Re: something to watch for

[Guest guest]

Hi,

Even though at work, I just did some research ... but keep in mind that

anything that currently says naproxen is in a different form of delivery -

like oral pills, which are ingested, whereas this new stuff will be topical

cream, which *I* would think would have much lower systemic absorption than

would taking this stuff orally.

So, I don't know what the topical cream will do ... sounds like a topical

kind of pain reliever? Not sure - but certainly something to look for, as

it is being developed FOR vulvar vestibulitis.

Anyhow - it isn't a steroid, as Judy said ... and for those of you

interested here is some more information I found:

Healing thoughts to you all,

-

naproxen is in a class of drugs called nonsteroidal anti-inflammatory drugs

(NSAIDs).

naproxenPRONUNCIATION:na PROX en

BRAND:Aleve, Aleve Caplet, Anaprox, Anaprox-DS, EC Naprosyn, Naprelan,

Naprosyn

naproxen works by reducing hormones that cause inflammation and pain in the

body. naproxen is used to reduce pain, inflammation, and stiffness caused by

many conditions, such as osteoarthritis, rheumatoid arthritis, gout,

ankylosing spondylitis, injury, abdominal cramps associated with

menstruation, tendinitis, and bursitis

naproxen may also be used for purposes other than those listed in this

medication guide.

naproxen is in the FDA pregnancy category B. This means that it is unlikely

to harm an unborn baby. naproxen should not be taken late in pregnancy (the

third trimester) because a similar drug is known to affect the baby's heart.

Do not take naproxen without first talking to your doctor if you are

pregnant.

naproxen passes into breast milk and may harm a nursing infant. Do not take

this medicine without first talking to your doctor if you are breast-feeding

a baby.

Other prescription and over-the-counter drugs may increase the effects of

naproxen and cause dangerous side effects. Tell your doctor if you are

taking any of the following drugs:

other nonsteroidal anti-inflammatory drugs (NSAIDs) such as ibuprofen

(Motrin, Rufen, others), ketoprofen (Orudis, Orudis KT, Oruvail);

other commonly used NSAIDs, including diclofenac (Voltaren, Cataflam),

etodolac (Lodine), fenoprofen (Nalfon), flurbiprofen (Ansaid), indomethacin

(Indocin), ketorolac (Toradol), nabumetone (Relafen), oxaprozin (Daypro),

piroxicam (Feldene), sulindac (Clinoril), or tolmetin (Tolectin);aspirin and

other salicylates (forms of aspirin) such as salsalate (Disalcid), choline

salicylate, and magnesium salicylate (watch the aspirin content of other

over-the-counter products such as cough, cold, and allergy medicines);

diuretics (water pills) such as hydrochlorothiazide (HCTZ, Hydrodiuril,

others), chlorothiazide (Diuril, others), chlorthalidone (Thalitone),

bumetanide (Bumex), ethacrynic acid (Edecrin), furosemide (Lasix),

spironolactone (Aldactone), and amiloride (Midamor);anticoagulants such as

warfarin (Coumadin);steroids such as prednisone (Deltasone);alcohol;oral

antidiabetic drugs such as glipizide (Glucotrol) and glyburide (Micronase,

Diabeta);lithium (Eskalith, Lithobid, others);cyclosporine (Sandimmune,

Neoral); orbismuth subsalicylate in drugs such as Pepto-Bismol.

BUT - remember - these are warnings for naproxen in the form of orally

ingested pills - not a topical cream

Your pharmacist has additional information about naproxen written for health

professionals that you may read.

Naproxen

http://www.infomed.org/100drugs/napfram.html

Naproxen: Indications

----------------------------------------------------------------------------

----

In many studies naproxen proved to be equally as effective as other

non-steroidal anti-inflammatory agents (e.g. diclofenac, piroxicam). Its

symptomatic action is particularly suited for rheumatic ailments. Its

effects on arthroses and chronic polyarthritis have been examined most

thoroughly. Subjects with ankylosing spondylitis (Bechterew's disease),

juvenile arthritis, gout seizures, or soft tissue rheumatism can also be

treated with naproxen. Naproxen's relatively long duration of action is

thereby often considered an advantage.

