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...My wife has had PLS for over five years and she has been receiving

periodic botox injections for almost as long and they work great. When her

speech is at it's worst, she is at times barely intelligible. It is slurred and

halted and she has trouble forming words. As you know, no two PLS patients are

alike, so I'll share with you her experiences and hope the same holds true for

you.

Her otolaryangologist works in concert with her neurologist to administer the

shot. The area around the Adam's Apple is desensitized and a mico-fine needle

is inserted to probe the area. The neurologist is reading a screen of some type

and giving instructions to his partner. When the affected tissue to located,

the botox is released and needle removed. The entire procedure takes about 20

minutes and is relatively painless. The thought of that it is actually

happening is the most freightening part of the whole thing. Generally, the wait

in the doctor's office is longer than the actual procedure.

Botox is actually botulinum toxin (food poisoning). When administered in a very

minute dose for this purpose, it has a dramtic positive effect on her speech.

Immediately following the injection, her voice becomes very squeaky for a few

days, then breathy. Eventually, within about two weeks, her speech begins to

improve to a point where it's almost normal. It's amazing. The affects of the

shot can last from three to six months depending on the patient. The body

slowly builds up an immunity to the toxin and the procedure needs to be

repeated.

When this was first suggested, we looked at the doctor like he had two heads.

But after some consideration, my wife very bravely decided to give it a try and

we have been thankful ever since. The key to all of this is finding a doctor

who knows what he is doing. We did have an injection administered by a Tampa

physician that failed due to his ineptness. It was terrifying and painful for

her. Fortunately, we have two doctors here in St. sburg who know their

stuff and we are very satified and confident with them. The procedure has

become more and more common over the past few years. It is medically proven and

covered by insurance (at least ours is). Botox is used for a number of medical

procedures from removing crow's feet and age lines, to eliminating muscle

twitching, severe writer's cramps and so on.

Good luck, . I encourage you to move forward with this opportunity.

With all the ailments and symptoms associated with PLS, this is one of the very

few that the patient can actually improve and enjoy quality of life. Let me

hear how it goes. Kind thoughts always...Doug Brand

_______________________________________________________________________________

Subject: botox

From: <PLS-FRIENDSonelist> at ~Internet

Date: 9/16/99 4:13 PM

I would be interested to learn about the experience of others with botox

injections to help with speaking difficulties. This is something recommended by

an otolaryngologist which I am contemplating but haven't tried yet. The botox

actually weakens the vocal chords, alleviating the spasticity, although it may

also create the danger of swallowing difficulties. It won't be a total solution

but it might help. But any help would...well, help.

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Dear PLS ers, I have had over the last four years at least 6 injections of

botox. It has help to speak more clearly and be understood more. I have at

least two per year

the last lasted me a year but I should of done earlier. It takes me about a

month to regain full speaking voice. The first week nothing is noticeable

then the second week just whispers each week its stronger. I do have trouble

with liquids but not soilds foods liquids cause choking but I make a

practice of no liquids while out in public. Believe me it has worked for me

I dont know what I would do without. The first shot you get they give you a

small dose and then you see how long it last the second shot they either

decrease or increase the dose. My husband loves it I cant talk for several

weeks!!! My nero and Ear nose throat Doctor are present along with a tech

that monitores the injection and together they are able to see how close

they are to the vocal chord then when they know that the needle is in the

right spot the botox is injected. Hopes this will you

Flora/St Pete Fla.

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Doug,

I had the botox injection today. I appreciated the encouragement that you

and Flora provided. We will see happens. By the way, do you know the

dosage that she receives? As a first-timer, I got one and a half whatevers.

Jeff

botox

> From: <PLS-FRIENDSonelist> at ~Internet

> Date: 9/16/99 4:13 PM

>

> I would be interested to learn about the experience of others with botox

> injections to help with speaking difficulties. This is something

recommended by

> an otolaryngologist which I am contemplating but haven't tried yet. The

botox

> actually weakens the vocal chords, alleviating the spasticity, although

it may

> also create the danger of swallowing difficulties. It won't be a total

solution

> but it might help. But any help would...well, help.

>

>

>

>

----------------------------------------------------------------------------

----

> <!DOCTYPE HTML PUBLIC " -//W3C//DTD HTML 4.0 Transitional//EN " >

> <HTML><HEAD>

> <META content= " text/html; charset=iso-8859-1 " http-equiv=Content-Type>

> <META content= " MSHTML 5.00.2014.210 " name=GENERATOR>

> <STYLE></STYLE>

> </HEAD>

> <BODY bgColor=#ffffff>

> <DIV><FONT size=2>I would be interested to learn about the experience of

others

> with botox injections to help with speaking difficulties. & nbsp; This is

> something recommended by an otolaryngologist which I am contemplating but

> haven't tried yet. & nbsp; The botox actually weakens the & nbsp; vocal

chords,

> alleviating the spasticity, although it may also create the danger

> of & nbsp;swallowing difficulties. & nbsp; & nbsp;It won't be a total solution

but it

> might & nbsp; help. & nbsp; But & nbsp; any help would...well,

help.</FONT></DIV>

> <DIV> & nbsp;</DIV>

> <DIV><FONT size=2> </FONT></DIV></BODY></HTML>

>

>

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Hi friends:

I am Laurel, age 51, female, and new to PLS. I was diagnosed just about 2

weeks ago. I would like information on lecithin, how much to take,

stretching & exercise, how much to do, and what has helped others to slow

down the progression. I am just so tired most of the time I can hardly

stand myself. I still ambulate fair, with no aids, work full-time, & do all

my own housework, plus help outside with chores and a little gardening. The

only problem with my voice is that I cannot sing very well anymore, and used

to be a soloist until about 2-3 years ago. Plus, my voicebox hurts.

