Re: Fwd: Immunosciences Lab: Autoimmune Diseases

[Guest guest]

Lea,

I been reading and just wondered why? You have to destroy all your hard work. I missed that part.

Donna

[Guest guest]

Lea,

I am so sorry I didn't understand why, I must have missed that post. That is awful, I just wonder if the judge was sick from implants, if they would react this way? It is sad that we all have to do our own Research anyway, struggle daily to find a doctor who will take you seriously. I still have not found one doctor, other than Dr. Kolb, to take me serious. I am exhausted and to the point of giving up really. It is sad Lea that all your Research had to be destroyed, I will never understand why a judge would order that????

Donna

[Guest guest]

Dearest Rogene:

Thank you for posting this information and for the "contact". I still have folders that will not be deleted, but some of the hard copies have been destroyed. It hurts to help me to destroy all of my hard work, but we have no choice. This was not about money, I just knew too much in an Oil Rich province.

Love you honey...Lea

~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~``

Fwd: Immunosciences Lab: Autoimmune Diseases

Autoimmune DiseasesPage 1 of 2

Autoimmunity, in which the immune system recognizes and attacks the self's own tissue, is not as simple as it seems. Self-recognition appears to be at the heart of health as well as of certain diseases.

It is generally assumed that the main job of the immune system is to distinguish between what is "self" and what is "not self". Once the distinction has been made, "self" is pre-served and "not self" is destroyed. At the most general level, of course, this is true, and human beings remain alive and healthy only because it is so. Recently it has become clear, however, that at a finer level of detail the distinction between self and other is not absolute. One of the paths to this insight has been provided by the autoimmune disorders, in which the immune system attacks normal, healthy tissue. Autoimmune disease, which may be crippling or fatal, can strike any tissue or organ. Its victims are often in the prime of life, and for unknown reasons they are more frequently women than men.

Research work on a form of autoimmune arthritis shows that the basis of autoimmunity may be a resemblance between a specific foreign molecule and a molecule of the self. This finding is consistent with a model of the immune system in which the immune system receptors that perform the work of recognition can themselves be recognized by other receptors. Such "self-recognition," which was strictly outlawed by older models of the immune sys-tem, may form the basis of a network whose equilibrium keeps the body healthy. When it is disrupted, as it is in autoimmunity, disease results.

This new picture, in which self and world are no longer absolutely distinct, has already begun to yield practical benefits in the form of vaccines that may ultimately ease the substantial suffering caused by autoimmune diseases. The list of autoimmune diseases is both long and disturbing. It includes multiple sclerosis, in which the tissue attacked is myelin (a sub-stance that sheathes nerves in the central nervous system); myasthenia gravis, in which the target is a receptor molecule for the important neurotransmitter acetylcholine; rheumatoid arthritis, whose target is the peripheral joint; type I (juvenile) diabetes mellitus, in which the cells producing insulin are destroyed, and systemic lupus erythematosus, in which DNA, blood vessels, skin and kidneys are attacked. In contrast to AIDS, which is marked by an in activation of key cells in the immune system, in all these diseases the immunological response is strong and well focused; it is, however, directed at some essential component of the body. These immunological attacks are detected in clinical laboratory by the measurement of tissue-specific and tissue non-specific antibodies.

Autoimmune DiseasesPage 2 of 2

Autoimmune diseases can be separated broadly into two categories. One group is characterized by the presence of auto antibodies which are broadly reactive with nuclear or cytoplasmic antigens and do not demonstrate any tissue specificity. Included in this group are diseases such as rheumatoid arthritis, SLE, mixed connective tissue disease, scleroderma, Sjogren’s syndrome, and dermatomyositis/polymyositis. A second group of autoimmune diseases is characterized by autoantibodies which demonstrate tissue specificity. These diseases include thyroiditis, chronic liver diseases (including primary biliary cirrhosis and chronic active Hepatitis), certain cases of pernicious anemia, and myasthenia gravis.

The autoantibodies which appear in these disease states demonstrate different degrees of specificity with respect to both tissue and species. Tissue-specific autoantibodies include those which react against erythrocyte stromalantigens, platelets, antihemophilic globulin, thyroid tissue and other tissues, and g-globulin (rheumatoid factor). Autoantibodies without tissue specificity include anti-nuclear, anti-nucleoprotien, anti-DNA, and anti-cytoplasmicantibodies. Autoantibodies directed against the formed elements of the blood can undoubtedly induce disease by causing the destruction and removal of these cells from the circulation. However, it is far less certain whether other types of autoantibodies play pathogenic roles.

Most studies of autoantibodies in both humans and animals have concentrated on the reactivity of humoral constituents. However, it should be remembered that the cell-mediated immune response is far more efficient in terms of tissue destruction. Since humoral antibodies have been shown, under appropriate circumstances, to prevent cell-mediated tissue damage, it is conceivable that they may have a protective rather than a destructive function. There is presently no indication whether the autoantibodies detected in human disease rep-resent a primary manifestation of the disease itself or a secondary event stimulated by an underlying, but unrelated, abnormality. In ether event, the mechanisms which may be responsible for the abrogation of natural immunologic tolerance are worthy of consideration. Four general mechanisms have been proposed in the pathogenesis of autoantibody production:1.alterations in the structure or distribution of antigens;2.formation of cross-reactive antibodies following exposure to extrinsic antigens;3.release of sequestered antigens; and4.abnormalities of immunologic responsive-ness.

An assault on the self through molecular mimicry or antigenic similarity between foreign antigens (virus, bacreria) and human tissue antigens which may end with an autoimmune disease is presented in Fig. 8. This process which may strike many target tissues is shown in Table 1.

[Guest guest]

Lea

When I moved to a smaller home, I mailed all my research (thousands

of articles) to Kathy K. ston in Missouri, so it would be in good

hands to use for our cause.

I spent days and days and hours and hours in a Medical Library

searching out articles, probably when I was too sick to care if it

killed me. The copy fluid made me ill, so I would have to wait a

couple of weeks and then go back. But I had thousands of articles on

silicone, so KKJ has them now.

Maybe you could give them to someone instead of destroying them.

Lynda

At 08:34 AM 11/7/2006, you wrote:

>Dearest Rogene:

>

>Thank you for posting this information and for the " contact " . I

>still have folders that will not be deleted, but some of the hard

>copies have been destroyed. It hurts to help me to destroy all

>of my hard work, but we have no choice. This was not about money, I

>just knew too much in an Oil Rich province.

>

>Love you honey...Lea

>~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~``

> Fwd: Immunosciences Lab: Autoimmune Diseases

>

>

>

>

>Autoimmune Diseases

>Page 1 of 2

>

>Autoimmunity, in which the immune system recognizes and attacks the

>self's own tissue, is not as simple as it seems. Self-recognition

>appears to be at the heart of health as well as of certain diseases.

> It is generally assumed that the main job of the immune system is

> to distinguish between what is " self " and what is " not self " . Once

> the distinction has been made, " self " is pre-served and " not self "

> is destroyed. At the most general level, of course, this is true,

> and human beings remain alive and healthy only because it is so.

