MS Article

[Guest guest]

A New Line Of Communication Between Nervous System Cells Discovered By

Weizmann Scientists

Main Category: Neurology / Neuroscience News

Article Date: 30 Jun 2007 - 13:00 PDT

In a host of neurological diseases, including multiple sclerosis (MS)

and several neuropathies, the protective covering surrounding the

nerves - an insulating material called myelin - is damaged. Scientists

at the Weizmann Institute of Science have now discovered an important

new line of communication between nervous system cells that is crucial

to the development of myelinated nerves - a discovery that may aid in

restoring the normal function of the affected nerve fibers.

Nerve cells (neurons) have long, thin extensions called axons that can

reach up to a meter and or more in length. Often, these extensions are

covered by myelin, which is formed by a group of specialized cells

called glia. Glial cells revolve around the axon, laying down the

myelin sheath in segments, leaving small nodes of exposed nerve in

between. More than just protection for the delicate axons, the myelin

covering allows nerve signals to jump instantaneously between nodes,

making the transfer of these signals quick and efficient. When myelin

is missing or damaged, the nerve signals can't skip properly down the

axons, leading to abnormal function of the affected nerve and often to

its degeneration.

In research published recently in Nature Neuroscience, Weizmann

Institute scientists Prof. Elior Peles, graduate student Ivo Spiegel,

and their colleagues in the Molecular Cell Biology Department and in

the United States, have now provided a vital insight into the

mechanism by which glial cells recognize and myelinate axons.

How do the glial cells and the axon coordinate this process " The

Weizmann Institute team found a pair of proteins that pass messages

from axons to glial cells. These proteins, called Necl1 and Necl4,

belong to a larger family of cell adhesion molecules, so called

because they sit on the outer membranes of cells and help them to

stick together. Peles and his team discovered that even when removed

from their cells, Necl1, normally found on the axon surface, and

Necl4, which is found on the glial cell membrane, adhere tightly

together. When these molecules are in their natural places, they not

only create physical contact between axon and glial cell, but also

serve to transfer signals to the cell interior, initiating changes

needed to undertake myelination.

The scientists found that production of Necl4 in the glial cells rises

when they come into close contact with an unmyelinated axon, and as

the process of myelination begins. They observed that if Necl4 is

absent in the glial cells, or if they blocked the attachment of Necl4

to Necl1, the axons that were contacted by glial cells did not

myelinate. In the same time period, myelin wrapping was already well

underway around most of the axons in the control group.

" What we've discovered is a completely new means of communication

between these nervous system cells, " says Peles. " The drugs now used

to treat MS and other degenerative diseases in which myelin is

affected can only slow the disease, but not stop or cure it. Today, we

can't reverse the nerve damage caused by these disorders. But if we

can understand the mechanisms that control the process of wrapping the

axons by their protective sheath, we might be able to recreate that

process in patients. "

###

http://www.medicalnewstoday.com/medicalnews.php?newsid=75315 & nfid=rssfeeds

[Guest guest]

Well said! There are so many people just waiting for miracle cures

from toxic drugs when the answer is to give your body the nutrition it

needs and in time it will heal itself!! I don't let any toxic drug to

pass my lips and that also would include LDN.

Gill (UK)

rich perillo wrote:

>

> All very impressive retoric, but I do'nt see anything in referance to

Toxins " the cause " , or nutrients " to repair " is never there. It's the

same with cancer research for the past 60 years, we're so close, all we

need is more money, and nothing changes. We're made out of nutrients

but thats not what they [research]. Can't patent nutrients. No big

profits.........RP

[Guest guest]

Hi Gill,

I take LDN. What proof do you have that it is toxic?

Regards,

Dudley Delany

http://profiles.yahoo.com/dudley_delany

[Guest guest]

Hi Rich,

Do you have proof that LDN is toxic?

Regards,

Dudley Delany

http://profiles.yahoo.com/dudley_delany

[Guest guest]

And I agree with you Gill, for the most part, regarding drugs. But I would

recommend LDN in " low dose " if it is helpfull. ....RP

Gill Butts wrote: Well said! There are so many

people just waiting for miracle cures

from toxic drugs when the answer is to give your body the nutrition it

needs and in time it will heal itself!! I don't let any toxic drug to

pass my lips and that also would include LDN.

Gill (UK)

rich perillo wrote:

>

> All very impressive retoric, but I do'nt see anything in referance to

Toxins " the cause " , or nutrients " to repair " is never there. It's the

same with cancer research for the past 60 years, we're so close, all we

need is more money, and nothing changes. We're made out of nutrients

but thats not what they [research]. Can't patent nutrients. No big

profits.........RP

---------------------------------

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[Guest guest]

Hi Nina,

LDN stands for " Low Dose Naltrexone. " For more information about LDN,

visit

http://tinyurl.com/2boot2

All the best,

Dudley Delany

http://profiles.yahoo.com/dudley_delany

[Guest guest]

Good morning Dudley, I do'nt have any proof myself, but the manufacturer of

Naltrexone warns, do not take it if you have liver disease, and it can cause

vomiting, joint,muscle and stomach pain, nausea, fatigue, nervousness, headach

and so on. But the normal dose I believe is 150mg for a different condition. I

am not opposed to 'low dose'. ....RP

DudleyDelany@... wrote:

Hi Rich,

Do you have proof that LDN is toxic?

