Re: Blood pressure - rampiril

[Guest guest]

Barry,

Ideally you want your BP to be lower than 132/85. I have never had the dry

cough personally, but I would mention it to your doctor to see if there is an

alternate drug you can take.

Yes, to answer your question, Ace Inhibitors are known to have a renal

protective measure. I don't know what your doctor means by saying they are

hard on your kidneys.

Pierre is our resident expert on BP meds, so I will let him elaborate on this

one.

[Guest guest]

Barry,

I've noticed if I drink a huge glass of water my dry cough doesn't seem to be

so bad. When it gets really bad I've also tried throat drops-1 a day and

those seem to help as well.

Cy,

when they took your son off Lisinopril did they put him on another drug to

control bp?

Thanks,

Dana

In a message dated 3/26/03 1:44:45 PM Central Standard Time,

cyashleywebb@... writes:

<< Hi Barry,

I noticed that my son's creatinine began edging up after he was on

lisinopril (an ace inhibitor). Am happy to report that the creatinine went

right back down after discontinueing the drug (for other unrelated reasons).

In my son's case, the doc explained that the creatinine increase was " for

the greater good " , given the renal protective effective effect of ace

inhibitors. The doc also explained that the creatinine increase might have

been caused by the fact that the kidney were no longer " hyperfiltrating " (in

my son's case, he started cyclosporine at the same time, which brought the

protein under control). In truth, I didn't quite follow the

hyperfiltrating argument.

We didn't have the cough so I cannot speak to that..

Cy >>

[Guest guest]

Hi Cy,

Thanks for answering my question. 17.5 mg-wow!

I hope your son is doing better now with all the med changes! I can't

believe I'm saying this, but I can't wait to go back to the neph on Tuesday!

Dana

In a message dated 3/26/03 4:29:30 PM Central Standard Time,

cyashleywebb@... writes:

<< Hi Dana,

In February, was sick (bad cold). They ran a CBC on him at that time

and determined he was a little anemic. Did a ret count (reticulocyte) to

determine if the anemia was due to hemolysis (possibly caused by virus, or

other autoimmune process) or a matter of bone marrow suppression (possibly

caused by the kidney disease, diet or lisinopril). We discontinued the

lisinopril, which (four weeks later) they've begun to realize didn't have

anything to do with the anemia. Much to my chagrin, (this is a very

long-winded way of answering your question), they didn't put him on another

BP drug (they talked about putting him on clonidine (sp?). We've been

through big drug changes the past month - discontinueing cyclosporin,

starting IV pred + cellcept. - and I guess they were reluctant to make one

more drug change. Yesterday, we finally got the OK to add 2.5 mg of

lisinopril to the daily meds (we were originally on 17.5 mg!).

Cy >>

[Guest guest]

Hi Barry,

I noticed that my son's creatinine began edging up after he was on

lisinopril (an ace inhibitor). Am happy to report that the creatinine went

right back down after discontinueing the drug (for other unrelated reasons).

In my son's case, the doc explained that the creatinine increase was " for

the greater good " , given the renal protective effective effect of ace

inhibitors. The doc also explained that the creatinine increase might have

been caused by the fact that the kidney were no longer " hyperfiltrating " (in

my son's case, he started cyclosporine at the same time, which brought the

protein under control). In truth, I didn't quite follow the

hyperfiltrating argument.

We didn't have the cough so I cannot speak to that..

Cy

Blood pressure - rampiril

> Hi Everyone

>

> I currently been put on rampiril just gone from 7.5mg to 10 mg for my

> blood pressure which is average 132/85 which I think is high but my

> GP is not too concearned but thinks the ACE inhibutor May be putting

> my kidneys under strain !!!!!!!!!(117 to 122 creatine clearance level

> I thought the idea of these pills was to do the opposite!! I look

> forward to any comments about this .

>

> ps Has anyone else that takes this ACE inhibutor found a way to

> control that dry cough. I changed from Morning to night taking which

> resulted in a break for 2 weeks with no coughing !!! But My body has

> got wise to it .