> Recently it has become clear, however, that at a finer level of

> detail the distinction between self and other is not absolute. One

> of the paths to this insight has been provided by the autoimmune

> disorders, in which the immune system attacks normal, healthy

> tissue. Autoimmune disease, which may be crippling or fatal, can

> strike any tissue or organ. Its victims are often in the prime of

> life, and for unknown reasons they are more frequently women than men.

>Research work on a form of autoimmune arthritis shows that the basis

>of autoimmunity may be a resemblance between a specific foreign

>molecule and a molecule of the self. This finding is consistent with

>a model of the immune system in which the immune system receptors

>that perform the work of recognition can themselves be recognized by

>other receptors. Such " self-recognition, " which was strictly

>outlawed by older models of the immune sys-tem, may form the basis

>of a network whose equilibrium keeps the body healthy. When it is

>disrupted, as it is in autoimmunity, disease results.

>This new picture, in which self and world are no longer absolutely

>distinct, has already begun to yield practical benefits in the form

>of vaccines that may ultimately ease the substantial suffering

>caused by autoimmune diseases. The list of autoimmune diseases is

>both long and disturbing. It includes multiple sclerosis, in which

>the tissue attacked is myelin (a sub-stance that sheathes nerves in

>the central nervous system); myasthenia gravis, in which the target

>is a receptor molecule for the important neurotransmitter

>acetylcholine; rheumatoid arthritis, whose target is the peripheral

>joint; type I (juvenile) diabetes mellitus, in which the cells

>producing insulin are destroyed, and systemic lupus erythematosus,

>in which DNA, blood vessels, skin and kidneys are attacked. In

>contrast to AIDS, which is marked by an in activation of key cells

>in the immune system, in all these diseases the immunological

>response is strong and well focused; it is, however, directed at

>some essential component of the body. These immunological attacks

>are detected in clinical laboratory by the measurement of

>tissue-specific and tissue non-specific antibodies.

>

>Autoimmune Diseases

>Page 2 of 2

>

>Autoimmune diseases can be separated broadly into two categories.

>One group is characterized by the presence of auto antibodies which

>are broadly reactive with nuclear or cytoplasmic antigens and do not

>demonstrate any tissue specificity. Included in this group are

>diseases such as rheumatoid arthritis, SLE, mixed connective tissue

>disease, scleroderma, Sjogren's syndrome, and

>dermatomyositis/polymyositis. A second group of autoimmune diseases

>is characterized by autoantibodies which demonstrate tissue

>specificity. These diseases include thyroiditis, chronic liver

>diseases (including primary biliary cirrhosis and chronic active

>Hepatitis), certain cases of pernicious anemia, and myasthenia gravis.

>The autoantibodies which appear in these disease states demonstrate

>different degrees of specificity with respect to both tissue and

>species. Tissue-specific autoantibodies include those which react

>against erythrocyte stromalantigens, platelets, antihemophilic

>globulin, thyroid tissue and other tissues, and g-globulin

>(rheumatoid factor). Autoantibodies without tissue specificity

>include anti-nuclear, anti-nucleoprotien, anti-DNA, and

>anti-cytoplasmicantibodies. Autoantibodies directed against the

>formed elements of the blood can undoubtedly induce disease by

>causing the destruction and removal of these cells from the

>circulation. However, it is far less certain whether other types of

>autoantibodies play pathogenic roles.

>Most studies of autoantibodies in both humans and animals have

>concentrated on the reactivity of humoral constituents. However, it

>should be remembered that the cell-mediated immune response is far

>more efficient in terms of tissue destruction. Since humoral

>antibodies have been shown, under appropriate circumstances, to

>prevent cell-mediated tissue damage, it is conceivable that they may

>have a protective rather than a destructive function. There is

>presently no indication whether the autoantibodies detected in human

>disease rep-resent a primary manifestation of the disease itself or

>a secondary event stimulated by an underlying, but unrelated,

>abnormality. In ether event, the mechanisms which may be responsible

>for the abrogation of natural immunologic tolerance are worthy of

>consideration. Four general mechanisms have been proposed in the

>pathogenesis of autoantibody production:1.alterations in the

>structure or distribution of antigens;2.formation of cross-reactive

>antibodies following exposure to extrinsic antigens;3.release of

>sequestered antigens; and4.abnormalities of immunologic responsive-ness.

>An assault on the self through molecular mimicry or antigenic

>similarity between foreign antigens (virus, bacreria) and human

>tissue antigens which may end with an autoimmune disease is

>presented in <http://www.immuno-sci-lab.com/2003_cat_page27.htm>Fig.

>8. This process which may strike many target tissues is shown in Table 1.

>

>IMMUNOSCIENCES LAB., INC. - services

>

>

>

>

><http://www.immuno-sci-lab.com/tests.html>

>TESTS

>

>

><http://www.immuno-sci-lab.com/form.html>

>FORM

>

>

><http://www.immuno-sci-lab.com/images/sampleform2.GIF>

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>

>

>

>IMMUNOSCIENCES LOGO

>

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><http://promos.hotbar.com/promos/promodll.dll?RunPromo & El= & SG= & RAND=84572 & partn\

er=hbtools>

>Upgrade Your Email - Click here!

>

>

>

[Guest guest]

Thank you Dearest Lynda:

I had severe brain fog when I destroyed the folders, now I wish that I had

kept them. Someone wrote to me this morning, but I am not sure who she is.

When she can prove to me that she is a safe contact, she will get the rest

of my research.

I too did most of my research when I was too sick, but was my

runner. He knew the medical library very well and he could find all of the

articles that I had ticked off. Then we would photocopy for hours, we did

this for years. This is when we would mail or hand deliver material to the

sick women. We no longer do this. I have not destroyed your material, but

some of it is badly faded because Lori had faxed it to me...bless her

precious heart.

Love you always..........Lea

~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~`

Fwd: Immunosciences Lab: Autoimmune Diseases

>>

>>

>>

>>

>>Autoimmune Diseases

>>Page 1 of 2

>>

>>Autoimmunity, in which the immune system recognizes and attacks the

>>self's own tissue, is not as simple as it seems. Self-recognition

>>appears to be at the heart of health as well as of certain diseases.

>> It is generally assumed that the main job of the immune system is

>> to distinguish between what is " self " and what is " not self " . Once

>> the distinction has been made, " self " is pre-served and " not self "

>> is destroyed. At the most general level, of course, this is true,

>> and human beings remain alive and healthy only because it is so.

>> Recently it has become clear, however, that at a finer level of

>> detail the distinction between self and other is not absolute. One

>> of the paths to this insight has been provided by the autoimmune

>> disorders, in which the immune system attacks normal, healthy

>> tissue. Autoimmune disease, which may be crippling or fatal, can

>> strike any tissue or organ. Its victims are often in the prime of

>> life, and for unknown reasons they are more frequently women than men.

>>Research work on a form of autoimmune arthritis shows that the basis

>>of autoimmunity may be a resemblance between a specific foreign

>>molecule and a molecule of the self. This finding is consistent with

>>a model of the immune system in which the immune system receptors

>>that perform the work of recognition can themselves be recognized by

>>other receptors. Such " self-recognition, " which was strictly

>>outlawed by older models of the immune sys-tem, may form the basis

>>of a network whose equilibrium keeps the body healthy. When it is

>>disrupted, as it is in autoimmunity, disease results.