Regards,

Dudley Delany

http://profiles.yahoo.com/dudley_delany

---------------------------------

Get the free Yahoo! toolbar and rest assured with the added security of spyware

protection.

[Guest guest]

Thanks, very much, Dudley! :-)

Nina

DudleyDelany@... wrote:

Hi Nina,

LDN stands for " Low Dose Naltrexone. " For more information about LDN,

visit

http://tinyurl.com/2boot2

All the best,

Dudley Delany

http://profiles.yahoo.com/dudley_delany

---------------------------------

Get your own web address.

Have a HUGE year through Yahoo! Small Business.

[Guest guest]

Hi Rich,

The normal dose of Naltrexone is 50 mg daily. It is the dose considered

" safe " by the FDA. The dose recommended for MS is less than one tenth of

that and is generally considered nontoxic.

Dudley

[Guest guest]

You're very welcome, Nina. Glad to be of service!

Dudley

http://profiles.yahoo.com/dudley_delany

[Guest guest]

Thank you Dudley, the normal dose is 50mg a day. The PDR says you can take 150mg

every three days if you wish. That is NOT the dose for M/S you all. ....RP

DudleyDelany@... wrote:

Hi Rich,

The normal dose of Naltrexone is 50 mg daily. It is the dose considered

" safe " by the FDA. The dose recommended for MS is less than one tenth of

that and is generally considered nontoxic.

Dudley

---------------------------------

Got a little couch potato?

Check out fun summer activities for kids.

[Guest guest]

Thanks for this information. I hope there continues to be studies of how to live

with or how to cure MS and I appreciate reading of these studies. Whether I use

any of these cures is my decision in the end but I am glad people are looking.

MS Article

A New Line Of Communication Between Nervous System Cells Discovered

By

Weizmann Scientists

Main Category: Neurology / Neuroscience News

Article Date: 30 Jun 2007 - 13:00 PDT

In a host of neurological diseases, including multiple sclerosis (MS)

and several neuropathies, the protective covering surrounding the

nerves - an insulating material called myelin - is damaged. Scientists

at the Weizmann Institute of Science have now discovered an important

new line of communication between nervous system cells that is crucial

to the development of myelinated nerves - a discovery that may aid in

restoring the normal function of the affected nerve fibers.

Nerve cells (neurons) have long, thin extensions called axons that can

reach up to a meter and or more in length. Often, these extensions are

covered by myelin, which is formed by a group of specialized cells

called glia. Glial cells revolve around the axon, laying down the

myelin sheath in segments, leaving small nodes of exposed nerve in

between. More than just protection for the delicate axons, the myelin

covering allows nerve signals to jump instantaneously between nodes,

making the transfer of these signals quick and efficient. When myelin

is missing or damaged, the nerve signals can't skip properly down the

axons, leading to abnormal function of the affected nerve and often to

its degeneration.

In research published recently in Nature Neuroscience, Weizmann

Institute scientists Prof. Elior Peles, graduate student Ivo Spiegel,

and their colleagues in the Molecular Cell Biology Department and in

the United States, have now provided a vital insight into the

mechanism by which glial cells recognize and myelinate axons.

How do the glial cells and the axon coordinate this process " The

Weizmann Institute team found a pair of proteins that pass messages

from axons to glial cells. These proteins, called Necl1 and Necl4,

belong to a larger family of cell adhesion molecules, so called

because they sit on the outer membranes of cells and help them to

stick together. Peles and his team discovered that even when removed

from their cells, Necl1, normally found on the axon surface, and

Necl4, which is found on the glial cell membrane, adhere tightly

together. When these molecules are in their natural places, they not

only create physical contact between axon and glial cell, but also

serve to transfer signals to the cell interior, initiating changes

needed to undertake myelination.

The scientists found that production of Necl4 in the glial cells rises

when they come into close contact with an unmyelinated axon, and as

the process of myelination begins. They observed that if Necl4 is

absent in the glial cells, or if they blocked the attachment of Necl4

to Necl1, the axons that were contacted by glial cells did not

myelinate. In the same time period, myelin wrapping was already well

underway around most of the axons in the control group.

" What we've discovered is a completely new means of communication

between these nervous system cells, " says Peles. " The drugs now used

to treat MS and other degenerative diseases in which myelin is

affected can only slow the disease, but not stop or cure it. Today, we

can't reverse the nerve damage caused by these disorders. But if we

can understand the mechanisms that control the process of wrapping the

axons by their protective sheath, we might be able to recreate that

process in patients. "

###

http://www.medicaln ewstoday. com/medicalnews. php?newsid= 75315 & nfid= rssfeeds

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[Guest guest]

My understanding is that any medication is not natural and not good for

the liver. However, in dealing with MS, one must weigh the risks and

benefits of various treatments. I would prefer to be on no meds, but I

do take LDN to help control the disease progression. If I ever feel I

have cured my MS, I will stop the LDN.

>

> Good morning Dudley, I do'nt have any proof myself, but the

manufacturer of Naltrexone warns, do not take it if you have liver

disease, and it can cause vomiting, joint,muscle and stomach pain,