Alteration of body total antioxidant capacity and thiol molecules in human chronic exposure to aluminum

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" Supplementation of workers with antioxidants may have beneficial effects. "

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Alteration of body total antioxidant capacity and thiol molecules in

human chronic exposure to aluminum

Akram Ranjbar et al

Toxicological & Environmental Chemistry, Volume 90, Issue 4 July 2008 ,

pages 707 - 713

http://tinyurl.com/57vljo

The physiological role of aluminum (Al) is not yet known. Exposure to Al

may cause many human disorders. The aim of this study was to explore how

occupational human exposure to Al might affect the body oxidative

stress. The relation between Al toxicity and oxidative stress was

studied in blood samples obtained from 45 primary Al production workers,

with a minimum work history of three years in the age range of 29-52

years. They were evaluated for oxidative stress biomarkers including

thiobarbituric acid reactive substances (TBARS) indicator of lipid

peroxidation, ferric reducing ability of plasma (FRAP) indicator of

total antioxidant capacity, total thiol molecules and Al level in blood.

The results showed that workers have significantly higher blood Al

levels and concomitant lower blood FRAP and total thiol molecules in

comparison to controls. Smokers had lower total thiol molecules than

non-smokers. The subjects who had a previous history of disease had

lower FRAP levels. It is concluded that Al induces oxidative stress in

primary Al production workers. Supplementation of workers with

antioxidants may have beneficial effects.

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