>>This new picture, in which self and world are no longer absolutely

>>distinct, has already begun to yield practical benefits in the form

>>of vaccines that may ultimately ease the substantial suffering

>>caused by autoimmune diseases. The list of autoimmune diseases is

>>both long and disturbing. It includes multiple sclerosis, in which

>>the tissue attacked is myelin (a sub-stance that sheathes nerves in

>>the central nervous system); myasthenia gravis, in which the target

>>is a receptor molecule for the important neurotransmitter

>>acetylcholine; rheumatoid arthritis, whose target is the peripheral

>>joint; type I (juvenile) diabetes mellitus, in which the cells

>>producing insulin are destroyed, and systemic lupus erythematosus,

>>in which DNA, blood vessels, skin and kidneys are attacked. In

>>contrast to AIDS, which is marked by an in activation of key cells

>>in the immune system, in all these diseases the immunological

>>response is strong and well focused; it is, however, directed at

>>some essential component of the body. These immunological attacks

>>are detected in clinical laboratory by the measurement of

>>tissue-specific and tissue non-specific antibodies.

>>

>>Autoimmune Diseases

>>Page 2 of 2

>>

>>Autoimmune diseases can be separated broadly into two categories.

>>One group is characterized by the presence of auto antibodies which

>>are broadly reactive with nuclear or cytoplasmic antigens and do not

>>demonstrate any tissue specificity. Included in this group are

>>diseases such as rheumatoid arthritis, SLE, mixed connective tissue

>>disease, scleroderma, Sjogren's syndrome, and

>>dermatomyositis/polymyositis. A second group of autoimmune diseases

>>is characterized by autoantibodies which demonstrate tissue

>>specificity. These diseases include thyroiditis, chronic liver

>>diseases (including primary biliary cirrhosis and chronic active

>>Hepatitis), certain cases of pernicious anemia, and myasthenia gravis.

>>The autoantibodies which appear in these disease states demonstrate

>>different degrees of specificity with respect to both tissue and

>>species. Tissue-specific autoantibodies include those which react

>>against erythrocyte stromalantigens, platelets, antihemophilic

>>globulin, thyroid tissue and other tissues, and g-globulin

>>(rheumatoid factor). Autoantibodies without tissue specificity

>>include anti-nuclear, anti-nucleoprotien, anti-DNA, and

>>anti-cytoplasmicantibodies. Autoantibodies directed against the

>>formed elements of the blood can undoubtedly induce disease by

>>causing the destruction and removal of these cells from the

>>circulation. However, it is far less certain whether other types of

>>autoantibodies play pathogenic roles.

>>Most studies of autoantibodies in both humans and animals have

>>concentrated on the reactivity of humoral constituents. However, it

>>should be remembered that the cell-mediated immune response is far

>>more efficient in terms of tissue destruction. Since humoral

>>antibodies have been shown, under appropriate circumstances, to

>>prevent cell-mediated tissue damage, it is conceivable that they may

>>have a protective rather than a destructive function. There is

>>presently no indication whether the autoantibodies detected in human

>>disease rep-resent a primary manifestation of the disease itself or

>>a secondary event stimulated by an underlying, but unrelated,

>>abnormality. In ether event, the mechanisms which may be responsible

>>for the abrogation of natural immunologic tolerance are worthy of

>>consideration. Four general mechanisms have been proposed in the

>>pathogenesis of autoantibody production:1.alterations in the

>>structure or distribution of antigens;2.formation of cross-reactive

>>antibodies following exposure to extrinsic antigens;3.release of

>>sequestered antigens; and4.abnormalities of immunologic responsive-ness.

>>An assault on the self through molecular mimicry or antigenic

>>similarity between foreign antigens (virus, bacreria) and human

>>tissue antigens which may end with an autoimmune disease is

>>presented in <http://www.immuno-sci-lab.com/2003_cat_page27.htm>Fig.

>>8. This process which may strike many target tissues is shown in Table

1.

>>

>>IMMUNOSCIENCES LAB., INC. - services

>>

>>

>>

>>

>><http://www.immuno-sci-lab.com/tests.html>

>>TESTS

>>

>>

>><http://www.immuno-sci-lab.com/form.html>

>>FORM

>>

>>

>><http://www.immuno-sci-lab.com/images/sampleform2.GIF>

>>SAMPLE

>>

>>

>>

>>

>>IMMUNOSCIENCES LOGO

>>

>>

>>

>>

>>

>>

>>

>><http://promos.hotbar.com/promos/promodll.dll?RunPromo & El= & SG= & RAND=84572 & part\

ner=hbtools>

>>Upgrade Your Email - Click here!

>>

>>

>>

>

>

>

>

>

>

[Guest guest]

Honey, it was a Court Order...love...Lea

~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~```

Re: Fwd: Immunosciences Lab: Autoimmune Diseases

Lea,

I been reading and just wondered why? You have to destroy all your hard work. I missed that part.

Donna

[Guest guest]

Honey, this woman was not sick, she was $$$ hungry. People will do almost anything for money.

I am so sorry that you must suffer so much. I too suffer every day, but we might have to learn how to cope with our illness. Honey, try to take one day at a time. This will not be easy, but I did make many wreaths and made some beautiful nighties for our grand-daughters. Later, I learned to perfect my pastry and made some beautiful pastries for friends. Now, I am too broken to do anything, but I will get help because when people tell you that you know nothing, you start to believe them.

This is so tragic and it should never have happened. The plastic surgeons are still lying to women, they do not care about our pain. They are doing this just to line their pockets, it is all about money and power. We know the truth.

Stay close...love always........Lea

~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~

Re: Fwd: Immunosciences Lab: Autoimmune Diseases

Lea,

I am so sorry I didn't understand why, I must have missed that post. That is awful, I just wonder if the judge was sick from implants, if they would react this way? It is sad that we all have to do our own Research anyway, struggle daily to find a doctor who will take you seriously. I still have not found one doctor, other than Dr. Kolb, to take me serious. I am exhausted and to the point of giving up really. It is sad Lea that all your Research had to be destroyed, I will never understand why a judge would order that????

Donna

[Guest guest]

Lynda, good for you. I am just sickened and my heart feels like lead

in my chest right now. I'm beginning to see more and more the crime

that has and still is, being commited against women with and without

implants. The whole image thing is more than a plague.

God bless you for all the work you've done...I'm going to do some

research myself. I really respect you girls for what you're doing

and the steadfastness with helping others.

Love & All God's Blessings,

Sunny

>

> >Dearest Rogene:

> >

> >Thank you for posting this information and for the " contact " . I

> >still have folders that will not be deleted, but some of the hard

> >copies have been destroyed. It hurts to help me to destroy

all

> >of my hard work, but we have no choice. This was not about money,

I

> >just knew too much in an Oil Rich province.

> >

> >Love you honey...Lea

> >~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~``

> > Fwd: Immunosciences Lab: Autoimmune

Diseases

> >

> >

> >

> >

> >Autoimmune Diseases

> >Page 1 of 2

> >

> >Autoimmunity, in which the immune system recognizes and attacks

the

> >self's own tissue, is not as simple as it seems. Self-recognition

> >appears to be at the heart of health as well as of certain

diseases.

