: Re:

Zometa

Has anyone tried Zometa and if yes how have you responded to it..

My husband was on Zometa for a month and now we are about to try another

medication as it did nit do much for his PSA level..

thanks

Vito Del Re'

<bklynboro> wrote:

glad to hear your good news my surgery was 5-22

and incontinence has been nothin but a nightmare

vito

brooklyn

Ready for the edge of your seat? Check out

tonight's top picks on Yahoo! TV.

 

Park yourself in front of a world of choices in alternative vehicles.

Visit

the Yahoo! Auto Green Center.

[Guest guest]

My husbands Cancer has spread to the bones too.. he has been on Zometa for three months now and we are about to switch drugs as they discovered that his PSA level has risen. He has been experiencing alot of pain and has a fever almost every night which clears by morning.. Tamara

Yahoo! oneSearch: Finally, mobile search that gives answers, not web links.

[Guest guest]

What other drugs is he on besides Zometa?

Again, Zometa does not treat the PSA or

the cancer, it is a bone strengthener only.

Emerson

www.flhw.org

From: ProstateCancerSupport [mailto:ProstateCancerSupport ] On Behalf Of

Sent: Saturday, August 04, 2007

9:00 PM

To: ProstateCancerSupport

Subject: Re:

Re: Zometa

My husbands Cancer has spread to the bones too.. he has been on Zometa

for three months now and we are about to switch drugs as they discovered that

his PSA level has risen.

He has been experiencing alot of pain and has a fever almost

every night which clears by morning..

Tamara

 

Yahoo! oneSearch: Finally, mobile

search that gives answers, not web links.

[Guest guest]

Anyone reading this site have someone close or themselves who are presently taking Zometa infusions? What is this doing etc. if being used.

My Uro at this weeks discussion advised that I should start this procedure because of my condition with metatises to bone and presently having ADT implant.

Have set up to start this procedure Tuesday. Blood tested says I am ok to go ahead.

Are there any serious answers to questions about using this procedure that I could have overlooked from the mfgs print out and the insistence of the Urologist?

Thanx.

Bill.

76... Gleason 8 stage 4... metastises to spine... Radiation of spine end May 25th 2007.

[Guest guest]

Bill,

The main reason for using Zometa (zoledronic acid) is to help with the potential

problem of osteoporosis, which can be a major side effect of ADT (Androgen

Deprivation Therapy).

The procedures that I have

seen are that at the commencement of the ADT treatment, bone density is

measured and if there is evidence of a wasting of the bone, Zometa is started.

Metatasis is not always associated with bone wastage, but it may be in your

case that this is what is happening. I am sure your oncologist will be able to

show you the te4st results.

If you Google Zometa side

effects you will find several sitr4es. This is an extract from one – it is

important to bear in mind that not everyone who has used Zometa has experienced

these side effects.:

<snip> Zoledronic

acid is generally well tolerated and the side effects are similar to those seen

with pamidronate. Some patients may experience mild and transient side effects,

such as fever, flu-like symptoms, fatigue, gastrointestinal effects, or anemia,

which may be related to their underlying disease. Although rare, long-term use

of the drug at higher doses or zoledronic acid infused in less than 15 minutes

can affect the kidneys. For this reason, patients who receive zoledronic acid

should have serum creatinine assessed prior to each treatment. In addition,

serum calcium, electrolytes, phosphate, magnesium, and hematocrit/hemoglobin

should also be monitored regularly.

Upon treatment initiation,

dosage adjustments are recommended in myeloma patients with mild or moderate

kidney impairment. Treatment with zoledronic acid is not recommended in

patients with severe kidney impairment because studies in this patient population

have not been conducted. In myeloma, the risk of kidney dysfunction may be

increased when it is used in combination with thalidomide or drugs known to

affect kidney function (ie, nonsteroidal antiinflammatory drugs). There are

animal data to suggest there can be a problem when bisphosphonates are

administered during pregnancy. Therefore, zoledronic acid should not be used

during pregnancy unless a physician feels the benefits outweigh the risks. "

In the first paragraph it

notes that side effects are similar to those experienced with

Aredia/pamidronate. When checking out pamidronate side effects the term

" skeletal pain " was included along with the same side effects as

noted above for Zometa/zoledronic acid, so maybe this was erroneously left out

in the above paragraph.

All the best,

Terry Herbert in Melbourne, Australia

Diagnosed ‘96: Age 54: Stage T2b: PSA 7.2: Gleason

3+3=6: No treatment. Jun '07 PSA 42.0 - Bony Metastasis:Starting ADT.