>

> Thanks

>

> Barry

>

>

>

> To edit your settings for the group, go to our Yahoo Group

> home page:

> http://groups.yahoo.com/group/iga-nephropathy/

> Visit our companion website at www.igan.ca. The site is entirely supported

by donations. If you would like to help, go to:

> http://www.igan.ca/id62.htm

>

> Thank you

>

>

[Guest guest]

Hi Barry.

1) If you get the ACE inhibitor cough, there isn't much you can do about it

except switch to something else. Your doctor should be familiar with this

problem, since it's very common. Sometimes, rarely, another ACE inhibitor

might do, but usually the whole class of drugs will cause it. An angiotensin

II receptor blocker (Cozaar, for example), if often the next drug to try.

2) When you lower blood pressure, less blood goes through the kidneys during

a given period, so glomerular filtration goes down a bit (that's kidney

function). ACE inhibitors in particular do that because they lower the blood

pressure within the filters of the kidneys, more than other drugs. Cozaar

and its like do the same. There is no real loss of kidney function. There

are rare people whose kidney function may drop more than 30%. When that

happen, you have to change drugs.

Pierre

Blood pressure - rampiril

> Hi Everyone

>

> I currently been put on rampiril just gone from 7.5mg to 10 mg for my

> blood pressure which is average 132/85 which I think is high but my

> GP is not too concearned but thinks the ACE inhibutor May be putting

> my kidneys under strain !!!!!!!!!(117 to 122 creatine clearance level

> I thought the idea of these pills was to do the opposite!! I look

> forward to any comments about this .

>

> ps Has anyone else that takes this ACE inhibutor found a way to

> control that dry cough. I changed from Morning to night taking which

> resulted in a break for 2 weeks with no coughing !!! But My body has

> got wise to it .

>

> Thanks

>

> Barry

>

>

>

> To edit your settings for the group, go to our Yahoo Group

> home page:

> http://groups.yahoo.com/group/iga-nephropathy/

> Visit our companion website at www.igan.ca. The site is entirely supported

by donations. If you would like to help, go to:

> http://www.igan.ca/id62.htm

>

> Thank you

>

>

[Guest guest]

Barry:

I wouldn't wait one more minute if I were you. I had this reaction

from an Ace Inihibitor, and it was caught while I was in the

hospital by a Med student. They switched me to Avapro (an ARB II),

and my cough was gone the next day.

The bruised diaphragm and the sore throat lasted another 4 weeks. I

love Avapro -- there are hardly any side effects, and it appears to

have helped my progression greatly.

I would call your doctor today!

Walt

[Guest guest]

The ACEI cough can become a vicious cycle. I got to the point that I

actually traumatized my vocal chords.

I had a boss a few years ago who was on enalapril for high blood pressure.

That's one of the ACE inhibitors. He used to proclaim that it never affected

him at all, but he didn't realize he was sort of half-coughing and clearing

his throat all the time.

Pierre

Re: Blood pressure - rampiril

>

> Thanks Walt

> ihatefleet wrote:Barry:

>

> I wouldn't wait one more minute if I were you. I had this reaction

> from an Ace Inihibitor, and it was caught while I was in the

> hospital by a Med student. They switched me to Avapro (an ARB II),

> and my cough was gone the next day.

>

> The bruised diaphragm and the sore throat lasted another 4 weeks. I

> love Avapro -- there are hardly any side effects, and it appears to

> have helped my progression greatly.

>

> I would call your doctor today!

>

> Walt

[Guest guest]

Hi Dana,

In February, was sick (bad cold). They ran a CBC on him at that time

and determined he was a little anemic. Did a ret count (reticulocyte) to

determine if the anemia was due to hemolysis (possibly caused by virus, or

other autoimmune process) or a matter of bone marrow suppression (possibly

caused by the kidney disease, diet or lisinopril). We discontinued the

lisinopril, which (four weeks later) they've begun to realize didn't have

anything to do with the anemia. Much to my chagrin, (this is a very

long-winded way of answering your question), they didn't put him on another

BP drug (they talked about putting him on clonidine (sp?). We've been

through big drug changes the past month - discontinueing cyclosporin,

starting IV pred + cellcept. - and I guess they were reluctant to make one

more drug change. Yesterday, we finally got the OK to add 2.5 mg of

lisinopril to the daily meds (we were originally on 17.5 mg!).