> > It is generally assumed that the main job of the immune system

is

> > to distinguish between what is " self " and what is " not self " .

Once

> > the distinction has been made, " self " is pre-served and " not

self "

> > is destroyed. At the most general level, of course, this is true,

> > and human beings remain alive and healthy only because it is so.

> > Recently it has become clear, however, that at a finer level of

> > detail the distinction between self and other is not absolute.

One

> > of the paths to this insight has been provided by the autoimmune

> > disorders, in which the immune system attacks normal, healthy

> > tissue. Autoimmune disease, which may be crippling or fatal, can

> > strike any tissue or organ. Its victims are often in the prime of

> > life, and for unknown reasons they are more frequently women than

men.

> >Research work on a form of autoimmune arthritis shows that the

basis

> >of autoimmunity may be a resemblance between a specific foreign

> >molecule and a molecule of the self. This finding is consistent

with

> >a model of the immune system in which the immune system receptors

> >that perform the work of recognition can themselves be recognized

by

> >other receptors. Such " self-recognition, " which was strictly

> >outlawed by older models of the immune sys-tem, may form the basis

> >of a network whose equilibrium keeps the body healthy. When it is

> >disrupted, as it is in autoimmunity, disease results.

> >This new picture, in which self and world are no longer absolutely

> >distinct, has already begun to yield practical benefits in the

form

> >of vaccines that may ultimately ease the substantial suffering

> >caused by autoimmune diseases. The list of autoimmune diseases is

> >both long and disturbing. It includes multiple sclerosis, in which

> >the tissue attacked is myelin (a sub-stance that sheathes nerves

in

> >the central nervous system); myasthenia gravis, in which the

target

> >is a receptor molecule for the important neurotransmitter

> >acetylcholine; rheumatoid arthritis, whose target is the

peripheral

> >joint; type I (juvenile) diabetes mellitus, in which the cells

> >producing insulin are destroyed, and systemic lupus erythematosus,

> >in which DNA, blood vessels, skin and kidneys are attacked. In

> >contrast to AIDS, which is marked by an in activation of key cells

> >in the immune system, in all these diseases the immunological

> >response is strong and well focused; it is, however, directed at

> >some essential component of the body. These immunological attacks

> >are detected in clinical laboratory by the measurement of

> >tissue-specific and tissue non-specific antibodies.

> >

> >Autoimmune Diseases

> >Page 2 of 2

> >

> >Autoimmune diseases can be separated broadly into two categories.

> >One group is characterized by the presence of auto antibodies

which

> >are broadly reactive with nuclear or cytoplasmic antigens and do

not

> >demonstrate any tissue specificity. Included in this group are

> >diseases such as rheumatoid arthritis, SLE, mixed connective

tissue

> >disease, scleroderma, Sjogren's syndrome, and

> >dermatomyositis/polymyositis. A second group of autoimmune

diseases

> >is characterized by autoantibodies which demonstrate tissue

> >specificity. These diseases include thyroiditis, chronic liver

> >diseases (including primary biliary cirrhosis and chronic active

> >Hepatitis), certain cases of pernicious anemia, and myasthenia

gravis.

> >The autoantibodies which appear in these disease states

demonstrate

> >different degrees of specificity with respect to both tissue and

> >species. Tissue-specific autoantibodies include those which react

> >against erythrocyte stromalantigens, platelets, antihemophilic

> >globulin, thyroid tissue and other tissues, and g-globulin

> >(rheumatoid factor). Autoantibodies without tissue specificity

> >include anti-nuclear, anti-nucleoprotien, anti-DNA, and

> >anti-cytoplasmicantibodies. Autoantibodies directed against the

> >formed elements of the blood can undoubtedly induce disease by

> >causing the destruction and removal of these cells from the

> >circulation. However, it is far less certain whether other types

of

> >autoantibodies play pathogenic roles.

> >Most studies of autoantibodies in both humans and animals have

> >concentrated on the reactivity of humoral constituents. However,

it

> >should be remembered that the cell-mediated immune response is far

> >more efficient in terms of tissue destruction. Since humoral

> >antibodies have been shown, under appropriate circumstances, to

> >prevent cell-mediated tissue damage, it is conceivable that they

may

> >have a protective rather than a destructive function. There is

> >presently no indication whether the autoantibodies detected in

human

> >disease rep-resent a primary manifestation of the disease itself

or

> >a secondary event stimulated by an underlying, but unrelated,

> >abnormality. In ether event, the mechanisms which may be

responsible

> >for the abrogation of natural immunologic tolerance are worthy of

> >consideration. Four general mechanisms have been proposed in the

> >pathogenesis of autoantibody production:1.alterations in the

> >structure or distribution of antigens;2.formation of cross-

reactive

> >antibodies following exposure to extrinsic antigens;3.release of

> >sequestered antigens; and4.abnormalities of immunologic responsive-

ness.

> >An assault on the self through molecular mimicry or antigenic

> >similarity between foreign antigens (virus, bacreria) and human

> >tissue antigens which may end with an autoimmune disease is

> >presented in <http://www.immuno-sci-

lab.com/2003_cat_page27.htm>Fig.

> >8. This process which may strike many target tissues is shown in

Table 1.

> >

> >IMMUNOSCIENCES LAB., INC. - services

> >

> >

> >

> >

> ><http://www.immuno-sci-lab.com/tests.html>

> >TESTS

> >

> >

> ><http://www.immuno-sci-lab.com/form.html>

> >FORM

> >

> >

> ><http://www.immuno-sci-lab.com/images/sampleform2.GIF>

> >SAMPLE

> >

> >

> >

> >

> >IMMUNOSCIENCES LOGO

> >

> >

> >

> >

> >

> >

> >

> ><http://promos.hotbar.com/promos/promodll.dll?

RunPromo & El= & SG= & RAND=84572 & partner=hbtools>

> >Upgrade Your Email - Click here!

> >

> >

> >

>

[Guest guest]

I'm in the dark here! On what basis can a judge court order someone

destroy information that has been allowed in medical libraries?? Help

me out here...I'm trying to understand this...sounds like another

judge paid off.

Love,

Sunny

>

> Lea,

>

> I am so sorry I didn't understand why, I must have missed that

post. That is

> awful, I just wonder if the judge was sick from implants, if they

would react

> this way? It is sad that we all have to do our own Research

anyway, struggle

> daily to find a doctor who will take you seriously. I still have

not found

> one doctor, other than Dr. Kolb, to take me serious. I am

exhausted and to the

> point of giving up really. It is sad Lea that all your Research

had to be

> destroyed, I will never understand why a judge would order that????