The drug has also been tested for several pain states of non-rheumatic

origin. It is equal to other analgesics for postoperative and posttraumatic

pain and for dysmenorrhea. The drug can reduce blood loss caused by

menorrhagia in women with an intrauterine contraceptive device. Naproxen can

be used for tension headaches and it has been used as an antipyretic agent

(especially in children). It can also reduce tumour induced fever.

Naproxen also has good efficacy for migraine attacks. However, it is not

clearly established if it is also suitable for migraine prophylaxis.

Non-steroidal anti-inflammatory agents are tolerated very differently from

individual to individual; it is therefore important to know several of these

drugs well. Naproxen is a reliable antirheumatic agent with average side

effects. Its effect (without slow release) lasts at least half a day, which

can often be advantageous. It is a pity that naproxen is so expensive in

Switzerland.

Naproxen: Pharmacology

Naproxen is a propionic acid derivative whose structure and effect are

related to ibuprofen. These anti-inflammatory agents also have analgesic and

antipyretic action. Like other non-steroidal anti-inflammatory agents

naproxen inhibits prostaglandin synthesis.

Naproxen: Adverse Reactions

The most common adverse reactions are gastrointestinal pains (heartburn,

abdominal pain, nausea, constipation, all occur in more than 5% of the

treated subjects). Central nervous problems such as headaches, somnolence,

tinnitus, vertigo, as well as edemas and respiratory problems are not

uncommon either.

Skin rashes, pruritus, diarrhea, insomnia, depressions, myalgias, etc. are

not observed very frequently with naproxen.

Dangerous side effects (gastrointestinal bleedings or perforations, acute

interstitial nephritis, hepatitis, blood production disorders) are rare.

Naproxen: Interactions

Like other anti-inflammatory agents, naproxen can impair the hypotensive

effect of antihypertensive agents and it can increase the toxicity of

methotrexate. Naproxen can also cause the rise of lithium levels. On the

other hand, probenecid significantly prolongs the half life of naproxen.

Despite the fact that it can inhibit platelet aggregation, naproxen can be

combined with anticoagulants (if monitored carefully).

Naproxen: Contraindications

So-called aspirin intolerance. Active peptic ulcer. Advanced renal failure.

Naproxen: Cautions

Smoking is likely to favour the development of gastrointestinal ulcers.

Naproxen: Risk Groups

Pregnant women: Can be given during the first two trimesters. Avoid in the

third trimester (premature closure of the duct of Botallo is possible).

Nursing mothers: Only small amounts can be traced in breast milk. Can be

taken.

Children: Children's dose: twice daily 2.5 to a maximum of 7.5 mg/kg. Avoid

in children under two years (not enough documentation).

Elderly people: Risks with non-steroidal anti-inflammatory agents are

greater in high age. Start with half doses!

Renal failure: Usually no adjustment necessary. Half dose when creatinine

clearance is less than 15 ml/minute.

Liver insufficiency: Signifcant increase of free plasma concentration of

naproxen, a dose reduction is therefore indicated.

http://www.rxlist.com/cgi/generic/naprox.htm

DESCRIPTION

Naproxen tablets for oral administration each contain 250 mg, 375 mg or 500

mg of naproxen. Naproxen suspension for oral administration contains 125

mg/5 ml of naproxen. Naproxen is a member of the arylacetic acid group of

nonsteroidal anti-inflammatory drugs.

The chemical name for naproxen is 2-naphthaleneacetic acid, 5 methoxy-

a-methyl-,(+).

Naproxen is an odorless, white to off-white crystalline substance. It is

lipid soluble, practically insoluble in water at low pH and freely soluble

in water at high pH.

Naproxen suspension for oral administration contains 125 mg/5 ml of

naproxen, the active ingredient, in a vehicle of FD & C yellow #6, fumaric

acid, imitation orange flavor, imitation pineapple flavor, magnesium

aluminum silicate, methyl paraben, purified water, sodium chloride, sorbitol

solution and sucrose.

