Anti-PR3 and Anti-MPO IgG ANCA in Autistic Children With Chronic GI Disease

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Anti-PR3 and Anti-MPO IgG ANCA in Autistic Children With Chronic GI Disease

A.J. Russo, A Krigsman, B Jepson and Wakefield

Immunology and Immunogenetics Insights 2009:2 21--28

Aim: To assess both ant-PR3 and anti-MPO IgG anti-neutrophil cytoplasmic

antibodies (ANCA), in autistic children with gastrointestinal symptoms

and controls, and to test the hypothesis that there is an association

between the presence of these antibodies and infl ammatory GI disease

seen in many autistic children.

Subjects and Methods: ELISA's were used to measure anti-PR3 and anti-MPO

IgG in 40 autistic children with chronic digestive disease (many with

ileo-colonic lymphoid nodular hyperplasia (LNH) and infl ammation of the

colorectum, small bowel and/or stomach), and 41 controls (21 age matched

autistic children with no GI disease and 20 age matched children without

autism or GI disease).

Results: Six of 40 autistic children with chronic digestive disease had

anti-PR3 antibodies compared to none of the 41 controls (p 0.01).

Thirteen of the 40 autistic children with chronic digestive disease had

anti-MPO IgG compared to only 3 (1 autistic control with no GI disease

and 2 non-autistic controls without GI disease) of 41 controls (p

0.001). All six of those with anti-PR3 IgG also had anti-MPO antibodies.

These results suggest a relationship between individuals with ANCA and

severity of intestinal disease in a subset.

Discussion: These results suggest an association between anti-PR3 and

anti-MPO antibodies and a subset of ASD children with GI infl ammation.

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