>

> Donna

>

[Guest guest]

Lynda,

I had this experience today, I went to a rheumy today who has seen me

on three occasions, he has run two tests, Sed rate is 30 and have

numerous other quetions that I need tests for, He simply thinks that

all my joint pain and muscle weakness and uncontrollable twitching

and muscle cramping would go away if I just do strenous excercise,

fight through the pain, I have pain in all my joints and muscles. I

asked him about physical therapy or aqua therapy he said those are

not intense enough , This is BS I am aware some stretching and

walking and light excercise would be beneficial, But I just had

surgery 1 month ago and have so much pain in the

hips,neck,choulders,ankles,knees, elows, tailbone, breast with

hematoma and infection migraines, dizzyness. He was very arrogant and

I asked what do I do about the silicone in my bood? He said I don't

know ask your PCD.It would be unwise for me to do this, but they

can't think of anything else to say, just wanted me to go away, I

told him I need copies of my records because I won't be needing him

anymore. I can barely walk 20 minutes.

TerriP

> > >

> > > >Dearest Rogene:

> > > >

> > > >Thank you for posting this information and for the " contact " . I

> > > >still have folders that will not be deleted, but some of the

hard

> > > >copies have been destroyed. It hurts to help me to

destroy

> >all

> > > >of my hard work, but we have no choice. This was not about

money,

> >I

> > > >just knew too much in an Oil Rich province.

> > > >

> > > >Love you honey...Lea

> > > >~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~``

> > > > Fwd: Immunosciences Lab: Autoimmune

> >Diseases

> > > >

> > > >

> > > >

> > > >

> > > >Autoimmune Diseases

> > > >Page 1 of 2

> > > >

> > > >Autoimmunity, in which the immune system recognizes and attacks

> >the

> > > >self's own tissue, is not as simple as it seems. Self-

recognition

> > > >appears to be at the heart of health as well as of certain

> >diseases.

> > > > It is generally assumed that the main job of the immune system

> >is

> > > > to distinguish between what is " self " and what is " not self " .

> >Once

> > > > the distinction has been made, " self " is pre-served and " not

> >self "

> > > > is destroyed. At the most general level, of course, this is

true,

> > > > and human beings remain alive and healthy only because it is

so.

> > > > Recently it has become clear, however, that at a finer level

of

> > > > detail the distinction between self and other is not absolute.

> >One

> > > > of the paths to this insight has been provided by the

autoimmune

> > > > disorders, in which the immune system attacks normal, healthy

> > > > tissue. Autoimmune disease, which may be crippling or fatal,

can

> > > > strike any tissue or organ. Its victims are often in the

prime of

> > > > life, and for unknown reasons they are more frequently women

than

> >men.

> > > >Research work on a form of autoimmune arthritis shows that the

> >basis

> > > >of autoimmunity may be a resemblance between a specific foreign

> > > >molecule and a molecule of the self. This finding is consistent

> >with

> > > >a model of the immune system in which the immune system

receptors

> > > >that perform the work of recognition can themselves be

recognized

> >by

> > > >other receptors. Such " self-recognition, " which was strictly

> > > >outlawed by older models of the immune sys-tem, may form the

basis

> > > >of a network whose equilibrium keeps the body healthy. When it

is

> > > >disrupted, as it is in autoimmunity, disease results.

> > > >This new picture, in which self and world are no longer

absolutely

> > > >distinct, has already begun to yield practical benefits in the

> >form

> > > >of vaccines that may ultimately ease the substantial suffering

> > > >caused by autoimmune diseases. The list of autoimmune diseases

is

> > > >both long and disturbing. It includes multiple sclerosis, in

which

> > > >the tissue attacked is myelin (a sub-stance that sheathes

nerves

> >in

> > > >the central nervous system); myasthenia gravis, in which the

> >target

> > > >is a receptor molecule for the important neurotransmitter

> > > >acetylcholine; rheumatoid arthritis, whose target is the

> >peripheral

> > > >joint; type I (juvenile) diabetes mellitus, in which the cells

> > > >producing insulin are destroyed, and systemic lupus

erythematosus,

> > > >in which DNA, blood vessels, skin and kidneys are attacked. In

> > > >contrast to AIDS, which is marked by an in activation of key

cells

> > > >in the immune system, in all these diseases the immunological

> > > >response is strong and well focused; it is, however, directed

at

> > > >some essential component of the body. These immunological

attacks

> > > >are detected in clinical laboratory by the measurement of

> > > >tissue-specific and tissue non-specific antibodies.

> > > >

> > > >Autoimmune Diseases

> > > >Page 2 of 2

> > > >

> > > >Autoimmune diseases can be separated broadly into two

categories.

> > > >One group is characterized by the presence of auto antibodies

> >which

> > > >are broadly reactive with nuclear or cytoplasmic antigens and

do

> >not

> > > >demonstrate any tissue specificity. Included in this group are

> > > >diseases such as rheumatoid arthritis, SLE, mixed connective

> >tissue

> > > >disease, scleroderma, Sjogren's syndrome, and

> > > >dermatomyositis/polymyositis. A second group of autoimmune

> >diseases

> > > >is characterized by autoantibodies which demonstrate tissue

> > > >specificity. These diseases include thyroiditis, chronic liver

> > > >diseases (including primary biliary cirrhosis and chronic

active

> > > >Hepatitis), certain cases of pernicious anemia, and myasthenia

> >gravis.

> > > >The autoantibodies which appear in these disease states

> >demonstrate

> > > >different degrees of specificity with respect to both tissue

and

> > > >species. Tissue-specific autoantibodies include those which

react

> > > >against erythrocyte stromalantigens, platelets, antihemophilic

> > > >globulin, thyroid tissue and other tissues, and g-globulin

> > > >(rheumatoid factor). Autoantibodies without tissue specificity

> > > >include anti-nuclear, anti-nucleoprotien, anti-DNA, and

> > > >anti-cytoplasmicantibodies. Autoantibodies directed against the

> > > >formed elements of the blood can undoubtedly induce disease by

> > > >causing the destruction and removal of these cells from the

> > > >circulation. However, it is far less certain whether other

types

> >of

> > > >autoantibodies play pathogenic roles.

> > > >Most studies of autoantibodies in both humans and animals have

> > > >concentrated on the reactivity of humoral constituents.

However,

> >it

> > > >should be remembered that the cell-mediated immune response is

far

> > > >more efficient in terms of tissue destruction. Since humoral

> > > >antibodies have been shown, under appropriate circumstances, to

> > > >prevent cell-mediated tissue damage, it is conceivable that

they

> >may

> > > >have a protective rather than a destructive function. There is

> > > >presently no indication whether the autoantibodies detected in

> >human

> > > >disease rep-resent a primary manifestation of the disease

itself

> >or

> > > >a secondary event stimulated by an underlying, but unrelated,

> > > >abnormality. In ether event, the mechanisms which may be

> >responsible

> > > >for the abrogation of natural immunologic tolerance are worthy

of

> > > >consideration. Four general mechanisms have been proposed in

the

> > > >pathogenesis of autoantibody production:1.alterations in the

> > > >structure or distribution of antigens;2.formation of cross-

> >reactive

> > > >antibodies following exposure to extrinsic antigens;3.release

of

> > > >sequestered antigens; and4.abnormalities of immunologic

responsive-

> >ness.

> > > >An assault on the self through molecular mimicry or antigenic

> > > >similarity between foreign antigens (virus, bacreria) and human

> > > >tissue antigens which may end with an autoimmune disease is

> > > >presented in <<http://www.immuno-sci->http://www.immuno-sci-

> >lab.com/2003_cat_page27.htm>Fig.