CATEGORIES, BRAND NAMES

CATEGORIES: Ankylosing spondylitis; Arthritis, gouty; Arthritis, juvenile;

Arthritis, osteoarthritis; Arthritis, rheumatoid; Bursitis; Dysmenorrhea;

Pain, mild to moderate; Tendonitis; Pregnancy Category B; FDA Approved 1982

Apr; Top 200 Drugs

FDA Drug Classes: Analgesics, General; Analgesics-Non-Narcotic;

Antiarthritics; Antigout; NSAID

BRAND NAMES:

BRAND NAMES: Acusprain; Anaprox; Anax; Anexopen; Antalgin; Apo-Napro-NA;

Apo-Naproxen; Apranax; Apronax; Artagen; Arthrisil; Artrixen; Artroxen;

Atiflan; Bipronyl; Bonyl; Clinosyn; Congex; Dafloxen; Danaprox; Daprox;

Diocodal; Duk; Dysmenalgit; EC-Naprosyn; Ec-Naprosyn; Femex; Flanax; Flanax

Forte; Flexen; Flexin; Flexipen; Floginax; Fuxen; Genoxen; Gibixen; Headlon;

Inza; Laraflex; Laser; Lefaine; Leniartil; Nafasol; Naixan; Nalyxan;

Napflam; Napmel; Naposin; Napoton; Napren; Naprium; Naprius; Naprogesic;

Naprontag; Naprorex; Naprosyn; Naprosyn LLE; Naprosyn LLE Forte; Naprosyne;

Naproxi 250; Naproxi 500; Naprux; Napxen; Narma; Narocin; Naxen; Naxen F;

Naxid; Naxopren; Naxyn 250; Naxyn 500; Noflam; Norswel; Novonaprox;

Nycopren; Patxen; Prafena; Prexan; Priaxen; Primeral; Prodexin; Pronaxen;

Proxen; Proxen LE; Proxen LLE; Rahsen; Rheumaflex; Roxen; Saritilron;

Sinartrin; Sinton; Soproxen; Sutolin; Sutony; Synflex; Tohexen; Traumox;

U-Ritis; Velsay; Veradol; Vinsen; Xenar; Xenobid

(Foreign Brand names outside U.S. in italics)

FOREIGN BRAND AVAILABILITY:

Acusprain (South-Africa)

Anaprox (Australia; Korea; Taiwan)

Anax (Korea)

Anexopen (Greece)

Antalgin (Spain)

Apo-Napro-NA (Canada)

Apo-Naproxen (Canada; Israel; New-Zealand)

Apranax (Bahrain; Belgium; Bulgaria; Costa-Rica; Cyprus; Dominican-Republic;

Egypt; El-Salvador; France; Germany; Guatemala; Honduras; Iran; Iraq;

Israel; Jordan; Kuwait; Lebanon; Libya; Nicaragua; Oman; Panama; Qatar;

Republic-Of-Yemen; Saudi-Arabia; Switzerland; Syria; United-Arab-Emirates)

Apronax (Colombia)

Artagen (India)

Arthrisil (Thailand)

Artroxen (Italy)

Atiflan (Mexico)

Bipronyl (Malaysia)

Bonyl (Denmark)

Clinosyn (South-Africa)

Congex (Argentina)

Dafloxen (Mexico)

Danaprox (Indonesia)

Daprox (Denmark)

Diocodal (Argentina)

Duk (Colombia)

Dysmenalgit (Germany)

Femex (Netherlands)

Flanax (Brazil; Costa-Rica; Dominican-Republic; El-Salvador; Guatemala;

Honduras; Mexico; Nicaragua; Panama; Philippines)

Flanax Forte (Philippines)

Flexen (Taiwan)

Flexin (Thailand)

Floginax (Italy)

Fuxen (Mexico)

Genoxen (Hong-Kong)

Gibixen (Italy)

Headlon (Japan)

Inza (Australia; Hong-Kong)

Laraflex (England)

Laser (Italy)

Lefaine (Philippines)

Leniartil (Italy)

Nafasol (South-Africa)

Naixan (Japan)

Nalyxan (India)

Napflam (South-Africa)

Napmel (Hong-Kong; Malaysia)

Naposin (Taiwan)

Naprium (Bahrain; Benin; Burkina-Faso; Cyprus; Egypt; Ethiopia; Gambia;

Ghana; Guinea; Iran; Iraq; Israel; Ivory-Coast; Jordan; Kenya; Kuwait;

Lebanon; Liberia; Libya; Malawi; Mali; Mauritania; Mauritius; Morocco;

Niger; Nigeria; Oman; Qatar; Republic-Of-Yemen; Saudi-Arabia; Senegal;

Seychelles; Sierra-Leone; South-Africa; Sudan; Syria; Tanzania; Tunia;

Uganda; United-Arab-Emirates; Zambia; Zimbabwe)

Naprius (Italy)

