Antiherpetic flavonoids against herpes simplex viruses HSV-1 and HSV-2

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Antiherpetic activities of flavonoids against herpes simplex virus type

1 (HSV-1) and type 2 (HSV-2) in vitro.

Lyu SY, Rhim JY, Park WB.

Arch Pharm Res. 2005 Nov;28(11):1293-301.

Immune Modulation Research Group, The School of Pharmacy

Univ of Nottingham, Univ Park, Nottingham, NG7 2RD, UK.

http://tinyurl.com/d3oe2v

Flavonoids, a group of low molecular weight phenylbenzopyrones, have

various pharmacological properties including antioxidant, anticancer,

bactericidal, and anti-inflammatory. We carried out anti-herpetic assays

on 18 flavonoids in five classes and a virus-induced cytopathic effect

(CPE) inhibitory assay, plaque reduction assay, and yield reduction

assay were performed. When flavonoids were applied at various

concentrations to Vero cells infected by HSV-1 and 2, most of the

flavonoids showed inhibitory effects on virus-induced CPE. Among the

flavonoids, EC, ECG (flavanols), genistein (isoflavone), naringenin

(flavanone), and quercetin (flavonol) showed a high level of CPE

inhibitory activity. The antiviral activity of flavonoids were also

examined by a plaque reduction assay. EC, ECG, galangin, and kaempferol

showed a strong antiviral activity, and catechin, EGC, EGCG, naringenin,

chrysin, baicalin, fisetin, myricetin, quercetin, and genistein showed

moderate inhibitory effects against HSV-1. In these experiments,

flavanols and flavonols appeared to be more active than flavones.

Furthermore, treatment of Vero cells with ECG and galangin (which

previously showed strong antiviral activities) before virus adsorption

led to a slight enhancement of inhibition as determined by a yield

reduction assay, indicating that an intracellular effect may also be

involved.

PMID: 16350858

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