> > > >8. This process which may strike many target tissues is shown

in

> >Table 1.

> > > >

> > > >IMMUNOSCIENCES LAB., INC. - services

> > > >

> > > >

> > > >

> > > >

> > > ><<http://www.immuno-sci-lab.com/tests.html>http://www.immuno-

sci-

> > lab.com/tests.html>

> > > >TESTS

> > > >

> > > >

> > > ><<http://www.immuno-sci-lab.com/form.html>http://www.immuno-

sci-l

> > ab.com/form.html>

> > > >FORM

> > > >

> > > >

> > > ><<http://www.immuno-sci-

lab.com/images/sampleform2.GIF>http://www

> > .immuno-sci-lab.com/images/sampleform2.GIF>

> > > >SAMPLE

> > > >

> > > >

> > > >

> > > >

> > > >IMMUNOSCIENCES LOGO

> > > >

> > > >

> > > >

> > > >

> > > >

> > > >

> > > >

> > > ><<http://promos.hotbar.com/promos/promodll.dll?

>http://promos.hot

> > bar.com/promos/promodll.dll?

> >RunPromo & El= & SG= & RAND=84572 & partner=hbtools>

> > > >Upgrade Your Email - Click here!

> > > >

> > > >

> > > >

> > >

> >

> >

>

[Guest guest]

Kenda,

Thank you for your reply, This is the 3rd visit to him, And the 2nd

time I cryed after leaving his office, I am not a cryer, I am a tough

cookie, but he must be biased, If he would have read my medical

records that I aactually carry we me for appointments, I have had my

illness for 10 years, I was only this heavy 169 5,1' since explant

last year. my weight spike is not from stting around eating bon bons.

I have eating healthy since I had my explant. And I have gained 25

lbs since Last August. I think he thinks my pain in joints and

muscle, are caused from the weight, like you caused this so I am not

going to bother to actually help you with your health issues.

> >>>>

> >>>>> Dearest Rogene:

> >>>>>

> >>>>> Thank you for posting this information and for the " contact " .

I

> >>>>> still have folders that will not be deleted, but some of the

> > hard

> >>>>> copies have been destroyed. It hurts to help me to

> > destroy

> >>> all

> >>>>> of my hard work, but we have no choice. This was not about

> > money,

> >>> I

> >>>>> just knew too much in an Oil Rich province.

> >>>>>

> >>>>> Love you honey...Lea

> >>>>> ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~``

> >>>>> Fwd: Immunosciences Lab: Autoimmune

> >>> Diseases

> >>>>>

> >>>>>

> >>>>>

> >>>>>

> >>>>> Autoimmune Diseases

> >>>>> Page 1 of 2

> >>>>>

> >>>>> Autoimmunity, in which the immune system recognizes and

attacks

> >>> the

> >>>>> self's own tissue, is not as simple as it seems. Self-

> > recognition

> >>>>> appears to be at the heart of health as well as of certain

> >>> diseases.

> >>>>> It is generally assumed that the main job of the immune system

> >>> is

> >>>>> to distinguish between what is " self " and what is " not self " .

> >>> Once

> >>>>> the distinction has been made, " self " is pre-served and " not

> >>> self "

> >>>>> is destroyed. At the most general level, of course, this is

> > true,

> >>>>> and human beings remain alive and healthy only because it is

> > so.

> >>>>> Recently it has become clear, however, that at a finer level

> > of

> >>>>> detail the distinction between self and other is not absolute.

> >>> One

> >>>>> of the paths to this insight has been provided by the

> > autoimmune

> >>>>> disorders, in which the immune system attacks normal, healthy

> >>>>> tissue. Autoimmune disease, which may be crippling or fatal,

> > can

> >>>>> strike any tissue or organ. Its victims are often in the

> > prime of

> >>>>> life, and for unknown reasons they are more frequently women

> > than

> >>> men.

> >>>>> Research work on a form of autoimmune arthritis shows that the

> >>> basis

> >>>>> of autoimmunity may be a resemblance between a specific

foreign

> >>>>> molecule and a molecule of the self. This finding is

consistent

> >>> with

> >>>>> a model of the immune system in which the immune system

> > receptors

> >>>>> that perform the work of recognition can themselves be

> > recognized

> >>> by

> >>>>> other receptors. Such " self-recognition, " which was strictly

> >>>>> outlawed by older models of the immune sys-tem, may form the

> > basis

> >>>>> of a network whose equilibrium keeps the body healthy. When it

> > is

> >>>>> disrupted, as it is in autoimmunity, disease results.

> >>>>> This new picture, in which self and world are no longer

> > absolutely

> >>>>> distinct, has already begun to yield practical benefits in the

> >>> form

> >>>>> of vaccines that may ultimately ease the substantial suffering

> >>>>> caused by autoimmune diseases. The list of autoimmune diseases

> > is

> >>>>> both long and disturbing. It includes multiple sclerosis, in

> > which

> >>>>> the tissue attacked is myelin (a sub-stance that sheathes

> > nerves

> >>> in

> >>>>> the central nervous system); myasthenia gravis, in which the

> >>> target

> >>>>> is a receptor molecule for the important neurotransmitter

> >>>>> acetylcholine; rheumatoid arthritis, whose target is the

> >>> peripheral

> >>>>> joint; type I (juvenile) diabetes mellitus, in which the cells

> >>>>> producing insulin are destroyed, and systemic lupus

> > erythematosus,

> >>>>> in which DNA, blood vessels, skin and kidneys are attacked. In

> >>>>> contrast to AIDS, which is marked by an in activation of key

> > cells

> >>>>> in the immune system, in all these diseases the immunological

> >>>>> response is strong and well focused; it is, however, directed

> > at

> >>>>> some essential component of the body. These immunological

> > attacks

> >>>>> are detected in clinical laboratory by the measurement of

> >>>>> tissue-specific and tissue non-specific antibodies.

> >>>>>

> >>>>> Autoimmune Diseases

> >>>>> Page 2 of 2

> >>>>>

> >>>>> Autoimmune diseases can be separated broadly into two

> > categories.

> >>>>> One group is characterized by the presence of auto antibodies

> >>> which

> >>>>> are broadly reactive with nuclear or cytoplasmic antigens and

> > do

> >>> not

> >>>>> demonstrate any tissue specificity. Included in this group are

> >>>>> diseases such as rheumatoid arthritis, SLE, mixed connective

> >>> tissue

> >>>>> disease, scleroderma, Sjogren's syndrome, and

> >>>>> dermatomyositis/polymyositis. A second group of autoimmune

> >>> diseases

> >>>>> is characterized by autoantibodies which demonstrate tissue

> >>>>> specificity. These diseases include thyroiditis, chronic liver

> >>>>> diseases (including primary biliary cirrhosis and chronic

> > active

> >>>>> Hepatitis), certain cases of pernicious anemia, and myasthenia

> >>> gravis.

