RE: Prostate Cancer Not Linked To Sex Hormones

[Guest guest]

No that is not what it says in the

abstract. This has nothing to do with people who have prostate cancer.

Hormones as a cancer treatment are used to lower testosterone, etc. once cancer

begins to grow but what it does say is that testosterone, etc. levels are not

responsible for cancer beginning.

Hormone therapy has been shown to extend

life for men with PCa.

Kathy

From: ProstateCancerSupport [mailto:ProstateCancerSupport ] On Behalf Of shedorman@...

Sent: Friday, February 01, 2008

7:33 AM

To: ProstateCancerSupport

Subject: Re:

Prostate Cancer Not Linked To Sex Hormones

Kathy

Are you saying that Hormonal Therapy does not stop the spread of

prostate cancer or shrink the prostate?

Sheila

-------------- Original message --------------

From: " Kathy Meade " <kmeadelistaec225>

http://www.medicalnewstoday.com/articles/95662.php

According to a

pooled analysis of 18 prior studies, sex hormones in the bloodstream appear not

to be linked to prostate

cancer

risk. The researchers found no association between circulating levels of

different forms of testosterone or estrogen and prostate

cancer

risk.

The analysis is published in a new study in the 29th January issue of the Journal of the National Cancer

Institute and was conducted by Dr And rew Roddam of the University

of Oxford, England, UK and colleagues at the Endogenous Hormones and Prostate

Cancer

Collaborative Group.

There have been nearly two dozen studies on the link between circulating levels

of androgens or sex hormones, and the risk of prostate

cancer,

but on the whole the results are inconsistent, said the researchers.

Roddam and colleagues analyzed pooled results from 18 studies that between them

covered existing worldwide epidemiologic data about the relationship between

serum (blood) levels of sex hormones and prostate

cancer.

The data included 3,886 men who had prostate

cancer

and 6,438 men who did not (controls).

The results showed:

No links between risk of prostate

cancer

and serum levels of testosterone, calculated free testosterone,

dihydrotestosterone, dehydroepiandrosterone sulfate,

androstenedione, androstanediol glucuronide, estradiol, or calculated free

estradiol.

Serum levels of sex hormone-binding

globulin were " modestly inversely associated with prostate

cancer

risk " .

There was no statistical evidence of

heterogeneity among the studies and adjustment for potential confounders

made little significant difference to the results (both of which

strengthen the case for the findings of this study).

The

researchers concluded that:

" In this collaborative analysis of the worldwide data on endogenous

hormones and prostate

cancer

risk, serum concentrations of sex hormones were not associated with the risk of

prostate

cancer. "