Guest guest Posted December 6, 2006 Report Share Posted December 6, 2006 Hi all. Has anyone experimented with this suppliment by 'organic hope' ? Cheers. Helen x > >Reply-To: mscured >To: mscured >Subject: *MS Article* Molecule Key In MS? >Date: Sun, 03 Dec 2006 23:58:45 -0000 > >Hi > >I only know what is written below. Adam: > >Molecule linked to autoimmune disease relapses identified at Stanford > >Contact: Mitzi Baker >mabaker@... > >Stanford University Medical Center > >Public release date: 3-Dec-2006 > >Contact: Mitzi Baker >mabaker@... > >Stanford University Medical Center > > >STANFORD, Calif. -- The ebb and flow of such autoimmune diseases as >multiple sclerosis, lupus and rheumatoid arthritis has long been a >perplexing mystery. But new findings from the Stanford University School >of Medicine bring scientists closer to solving the puzzle, identifying a >molecule that appears to play a central role in relapses. > >The study, to be published in the Dec. 3 advance online edition of >Nature Immunology, lays the groundwork for a way to determine when a >relapse is about to occur, and could eventually lead to a treatment to >prevent relapses. " Right now, there is no good blood test to evaluate >when a person is going to have a flare-up, " said senior author Larry >Steinman, MD, professor of neurology and neurological sciences. " If we >had one, we might be able to give them prophylactic preventive >medication. " > >The current study had its genesis five years ago: In a paper published >in 2001 in the journal Science, Steinman found that a protein called >osteopontin was abundant in multiple sclerosis-affected brain tissue, >but not in normal tissue. Since then, other groups have confirmed that >osteopontin is elevated just prior to and during a relapse of the >disease in M.S. patients. > >Although the protein had been known to play a role in bone growth, it >was unclear why it would be associated with multiple sclerosis, which >results when the immune system attacks the protective myelin sheath >surrounding nerve cells. > >To explore this question, Eun Mi Hur, PhD, who was then a graduate >student in Steinman's lab, began using a mouse model of multiple >sclerosis (experimental autoimmune encephalomyletis, or EAE) to >investigate how osteopontin could cause these flare-ups. She and >Steinman gave osteopontin to mice that had already experienced >paralysis, similar to that of an M.S. patient, and found that the mice >then experienced a relapse of the disease. > >The researchers also found that the relapse would occur sometimes in an >area of the brain other than the site of the original attack. For >example, after receiving the osteopontin, some animals that had >previously suffered paralysis became blind from a condition called optic >neuritis. One feature of multiple sclerosis is that the flare-ups can >affect different parts of the nervous system at different times. > > " When I saw that all mice with EAE relapsed and died from the disease >after about a month of osteopontin administration, I was surprised, " >said Hur, the study's first author who is now a postdoctoral scholar at >Caltech. " I got a strong belief that a high level of osteopontin in >patients' blood and tissue is a major contributor of the relapse and >progression of the disease. " > >Through the mouse studies and molecular characterizations, Hur and >Steinman showed that osteopontin - produced by immune cells and brain >cells themselves - promotes the survival of the T cells that carry out >the damaging attack on myelin; by increasing the number of these T >cells, osteopontin increases their destructive potential. These results >could be applicable to many other autoimmune diseases, including >rheumatoid arthritis, type-1 diabetes and lupus. > >Indeed, the effect of osteopontin may severely alter the way the immune >system works. Normally, after the immune system does its job - >eradicating a microbe, for instance - the response is then dialed down. >If this didn't happen, the immune response would go on indefinitely. >Imagine a cold or an attack of poison oak that would last forever. > >One of the ways that the immune response is muffled is that the >activated T cells die in a process known as apoptosis. That is precisely >what osteopontin seems to prevent. Osteopontin lets the T cells linger >in the blood, ready to attack again. " We don't know exactly what >triggers that new attack but the cells certainly are around and ready to >do it, " said Steinman. So scientists now face the challenge of figuring >out how and why osteopontin is produced. " We're back to the >chicken-and-the-egg problem, " said Steinman. " We know the egg, so why >did the chicken lay it " That is a trickier problem to work out. " > >Even without knowing the answer to that question, there is one inviting >practical use of their observations: Osteopontin could be used as a >marker of an impending relapse. What's more, if the protein could be >blocked, it might thwart the relapse from ever occurring. Steinman's lab >is working to develop antibodies to inactivate the protein's effect. > " It's still a long road between saying we want to do it and getting the >antibodies, getting it approved by the FDA and getting it tested, " said >Steinman, " but we are determined to do that. " > >Still, Steinman offered a caveat. Researchers may find that blocking >osteopontin has undesirable side effects. The protein may serve other >purposes in addition to