> >>>>> The autoantibodies which appear in these disease states

> >>> demonstrate

> >>>>> different degrees of specificity with respect to both tissue

> > and

> >>>>> species. Tissue-specific autoantibodies include those which

> > react

> >>>>> against erythrocyte stromalantigens, platelets, antihemophilic

> >>>>> globulin, thyroid tissue and other tissues, and g-globulin

> >>>>> (rheumatoid factor). Autoantibodies without tissue specificity

> >>>>> include anti-nuclear, anti-nucleoprotien, anti-DNA, and

> >>>>> anti-cytoplasmicantibodies. Autoantibodies directed against

the

> >>>>> formed elements of the blood can undoubtedly induce disease by

> >>>>> causing the destruction and removal of these cells from the

> >>>>> circulation. However, it is far less certain whether other

> > types

> >>> of

> >>>>> autoantibodies play pathogenic roles.

> >>>>> Most studies of autoantibodies in both humans and animals have

> >>>>> concentrated on the reactivity of humoral constituents.

> > However,

> >>> it

> >>>>> should be remembered that the cell-mediated immune response is

> > far

> >>>>> more efficient in terms of tissue destruction. Since humoral

> >>>>> antibodies have been shown, under appropriate circumstances,

to

> >>>>> prevent cell-mediated tissue damage, it is conceivable that

> > they

> >>> may

> >>>>> have a protective rather than a destructive function. There is

> >>>>> presently no indication whether the autoantibodies detected in

> >>> human

> >>>>> disease rep-resent a primary manifestation of the disease

> > itself

> >>> or

> >>>>> a secondary event stimulated by an underlying, but unrelated,

> >>>>> abnormality. In ether event, the mechanisms which may be

> >>> responsible

> >>>>> for the abrogation of natural immunologic tolerance are worthy

> > of

> >>>>> consideration. Four general mechanisms have been proposed in

> > the

> >>>>> pathogenesis of autoantibody production:1.alterations in the

> >>>>> structure or distribution of antigens;2.formation of cross-

> >>> reactive

> >>>>> antibodies following exposure to extrinsic antigens;3.release

> > of

> >>>>> sequestered antigens; and4.abnormalities of immunologic

> > responsive-

> >>> ness.

> >>>>> An assault on the self through molecular mimicry or antigenic

> >>>>> similarity between foreign antigens (virus, bacreria) and

human

> >>>>> tissue antigens which may end with an autoimmune disease is

> >>>>> presented in <<http://www.immuno-sci->http://www.immuno-sci-

> >>> lab.com/2003_cat_page27.htm>Fig.

> >>>>> 8. This process which may strike many target tissues is shown

> > in

> >>> Table 1.

> >>>>>

> >>>>> IMMUNOSCIENCES LAB., INC. - services

> >>>>>

> >>>>>

> >>>>>

> >>>>>

> >>>>> <<http://www.immuno-sci-lab.com/tests.html>http://www.immuno-

> > sci-

> >>> lab.com/tests.html>

> >>>>> TESTS

> >>>>>

> >>>>>

> >>>>> <<http://www.immuno-sci-lab.com/form.html>http://www.immuno-

> > sci-l

> >>> ab.com/form.html>

> >>>>> FORM

> >>>>>

> >>>>>

> >>>>> <<http://www.immuno-sci-

> > lab.com/images/sampleform2.GIF>http://www

> >>> .immuno-sci-lab.com/images/sampleform2.GIF>

> >>>>> SAMPLE

> >>>>>

> >>>>>

> >>>>>

> >>>>>

> >>>>> IMMUNOSCIENCES LOGO

> >>>>>

> >>>>>

> >>>>>

> >>>>>

> >>>>>

> >>>>>

> >>>>>

> >>>>> <<http://promos.hotbar.com/promos/promodll.dll?

> >> http://promos.hot

> >>> bar.com/promos/promodll.dll?

> >>> RunPromo & El= & SG= & RAND=84572 & partner=hbtools>

> >>>>> Upgrade Your Email - Click here!

> >>>>>

> >>>>>

> >>>>>

> >>>>

> >>>

> >>>

> >>

> >

> >

> >

>

[Guest guest]

Terri,

I hope you find another doctor. That one sounds like a real creep.

Women still have a ways to go, to be treated as equals, sadly -

One bright spot -- this country will now have its first-ever woman Speaker of

the House.

> >>>>>>

> >>>>>>> Dearest Rogene:

> >>>>>>>

> >>>>>>> Thank you for posting this information and for the " contact " .

> > I

> >>>>>>> still have folders that will not be deleted, but some of the

> >>> hard

> >>>>>>> copies have been destroyed. It hurts to help me to

> >>> destroy

> >>>>> all

> >>>>>>> of my hard work, but we have no choice. This was not about

> >>> money,

> >>>>> I

> >>>>>>> just knew too much in an Oil Rich province.

> >>>>>>>

> >>>>>>> Love you honey...Lea

> >>>>>>> ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~``

> >>>>>>> Fwd: Immunosciences Lab: Autoimmune

> >>>>> Diseases

> >>>>>>>

> >>>>>>>

> >>>>>>>

> >>>>>>>

> >>>>>>> Autoimmune Diseases

> >>>>>>> Page 1 of 2

> >>>>>>>

> >>>>>>> Autoimmunity, in which the immune system recognizes and

> > attacks

> >>>>> the

> >>>>>>> self's own tissue, is not as simple as it seems. Self-

> >>> recognition

> >>>>>>> appears to be at the heart of health as well as of certain

> >>>>> diseases.

> >>>>>>> It is generally assumed that the main job of the immune system

> >>>>> is

> >>>>>>> to distinguish between what is " self " and what is " not self " .

> >>>>> Once

> >>>>>>> the distinction has been made, " self " is pre-served and " not

> >>>>> self "

> >>>>>>> is destroyed. At the most general level, of course, this is

> >>> true,

> >>>>>>> and human beings remain alive and healthy only because it is

> >>> so.

> >>>>>>> Recently it has become clear, however, that at a finer level

> >>> of

> >>>>>>> detail the distinction between self and other is not absolute.

> >>>>> One

> >>>>>>> of the paths to this insight has been provided by the

> >>> autoimmune

> >>>>>>> disorders, in which the immune system attacks normal, healthy

> >>>>>>> tissue. Autoimmune disease, which may be crippling or fatal,

> >>> can

> >>>>>>> strike any tissue or organ. Its victims are often in the

> >>> prime of

> >>>>>>> life, and for unknown reasons they are more frequently women

> >>> than

> >>>>> men.

> >>>>>>> Research work on a form of autoimmune arthritis shows that the

> >>>>> basis

> >>>>>>> of autoimmunity may be a resemblance between a specific

> > foreign

> >>>>>>> molecule and a molecule of the self. This finding is

> > consistent

> >>>>> with

> >>>>>>> a model of the immune system in which the immune system

> >>> receptors

> >>>>>>> that perform the work of recognition can themselves be

> >>> recognized

> >>>>> by

> >>>>>>> other receptors. Such " self-recognition, " which was strictly

> >>>>>>> outlawed by older models of the immune sys-tem, may form the

> >>> basis

> >>>>>>> of a network whose equilibrium keeps the body healthy. When it

> >>> is

> >>>>>>> disrupted, as it is in autoimmunity, disease results.