Cy

Re: Blood pressure - rampiril

> Barry,

> I've noticed if I drink a huge glass of water my dry cough doesn't seem to

be

> so bad. When it gets really bad I've also tried throat drops-1 a day and

> those seem to help as well.

> Cy,

> when they took your son off Lisinopril did they put him on another drug to

> control bp?

> Thanks,

> Dana

>

> In a message dated 3/26/03 1:44:45 PM Central Standard Time,

> cyashleywebb@... writes:

>

> << Hi Barry,

> I noticed that my son's creatinine began edging up after he was on

> lisinopril (an ace inhibitor). Am happy to report that the creatinine

went

> right back down after discontinueing the drug (for other unrelated

reasons).

> In my son's case, the doc explained that the creatinine increase was " for

> the greater good " , given the renal protective effective effect of ace

> inhibitors. The doc also explained that the creatinine increase might

have

> been caused by the fact that the kidney were no longer " hyperfiltrating "

(in

> my son's case, he started cyclosporine at the same time, which brought

the

> protein under control). In truth, I didn't quite follow the

> hyperfiltrating argument.

> We didn't have the cough so I cannot speak to that..

> Cy >>

>

>

> To edit your settings for the group, go to our Yahoo Group

> home page:

> http://groups.yahoo.com/group/iga-nephropathy/

> Visit our companion website at www.igan.ca. The site is entirely supported

by donations. If you would like to help, go to:

> http://www.igan.ca/id62.htm

>

> Thank you

>

>

[Guest guest]

I coughed my head off- finally had to switch to an ARB. I get much less

fatigue with the ARB but do have to pay more at the pharmacy.

[Guest guest]

Don't you just love the way that doctors say things like that????? (in regards

to the ACE inhibitors). In October of last year, when I became unwell and was

hospitalised, my creatinine had shot up to almost 200, and the doctor

temporarily took me off my ACE inhibitors for that reason too!!

(????????????????). I got into a huge argument with him over it, but he wouldn't

change his mind on it.

baz321 wrote:Hi Everyone

I currently been put on rampiril just gone from 7.5mg to 10 mg for my

blood pressure which is average 132/85 which I think is high but my

GP is not too concearned but thinks the ACE inhibutor May be putting

my kidneys under strain !!!!!!!!!(117 to 122 creatine clearance level

I thought the idea of these pills was to do the opposite!! I look

forward to any comments about this .

ps Has anyone else that takes this ACE inhibutor found a way to

control that dry cough. I changed from Morning to night taking which

resulted in a break for 2 weeks with no coughing !!! But My body has

got wise to it .

Thanks

Barry

[Guest guest]

Talking of water, as you all probably know, I'm another suffering from the

dreaded fatigue, but I have found if I'm getting a really bad wave of it, a

pint of water helps just a little.

Sally. UK

Re: Blood pressure - rampiril

Barry,

I've noticed if I drink a huge glass of water my dry cough doesn't seem to

be

so bad. When it gets really bad I've also tried throat drops-1 a day and

those seem to help as well.

Cy,

when they took your son off Lisinopril did they put him on another drug to

control bp?

Thanks,

Dana

In a message dated 3/26/03 1:44:45 PM Central Standard Time,

cyashleywebb@... writes:

<< Hi Barry,

I noticed that my son's creatinine began edging up after he was on

lisinopril (an ace inhibitor). Am happy to report that the creatinine

went

right back down after discontinueing the drug (for other unrelated

reasons).

In my son's case, the doc explained that the creatinine increase was " for

the greater good " , given the renal protective effective effect of ace

inhibitors. The doc also explained that the creatinine increase might

have

been caused by the fact that the kidney were no longer " hyperfiltrating "

(in

my son's case, he started cyclosporine at the same time, which brought the

protein under control). In truth, I didn't quite follow the

hyperfiltrating argument.

We didn't have the cough so I cannot speak to that..

Cy >>