Strange feeling. I have really enjoyed all the comments and emails so far

from PLSPals. I think this support system is really going to help me.

Thanks to all and God bless!

Laurel

Re: botox

>

>

>Doug,

>

>I had the botox injection today. I appreciated the encouragement that you

>and Flora provided. We will see happens. By the way, do you know the

>dosage that she receives? As a first-timer, I got one and a half

whatevers.

>

>Jeff

> botox

>> From: <PLS-FRIENDSonelist> at ~Internet

>> Date: 9/16/99 4:13 PM

>>

>> I would be interested to learn about the experience of others with botox

>> injections to help with speaking difficulties. This is something

>recommended by

>> an otolaryngologist which I am contemplating but haven't tried yet. The

>botox

>> actually weakens the vocal chords, alleviating the spasticity, although

>it may

>> also create the danger of swallowing difficulties. It won't be a total

>solution

>> but it might help. But any help would...well, help.

>>

>>

>>

>>

>

>

>---------------------------------------------------------------------------

-

>----

>

>

>> <!DOCTYPE HTML PUBLIC " -//W3C//DTD HTML 4.0 Transitional//EN " >

>> <HTML><HEAD>

>> <META content= " text/html; charset=iso-8859-1 " http-equiv=Content-Type>

>> <META content= " MSHTML 5.00.2014.210 " name=GENERATOR>

>> <STYLE></STYLE>

>> </HEAD>

>> <BODY bgColor=#ffffff>

>> <DIV><FONT size=2>I would be interested to learn about the experience of

>others

>> with botox injections to help with speaking difficulties. & nbsp; This is

>> something recommended by an otolaryngologist which I am contemplating but

>> haven't tried yet. & nbsp; The botox actually weakens the & nbsp; vocal

>chords,

>> alleviating the spasticity, although it may also create the danger

>> of & nbsp;swallowing difficulties. & nbsp; & nbsp;It won't be a total solution

>but it

>> might & nbsp; help. & nbsp; But & nbsp; any help would...well,

>help.</FONT></DIV>

>> <DIV> & nbsp;</DIV>

>> <DIV><FONT size=2> </FONT></DIV></BODY></HTML>

>>

>>

>

>

>

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Bettie Jo.....Let me give you the " layman's " understanding of what botox does.

My wife has been receiving injections into her vocal cord area for several years

with a high degree of success. Her speech improves dramatically, which of

course, puts her more at ease.

Botox does not cause the muscle to die, but rather " puts it to sleep " for a

period of time. Eventually, the body builds an immunity to the toxin and the

procedure must be repeated. The dosage can last for three to six month or

longer depending on the patient etc. Botox has been used effectively for a

number of reasons. Plastic surgeons use it to eliminate crow's feet and aging

lines around the mouth, eyes and forehead. It also has been used to correct

some forms of facial muscle twitching, severe writer's cramp, spastic gaits etc.

It's apllication does not work for everyone. My wife just happens to be one

that responds favorably to the injections. Perhaps Dr. Bill can be more

specific. In any event, if you are experiencing speech problems associated with

PLS, it would be worthwhile to discuss the possibilites of botox treatments with

your neurologist. If you are a worthy candidate, botox will make all the

difference in the world to you. Good luck and kind thoughts always....Doug

_______________________________________________________________________________

Subject: Botox

From: <PLS-FRIENDSonelist> at ~Internet

Date: 9/23/99 7:16 PM

Dear Bill, MD,

I am confused about something and thought you might be able to set me

straight. I recently read a posting regarding Botox injections. The

writer said that Botox was a protein which was genetically engineered. I

had experience with Botox when I worked as a social worker in a long term

care facility for medically fragile children. Several of our children had

in increased muscle tone and severe contractures. They received Botox

injections to improve range of motion and decrease tightness. I was

informed that Botox was a derivative of botulism toxin, hence the name

Botox. It reportedly worked by causing a small portion of muscle,at the

site of the injection, to die. This produced a decrease in muscle tone

thereby making personal care, range of motion, etc. much easier to provide.

Forgive me imposing on your medical expertise. I would, however, be

mortified if the information we gave to parents was inaccurate.

Thanks, in advance, for any information you can provide.

Take care!

Bettie Jo

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Thanks for the information. When I receive your messages, they are

difficult to read, I am receiving them black print, on dark gray.

Anyone else see it that way, or just me.

Bye!

Love Old#63

aka Rita, Ma, Me

or Auntie Rita

or Grandma

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Unfortunately, I wasn't able to read the article at all... My program

doesn't show the attachment... Can I somehow get a copy, please?

Thank you

Heike from Michigan

*doing the research for her dad*

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