Incidental Lewy body disease: Clinical comparison to a control cohort

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Incidental Lewy body disease: Clinical comparison to a control cohort

3/5/2010

Abstract

Limited clinical information has been published on cases pathologically

diagnosed with incidental Lewy body disease (ILBD). Standardized, longitudinal

movement and cognitive data was collected on a cohort of subjects enrolled in

the Sun Health Research Institute Brain and Body Donation Program. Of 277

autopsied subjects who had antemortem clinical evaluations within the previous 3

years, 76 did not have Parkinson's disease, a related disorder, or dementia of

which 15 (20%) had ILBD. Minor extrapyramidal signs were common in subjects with

and without ILBD. Cognitive testing revealed an abnormality in the ILBD group in

the Trails B test only. ILBD cases had olfactory dysfunction; however, sample

size was very small. This preliminary report revealed ILBD cases have movement

and cognitive findings that for the most part were not out of proportion to

similarly assessed and age-similar cases without Lewy bodies. Larger sample size

is needed to have the power to better assess group differences.

http://www3.interscience.wiley.com/journal/123295838/abstract