Guest guest Posted December 15, 2006 Report Share Posted December 15, 2006 Some time back, I read an post that taking statin drugs to lower cholerterol actually was detrimental to MS patients, due to lowering the ability for the brain to produce the necessary cholesteral which repairs the damaged or missing myalin needed to repair MS damage. I seemed to have lost that information, does any body have any information on this? I finally got my cholesteral levels down to normal, but my MS is wreaking havoc with me, kinda a double sword. Quote Link to comment Share on other sites More sharing options...
Guest guest Posted December 16, 2006 Report Share Posted December 16, 2006 Here is an article that talks about some dangers of statins, probably not the one you are referring to but another good reason to not take drugs. *ALS and Statins: an Epidemic? * *by Duane Graveline MD (former NASA Astronaut)* Another case was recently sent to me of amyotrophic lateral sclerosis (ALS) associated with the use of statin drugs. Only a year ago the numbers of case reports of amyotrophic lateral sclerosis reported to me was a trickle - now it is a relative flood. There is not the slightest doubt in my mind that the numbers of reports I am seeing now are far more than usually expected in a group the size of my reporting population. One naturally wonders about this curious relationship with statin drugs and what the possible mechanism of action might be. Recently a neuroscientist, V. Meske, reported in the European Journal of Neuroscience a very relevant study about the ability of statin drugs to cause neuronal degeneration. To refresh your memory statin drugs are designed to inhibit cholesterol synthesis [in the liver] by their effect on the mevalonate pathway. It seems that a consequence of the inhibitory effect of statin drugs on the mevalonate pathway is the induction of abnormal tau protein phosphorylation. Tau protein phosphorylation goes on to form neurofibrillatory tangles, long known to be the prime suspect in causing the slowly progressive neuronal degeneration of Alzheimer’s disease. Sometimes this process is accompanied by Beta amyloid deposition but more commonly not. Research scientists are now finding that this mechanism appears to be true for ALS and many other forms of neurodegenerative diseases as well. They have even coined a new word for this, the taupathies. Dan wrote: >Some time back, I read an post that taking statin drugs to lower >cholerterol actually was detrimental to MS patients, due to lowering >the ability for the brain to produce the necessary cholesteral which >repairs the damaged or missing myalin needed to repair MS damage. I >seemed to have lost that information, does any body have any >information on this? I finally got my cholesteral levels down to >normal, but my MS is wreaking havoc with me, kinda a double sword. > > > > > Quote Link to comment Share on other sites More sharing options...
Guest guest Posted December 17, 2006 Report Share Posted December 17, 2006 Are you taking lots of EFA's? statin drugs Some time back, I read an post that taking statin drugs to lower cholerterol actually was detrimental to MS patients, due to lowering the ability for the brain to produce the necessary cholesteral which repairs the damaged or missing myalin needed to repair MS damage. I seemed to have lost that information, does any body have any information on this? I finally got my cholesteral levels down to normal, but my MS is wreaking havoc with me, kinda a double sword. Quote Link to comment Share on other sites More sharing options...
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