Jump to content
RemedySpot.com

Neurotransmitter changes in dementia with Lewy bodies and Parkinson disease deme

Rate this topic


Guest guest

Recommended Posts

Guest guest

Neurotransmitter changes in dementia with Lewy bodies and Parkinson disease

dementia in vivo.

2/24/10

OBJECTIVE: Although Parkinson disease with dementia (PDD) and dementia with Lewy

bodies (DLB) show a wide clinical and neuropathologic overlap, they are

differentiated according to the order and latency of cognitive and motor symptom

appearance. Whether both are distinct disease entities is an ongoing

controversy. Therefore, we directly compared patients with DLB and PDD with

multitracer PET.

METHODS: PET with (18)fluorodopa (FDOPA), N-(11)C-methyl-4-piperidyl acetate

(MP4A), and (18)fluorodeoxyglucose (FDG) was performed in 8 patients with PDD, 6

patients with DLB, and 9 patients with PD without dementia vs age-matched

controls. Data were analyzed with voxel-based statistical parametric mapping and

region of interest-based statistics.

RESULTS: We found a reduced FDOPA uptake in the striatum and in limbic and

associative prefrontal areas in all patient groups. Patients with PDD and

patients with DLB showed a severe MP4A and FDG binding reduction in the

neocortex with increasing signal diminution from frontal to occipital regions.

Significant differences between PDD and DLB were not found in any of the

radioligands used. Patients with PD without dementia had a mild cholinergic

deficit and no FDG reductions vs controls.

CONCLUSIONS: Patients with dementia with Lewy bodies and Parkinson disease

dementia share the same dopaminergic and cholinergic deficit profile in the

brain and seem to represent 2 sides of the same coin in a continuum of Lewy body

diseases. Cholinergic deficits seem to be crucial for the development of

dementia in addition to motor symptoms. The spatial congruence of cholinergic

deficits and energy hypometabolism argues for cortical deafferentation due to

the degeneration of projection fibers from the basal forebrain.

http://tinyurl.com/y88fenu

Link to comment
Share on other sites

Join the conversation

You are posting as a guest. If you have an account, sign in now to post with your account.
Note: Your post will require moderator approval before it will be visible.

Guest
Reply to this topic...

×   Pasted as rich text.   Paste as plain text instead

  Only 75 emoji are allowed.

×   Your link has been automatically embedded.   Display as a link instead

×   Your previous content has been restored.   Clear editor

×   You cannot paste images directly. Upload or insert images from URL.

Loading...
×
×
  • Create New...