My site is at www.yananow.net

As a

physician, I am painfully aware that most of the decisions we make with regard

to prostate cancer are made with inadequate data: Dr

“Snuffy” Myers.

From:

ProstateCancerSupport [mailto:ProstateCancerSupport ]

On Behalf Of Rita and Bill

Sent: Saturday, 1 September 2007

1:24 PM

To: ProstateCancerSupport

Subject:

Zometa

Anyone reading this site have someone close or themselves

who are presently taking Zometa infusions? What is this doing etc.

if being used.

My Uro at this weeks discussion advised that I should start

this procedure because of my condition with metatises to bone and

presently having ADT implant.

Have set up to start this procedure Tuesday. Blood

tested says I am ok to go ahead.

Are there any serious answers to questions about using this

procedure that I could have overlooked from the mfgs print out and the

insistence of the Urologist?

Thanx.

Bill.

76... Gleason 8 stage 4... metastises to spine...

Radiation of spine end May 25th 2007.

[Guest guest]

Terry

Thanx for your quick reply. Your very informative information given of what Zometa is and what it is administered for will be, I am sure, a benefit to any out there that may have advanced PCa and etc. who are using Zometa or contemplating to do so.

I had looked up the google and did note the side effects as you described.

When asking about Zometa,I did want to hear from someone who has been on that regime to see if there was anything more they may have experienced ( good or bad) other than what is given by the mfg. and the google.

So far you were the first to reply. I am still hoping to hear from any user if they care to respond further? I believe once started, it will be administered every month as long as you are above the grass? Or when and if you cannot tolerate it?

(And I do have a poor dictionary as it is surely 'metastasis' not metastisis and then to a progressed 'metastases'. I need a better pc....damn thing! I am just not willing to take the blame for my garble and printing mistakes! Please forgive... then ignore.)

Again Sir, thanx a whole...xxxxxx....

Bill.

Zometa

Anyone reading this site have someone close or themselves who are presently taking Zometa infusions? What is this doing etc. if being used.

My Uro at this weeks discussion advised that I should start this procedure because of my condition with metatises to bone and presently having ADT implant.

Have set up to start this procedure Tuesday. Blood tested says I am ok to go ahead.

Are there any serious answers to questions about using this procedure that I could have overlooked from the mfgs print out and the insistence of the Urologist?

Thanx.

Bill.

76... Gleason 8 stage 4... metastises to spine... Radiation of spine end May 25th 2007.

[Guest guest]

Terry

Thanx for your quick reply. Your very informative information given of what Zometa is and what it is administered for will be, I am sure, a benefit to any out there that may have advanced PCa and etc. who are using Zometa or contemplating to do so.

I had looked up the google and did note the side effects as you described.

When asking about Zometa,I did want to hear from someone who has been on that regime to see if there was anything more they may have experienced ( good or bad) other than what is given by the mfg. and the google.

So far you were the first to reply. I am still hoping to hear from any user if they care to respond further? I believe once started, it will be administered every month as long as you are above the grass? Or when and if you cannot tolerate it?

(And I do have a poor dictionary as it is surely 'metastasis' not metastisis and then to a progressed 'metastases'. I need a better pc....damn thing! I am just not willing to take the blame for my garble and printing mistakes! Please forgive... then ignore.)

Again Sir, thanx a whole...xxxxxx....

Bill.

Zometa

Anyone reading this site have someone close or themselves who are presently taking Zometa infusions? What is this doing etc. if being used.

My Uro at this weeks discussion advised that I should start this procedure because of my condition with metatises to bone and presently having ADT implant.

Have set up to start this procedure Tuesday. Blood tested says I am ok to go ahead.

Are there any serious answers to questions about using this procedure that I could have overlooked from the mfgs print out and the insistence of the Urologist?

Thanx.

Bill.

76... Gleason 8 stage 4... metastises to spine... Radiation of spine end May 25th 2007.

[Guest guest]

Hi Bill.

As I remember the cautions on Zometa the first dose should be lower, 1 to 2 mg and make sure it is infused over a longer than 15 minute time in order to avoid "Acute phase response."

Go to this URL and search on APR.

http://prostate-cancer.org/index.html

Hope this helps.

"il faut d'abord durer." Hemingway

Zometa

Anyone reading this site have someone close or themselves who are presently taking Zometa infusions? What is this doing etc. if being used.

My Uro at this weeks discussion advised that I should start this procedure because of my condition with metatises to bone and presently having ADT implant.

Have set up to start this procedure Tuesday. Blood tested says I am ok to go ahead.

