Guest guest Posted December 16, 2007 Report Share Posted December 16, 2007 > Does anyone know if there is a direct relationship between DHT levels > and PC? Also, levels of DHT when you have PC? Yes there is. It is well-known that testosterone (T) nourishes PCa cells. Dihydrotestosterone (DHT) is a metabolite of T and is several times as potent as T. There is extensive information on DHT on the authoritative and encyclopedic website of the Prostate Cancer Research Institute (PCRI) at: http://prostate-cancer.org/index.html A quote from one article: > T is carried into the prostate cell and interacts with the androgen > receptor (AR) within the nucleus of the cell. T is also converted to > dihydrotestosterone (DHT), a metabolite that is five times as potent > as T in its effects on prostate cell growth. Other authors hold that it is even more potent. " Normal " range for DHT is 25 - 75 ng/dL. When treating for PCa, the less the better. It is controlled by Proscar or Avodart. Regards, Steve J Quote Link to comment Share on other sites More sharing options...
Guest guest Posted December 16, 2007 Report Share Posted December 16, 2007 Although this doesn't specifically address a direct relationship between " DHT " lvels and PC nor levels of DHT when you have PC, the below URL explains a trial where a high ratio of estramustine-binding protein (EMBP) to dihydrotestosterone (DHT) could determine low progression-free probability compared to those with low ratios, and concludes " The androgen-dependent property of EMBP tends to decline with the transformation of prostatic tissue into biologically more malignant disease. The tissue EMBP:DHT ratio before treatment may be a good indicator of the individual malignant potential of PCs. " http://tinyurl.com/2pom4w Other that this ratio correlation between EMBP and DHT to identify cancer that is likely more aggressive, it is recognized that reducing the DHT level of men with prostate cancer is important to reining in PC progression. This is usually accomplished with 5AR inhibitors dutasteride/Avodart or finasteride/Proscar. > > Does anyone know if there is a direct relationship between DHT levels > and PC? Also, levels of DHT when you have PC? Steve > Quote Link to comment Share on other sites More sharing options...
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