promoting survival of immune cells. It could >also be vital to the body's ability to produce myelin, a function that >could cause severe problems if disrupted. " Like a lot of important >biological molecules, osteopontin has a Janus-like quality - a bad side >and a good side, " Steinman said. " We're going to be extremely lucky if >we give the antibody opposing osteopontin and derive just the good side: >We stop the autoimmune attack but don't interfere with the survival of >other cells. " > >Further study will determine whether thwarting osteopontin's effect >yields new types of treatments for autoimmune diseases, but regardless, >it is likely to lead to discoveries in a host of areas. " I think >osteopontin will turn out to be important in a lot of processes, >spanning autoimmunity to stem cells, " said Steinman. " It's probably >going to turn out to be a very basic growth factor. " >### > >EMBARGOED FOR RELEASE UNTIL: Sunday, Dec. 3, 2006, at 11 a.m. to >coincide with advance online publication in Nature Immunology BROADCAST >MEDIA CONTACT: Margarita Gallardo at >(mjgallardo@...) > >This study was supported by the National Institutes of Health, the >National Multiple Sclerosis Society, the Phil N. Trust, a Stanford >Graduate Fellowship, a Korean Government Overseas Scholarship and a >National Multiple Sclerosis Society Career Transitional Award. Other >authors of the study are: Sawsan Youssef, PhD, a postdoctoral scholar in >neurology and neurological sciences; M. Haws, an undergraduate at >Brigham Young University; Zhang, a Stanford undergraduate, and > Sobel, MD, professor of pathology. > >Stanford University Medical Center integrates research, medical >education and patient care at its three institutions - Stanford >University School of Medicine, Stanford Hospital & Clinics and Lucile >Packard Children's Hospital at Stanford. For more information, please >visit the Web site of the medical center's Office of Communication & >Public Affairs at http://mednews.stanford.edu. >http://www.eurekalert.org/pub_releases/2006-12/sumc-mlt120106.php > > _________________________________________________________________ Express yourself instantly with MSN Messenger! Download today it's FREE! http://messenger.msn.click-url.com/go/onm00200471ave/direct/01/ Quote Link to comment Share on other sites More sharing options...
Guest guest Posted December 7, 2006 Report Share Posted December 7, 2006 Hello Helen, My name is . I have used OH Kalawalla for about 6 months. It showed good results, but it did not do what I needed, which was to take away all my ms symptoms. For me, the best approach is not look for a one pill does it all approach. What the rest of the more sr. members of this group have been saying is the route I have decided to take. Meaning, cleansing and then detox (heavy metals and others), raw foods etc.. . > > Hi all. Has anyone experimented with this suppliment by 'organic hope' ? > Cheers. > Helen x > > > > > >Reply-To: mscured > >To: mscured > >Subject: *MS Article* Molecule Key In MS? > >Date: Sun, 03 Dec 2006 23:58:45 -0000 > > > >Hi > > > >I only know what is written below. Adam: > > > >Molecule linked to autoimmune disease relapses identified at Stanford > > > >Contact: Mitzi Baker > >mabaker@ > > > >Stanford University Medical Center > > > >Public release date: 3-Dec-2006 > > > >Contact: Mitzi Baker > >mabaker@ > > > >Stanford University Medical Center > > > > > >STANFORD, Calif. -- The ebb and flow of such autoimmune diseases as > >multiple sclerosis, lupus and rheumatoid arthritis has long been a > >perplexing mystery. But new findings from the Stanford University School > >of Medicine bring scientists closer to solving the puzzle, identifying a > >molecule that appears to play a central role in relapses. > > > >The study, to be published in the Dec. 3 advance online edition of > >Nature Immunology, lays the groundwork for a way to determine when a > >relapse is about to occur, and could eventually lead to a treatment to > >prevent relapses. " Right now, there is no good blood test to evaluate > >when a person is going to have a flare-up, " said senior author Larry > >Steinman, MD, professor of neurology and neurological sciences. " If we > >had one, we might be able to give them prophylactic preventive > >medication. " > > > >The current study had its genesis five years ago: In a paper published > >in 2001 in the journal Science, Steinman found that a protein called > >osteopontin was abundant in multiple sclerosis-affected brain tissue, > >but not in normal tissue. Since then, other groups have confirmed that > >osteopontin is elevated just prior to and during a relapse of the > >disease in M.S. patients. > > > >Although the protein had been known to play a role in bone growth, it > >was unclear why it would be associated with multiple sclerosis, which > >results when the immune system attacks the protective myelin sheath > >surrounding nerve cells. > > > >To explore this question, Eun Mi Hur, PhD, who was then a graduate > >student in Steinman's lab, began using a mouse model of multiple > >sclerosis (experimental autoimmune encephalomyletis, or EAE) to > >investigate how osteopontin could cause these flare-ups. She and > >Steinman gave osteopontin to mice that had already experienced > >paralysis, similar to that of an M.S. patient, and found that the mice > >then experienced a relapse of the disease. > > > >The researchers also found that the relapse would occur sometimes in an > >area of the brain other than the site of the original attack. For > >example, after receiving the osteopontin, some animals that had > >previously suffered paralysis became blind from a condition called optic > >neuritis. One feature of multiple sclerosis is that the flare-ups can > >affect different parts of the nervous system at different times. > > > > " When I saw that all mice with EAE relapsed and died from the disease > >after about a month of osteopontin administration, I was surprised, " > >said Hur, the study's first author who is now a postdoctoral scholar at > >Caltech. " I got a strong belief that a high level of osteopontin in > >patients' blood and tissue is a major contributor of the relapse and > >progression of the disease. " > > > >Through the mouse studies and molecular characterizations, Hur and > >Steinman showed that osteopontin - produced by immune cells and brain > >cells themselves - promotes the survival of the T cells that carry out > >the damaging attack on myelin; by increasing the number of these T > >cells, osteopontin increases their destructive potential. These results > >could be applicable to many other autoimmune diseases, including > >rheumatoid arthritis, type-1 diabetes and lupus. > > > >Indeed, the effect of osteopontin may severely alter the way the immune > >system works. Normally, after the immune system does its job - > >eradicating a microbe, for instance - the response is then dialed down. > >If this didn't happen, the immune response would go on indefinitely. > >Imagine a cold or an attack of poison oak that would last forever. > > > >One of the ways that the immune response is muffled is that the > >activated T cells die in a process known as apoptosis. That is precisely > >what osteopontin seems to prevent. Osteopontin lets the T cells linger > >in the blood, ready to attack again. " We don't know exactly what > >triggers that new attack but the cells certainly are around and ready to > >do it, " said Steinman. So scientists now face the challenge of figuring > >out how and why osteopontin is produced. " We're back to the > >chicken-and-the-egg problem, " said Steinman. " We know the egg, so why > >did the chicken lay it " That is a trickier problem to work out. " > > > >Even without knowing the answer to that question, there is one inviting > >practical use of their observations: Osteopontin could be used as a > >marker of an impending relapse. What's more, if the protein could be > >blocked, it might thwart the relapse from ever occurring. Steinman's lab > >is working to develop antibodies to inactivate the protein's effect. > > " It's still a long road between saying we want to do it and getting the > >antibodies, getting it approved by the FDA and getting it tested, " said > >Steinman, " but we are determined to do that. " > > > >Still, Steinman offered a caveat. Researchers may find that blocking > >osteopontin has undesirable side effects. The protein may serve other > >purposes in addition to promoting survival of immune cells. It could > >also be vital to the body's ability to produce myelin, a function that > >could cause severe problems if disrupted. " Like a lot of important > >biological molecules, osteopontin has a Janus-like quality - a bad side > >and a good side, " Steinman said. " We're going to be extremely lucky if > >we give the antibody opposing osteopontin and derive just the good side: > >We stop the autoimmune attack but don't interfere with the survival of > >other cells. " > > > >Further study will determine whether thwarting osteopontin's effect > >yields new types of treatments for autoimmune diseases, but regardless, > >it is likely to lead to discoveries in a host of areas. " I think > >osteopontin will turn out to be important in a lot of processes, > >spanning autoimmunity to stem cells, " said Steinman. " It's probably > >going to turn out to be a very basic growth factor. " > >### > > > >EMBARGOED FOR RELEASE UNTIL: Sunday, Dec. 3, 2006, at 11 a.m. to > >coincide with advance online publication in Nature Immunology BROADCAST > >MEDIA CONTACT: Margarita Gallardo at > >(mjgallardo@) > > > >This study was supported by the National Institutes of Health, the > >National Multiple Sclerosis Society, the Phil N. Trust, a Stanford > >Graduate Fellowship, a Korean Government Overseas Scholarship and a > >National Multiple Sclerosis Society Career Transitional Award. Other > >authors of the study are: Sawsan Youssef, PhD, a postdoctoral scholar in > >neurology and neurological sciences; M. Haws, an undergraduate at > >Brigham Young University; Zhang, a Stanford undergraduate, and > > Sobel, MD, professor of pathology. > > > >Stanford University Medical Center integrates research, medical > >education and patient care at its three institutions - Stanford > >University School of Medicine, Stanford Hospital & Clinics and Lucile > >Packard Children's Hospital at Stanford. For more information, please > >visit the Web site of the medical center's Office of Communication & > >Public Affairs at http://mednews.stanford.edu. > >http://www.eurekalert.org/pub_releases/2006-12/sumc-mlt120106.php > > > > > > _________________________________________________________________ > Express yourself instantly with MSN Messenger! Download today it's FREE! > http://messenger.msn.click-url.com/go/onm00200471ave/direct/01/ > Quote Link to comment Share on other sites More sharing options...
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