Are there any serious answers to questions about using this procedure that I could have overlooked from the mfgs print out and the insistence of the Urologist?

Thanx.

Bill.

76... Gleason 8 stage 4... metastises to spine... Radiation of spine end May 25th 2007.

[Guest guest]

Bill,

I was on Zometa

two years ago when I had chemotherapy; I think that I had six infusions; I was only

troubled by the first one. I had flu like symptoms for about 18 hours, and was

perfectly OK on subsequent infusions. After my chemo finished, I was put

on to ibanronic acid (Bandronate), which is supposed to do the same thing as Zometa,

but by mouth, much more convenient.

Terry is

right in what he said about it primarily being used for osteoporosis, but, and it was a big but for me, is the

fact that many oncologists use it to delay the progress of further metastases.

I was certainly put on it for slowing the progress of the disease, not for osteoporosis.

I never had a bone density test. When I had a bone scan about a year after

Zometa there had been no further progress in my bones.

However

there is always a price to pay. There is a slight risk of getting

something called ONJ (osteo- necrosis of the jaw). It is now suggested that if you

need any dental work done; it is done before commencing Zometa. The

risk is slight, but it can go on for many years after stopping Zometa. It is

very troublesome if you get it. I am prepared to take that risk, as I

have now gone back on to Zometa, because my last bone scan was absolutely

horrible, the metastases had progressed all over the place. Perhaps

ibandronic acid is not as good as Zometa; perhaps it is the disease progressing

despite everything. Who knows?

I looked up

what Dr (Snuffy) Myers had to say about Zometa back in Sept 2004. He

said “I’ve noticed in my own patients that the progress of bone

involvement in this disease now seems to be much slower”. He does go on to

give all the warnings about ONJ. In his article he said that he had seen 700 Pca

patients, among them were 3 who had ONJ associated with Zometa.

But

remember that was back in 2004 and figures may well be very different now.

Best of

luck with your decision.

Regards,

Ward

North

Wales

From:

ProstateCancerSupport [mailto:ProstateCancerSupport ]

On Behalf Of Rita and Bill

Sent: 01 September 2007 04:24

To: ProstateCancerSupport

Subject:

Zometa

Anyone reading this site have someone close or themselves

who are presently taking Zometa infusions? What is this doing etc.

if being used.

My Uro at this weeks discussion advised that I should start

this procedure because of my condition with metatises to bone and

presently having ADT implant.

Have set up to start this procedure Tuesday. Blood

tested says I am ok to go ahead.

Are there any serious answers to questions about using this

procedure that I could have overlooked from the mfgs print out and the

insistence of the Urologist?

Thanx.

Bill.

76... Gleason 8 stage 4... metastises to spine...

Radiation of spine end May 25th 2007.

[Guest guest]

Hi

So very good of you to tell us all about your doing Zometa. (Chemo..gad.. I can only imagine)

It is always a big problem with me that when one is asked by the Docs if you have any questions concerning certain procedures one is always left guessing. Probably because many like myself being no where congnizant of what the whole thing is about, usually do not get acceptable personal answers or pose the right questions.

Your adventure is certainly grist for the mill and I dearly appreciate your sharing this with us. I had already turned this down once as suggested by the Urologist and again there is some apprehension going in this coming week to start the procedure. The oncologist has never mentioned doing Zometa, but then I am still not far enough out from the radiation done to my spine last May for him to ascertain what that did as he will test in November about that result and what is happening to the rest of my bones.

Your information has allayed some of my misgiving and I am better prepared for what may or may not be in the cards for me or for anyone else for that matter who are contemplating doing Zometa. I will certainly monitor the results and particularly with regards to my jaw, as no one has suggested or looked in my mouth to determine dental problems that I am sure I have. Dental wasn't discussed, though from what I have read saying a full dental exam is necessary before beginning this procedure lends me to question the urgency of my Urologist to begin procedure without that exam. This needs a follow up.

Thank you........

my wife insists I proceed, so there ya go.

Bill.

Zometa

Anyone reading this site have someone close or themselves who are presently taking Zometa infusions? What is this doing etc. if being used.

My Uro at this weeks discussion advised that I should start this procedure because of my condition with metatises to bone and presently having ADT implant.

Have set up to start this procedure Tuesday. Blood tested says I am ok to go ahead.

Are there any serious answers to questions about using this procedure that I could have overlooked from the mfgs print out and the insistence of the Urologist?

Thanx.

Bill.

76... Gleason 8 stage 4... metastises to spine... Radiation of spine end May 25th 2007.