> >>>>>>> This new picture, in which self and world are no longer

> >>> absolutely

> >>>>>>> distinct, has already begun to yield practical benefits in the

> >>>>> form

> >>>>>>> of vaccines that may ultimately ease the substantial suffering

> >>>>>>> caused by autoimmune diseases. The list of autoimmune diseases

> >>> is

> >>>>>>> both long and disturbing. It includes multiple sclerosis, in

> >>> which

> >>>>>>> the tissue attacked is myelin (a sub-stance that sheathes

> >>> nerves

> >>>>> in

> >>>>>>> the central nervous system); myasthenia gravis, in which the

> >>>>> target

> >>>>>>> is a receptor molecule for the important neurotransmitter

> >>>>>>> acetylcholine; rheumatoid arthritis, whose target is the

> >>>>> peripheral

> >>>>>>> joint; type I (juvenile) diabetes mellitus, in which the cells

> >>>>>>> producing insulin are destroyed, and systemic lupus

> >>> erythematosus,

> >>>>>>> in which DNA, blood vessels, skin and kidneys are attacked. In

> >>>>>>> contrast to AIDS, which is marked by an in activation of key

> >>> cells

> >>>>>>> in the immune system, in all these diseases the immunological

> >>>>>>> response is strong and well focused; it is, however, directed

> >>> at

> >>>>>>> some essential component of the body. These immunological

> >>> attacks

> >>>>>>> are detected in clinical laboratory by the measurement of

> >>>>>>> tissue-specific and tissue non-specific antibodies.

> >>>>>>>

> >>>>>>> Autoimmune Diseases

> >>>>>>> Page 2 of 2

> >>>>>>>

> >>>>>>> Autoimmune diseases can be separated broadly into two

> >>> categories.

> >>>>>>> One group is characterized by the presence of auto antibodies

> >>>>> which

> >>>>>>> are broadly reactive with nuclear or cytoplasmic antigens and

> >>> do

> >>>>> not

> >>>>>>> demonstrate any tissue specificity. Included in this group are

> >>>>>>> diseases such as rheumatoid arthritis, SLE, mixed connective

> >>>>> tissue

> >>>>>>> disease, scleroderma, Sjogren's syndrome, and

> >>>>>>> dermatomyositis/polymyositis. A second group of autoimmune

> >>>>> diseases

> >>>>>>> is characterized by autoantibodies which demonstrate tissue

> >>>>>>> specificity. These diseases include thyroiditis, chronic liver

> >>>>>>> diseases (including primary biliary cirrhosis and chronic

> >>> active

> >>>>>>> Hepatitis), certain cases of pernicious anemia, and myasthenia

> >>>>> gravis.

> >>>>>>> The autoantibodies which appear in these disease states

> >>>>> demonstrate

> >>>>>>> different degrees of specificity with respect to both tissue

> >>> and

> >>>>>>> species. Tissue-specific autoantibodies include those which

> >>> react

> >>>>>>> against erythrocyte stromalantigens, platelets, antihemophilic

> >>>>>>> globulin, thyroid tissue and other tissues, and g-globulin

> >>>>>>> (rheumatoid factor). Autoantibodies without tissue specificity

> >>>>>>> include anti-nuclear, anti-nucleoprotien, anti-DNA, and

> >>>>>>> anti-cytoplasmicantibodies. Autoantibodies directed against

> > the

> >>>>>>> formed elements of the blood can undoubtedly induce disease by

> >>>>>>> causing the destruction and removal of these cells from the

> >>>>>>> circulation. However, it is far less certain whether other

> >>> types

> >>>>> of

> >>>>>>> autoantibodies play pathogenic roles.

> >>>>>>> Most studies of autoantibodies in both humans and animals have

> >>>>>>> concentrated on the reactivity of humoral constituents.

> >>> However,

> >>>>> it

> >>>>>>> should be remembered that the cell-mediated immune response is

> >>> far

> >>>>>>> more efficient in terms of tissue destruction. Since humoral

> >>>>>>> antibodies have been shown, under appropriate circumstances,

> > to

> >>>>>>> prevent cell-mediated tissue damage, it is conceivable that

> >>> they

> >>>>> may

> >>>>>>> have a protective rather than a destructive function. There is

> >>>>>>> presently no indication whether the autoantibodies detected in

> >>>>> human

> >>>>>>> disease rep-resent a primary manifestation of the disease

> >>> itself

> >>>>> or

> >>>>>>> a secondary event stimulated by an underlying, but unrelated,

> >>>>>>> abnormality. In ether event, the mechanisms which may be

> >>>>> responsible

> >>>>>>> for the abrogation of natural immunologic tolerance are worthy

> >>> of

> >>>>>>> consideration. Four general mechanisms have been proposed in

> >>> the

> >>>>>>> pathogenesis of autoantibody production:1.alterations in the

> >>>>>>> structure or distribution of antigens;2.formation of cross-

> >>>>> reactive

> >>>>>>> antibodies following exposure to extrinsic antigens;3.release

> >>> of

> >>>>>>> sequestered antigens; and4.abnormalities of immunologic

> >>> responsive-

> >>>>> ness.

> >>>>>>> An assault on the self through molecular mimicry or antigenic

> >>>>>>> similarity between foreign antigens (virus, bacreria) and

> > human

> >>>>>>> tissue antigens which may end with an autoimmune disease is

> >>>>>>> presented in <<http://www.immuno-sci->http://www.immuno-sci-

> >>>>> lab.com/2003_cat_page27.htm>Fig.

> >>>>>>> 8. This process which may strike many target tissues is shown

> >>> in

> >>>>> Table 1.

> >>>>>>>

> >>>>>>> IMMUNOSCIENCES LAB., INC. - services

> >>>>>>>

> >>>>>>>

> >>>>>>>

> >>>>>>>

> >>>>>>> <<http://www.immuno-sci-lab.com/tests.html>http://www.immuno-

> >>> sci-

> >>>>> lab.com/tests.html>

> >>>>>>> TESTS

> >>>>>>>

> >>>>>>>

> >>>>>>> <<http://www.immuno-sci-lab.com/form.html>http://www.immuno-

> >>> sci-l

> >>>>> ab.com/form.html>

> >>>>>>> FORM

> >>>>>>>

> >>>>>>>

> >>>>>>> <<http://www.immuno-sci-

> >>> lab.com/images/sampleform2.GIF>http://www

> >>>>> .immuno-sci-lab.com/images/sampleform2.GIF>

> >>>>>>> SAMPLE

> >>>>>>>

> >>>>>>>

> >>>>>>>

> >>>>>>>

> >>>>>>> IMMUNOSCIENCES LOGO

> >>>>>>>

> >>>>>>>

> >>>>>>>

> >>>>>>>

> >>>>>>>

> >>>>>>>

> >>>>>>>

> >>>>>>> <<http://promos.hotbar.com/promos/promodll.dll?

> >>>> http://promos.hot

> >>>>> bar.com/promos/promodll.dll?

> >>>>> RunPromo & El= & SG= & RAND=84572 & partner=hbtools>

> >>>>>>> Upgrade Your Email - Click here!

> >>>>>>>

> >>>>>>>

> >>>>>>>

> >>>>>>

> >>>>>

> >>>>>

> >>>>

> >>>

> >>>

> >>>

> >>

> >

> >

> >

>