Naprogesic (Australia; New-Zealand)

Naprontag (Argentina)

Naprorex (Bahrain; Cyprus; Egypt; Iran; Iraq; Israel; Jordan; Kuwait;

Lebanon; Libya; Oman; Qatar; Republic-Of-Yemen; Saudi-Arabia; Syria;

United-Arab-Emirates)

Naprosyn LLE (Philippines)

Naprosyn LLE Forte (Philippines)

Naprosyne (Belgium; France; Netherlands)

Naproxi 250 (Israel)

Naproxi 500 (Israel)

Naprux (Argentina)

Napxen (Thailand)

Narma (Japan)

Narocin (Israel)

Naxen (Canada; Indonesia; Mexico; South-Africa; Taiwan)

Naxen F (Korea)

Naxid (India)

Naxopren (Finland)

Naxyn 250 (Israel)

Naxyn 500 (Israel)

Noflam (New-Zealand)

Norswel (Benin; Burkina-Faso; Ethiopia; Gambia; Ghana; Guinea; Ivory-Coast;

Kenya; Liberia; Malawi; Mali; Mauritania; Mauritius; Morocco; Niger;

Nigeria; Senegal; Seychelles; Sierra-Leone; South-Africa; Sudan; Tanzania;

Tunia; Uganda; Zambia; Zimbabwe)

Novonaprox (Canada)

Nycopren (Denmark; Finland)

Patxen (Mexico)

Prafena (Indonesia)

Prexan (Italy)

Priaxen (Bahamas; Barbados; Belize; Benin; Bermuda; Burkina-Faso; Curacao;

Ethiopia; Gambia; Ghana; Guinea; Guyana; Ivory-Coast; Jamaica; Kenya;

Liberia; Malawi; Mali; Mauritania; Mauritius; Morocco; Netherland-Antilles;

Niger; Nigeria; Puerto-Rico; Senegal; Seychelles; Sierra-Leone;

South-Africa; Sudan; Surinam; Tanzania; Trinidad; Tunia; Uganda; Zambia;

Zimbabwe)

Primeral (Italy)

Prodexin (Bahrain; Cyprus; Egypt; Iran; Iraq; Israel; Jordan; Kuwait;

Lebanon; Libya; Oman; Qatar; Republic-Of-Yemen; Saudi-Arabia; Syria;

United-Arab-Emirates)

Pronaxen (Sweden)

Proxen (Austria; Bahrain; Cyprus; Egypt; Germany; Iran; Iraq; Israel;

Jordan; Kuwait; Lebanon; Libya; Oman; Qatar; Republic-Of-Yemen;

Saudi-Arabia; Spain; Switzerland; Syria; United-Arab-Emirates)

Proxen LE (South-Africa)

Proxen LLE (Taiwan)

Rahsen (Japan)

Rheumaflex (Malaysia)

Roxen (Thailand)

Saritilron (Japan)

Sinartrin (Peru)

Soproxen (Malaysia)

Sutolin (Taiwan)

Synflex (Australia; England; Hong-Kong; Indonesia; Malaysia; New-Zealand)

Tohexen (Japan)

Traumox (South-Africa)

U-Ritis (Taiwan)

Velsay (Mexico)

Veradol (Argentina)

Vinsen (Thailand)

Xenar (Italy)

Xenobid (India)

COST OF THERAPY: 88.69 (Arthritis; Tablet; 250 mg; 2/day; 365 days)

NAPROXEN-SODIUM (~this is Anaprox~)

Common uses : This medicine is used to relieve pain, swelling, menstrual

pain; reduce fever; and other uses as determined by your doctor.

[Guest guest]

Naproxen is an NSAID, (ibuprofen is another one).

Aleve is Naproxen. It is available in tablets, capsules and suspension. I

could not find anything about a cream.

Ora

On Fri, 30 Mar 2001 09:00:43 -0500, Genzlinger

wrote:

>Hi Everyone,

>

>I am not at liberty to say where I got this information, or too much about

>it.

>But please keep your eye out for a topical cream with generic name Naproxen.

>

>It is in clinical trials in the UK and I think in the US as well.

>

>It is in the works for a VV " treatment " and development actually began a few

>years ago,

>but just recently a change to the chemical structure was made,

>and I am not sure what that does to the time of its release.

>

>Does anyone know what naproxen is?

>I will be very disappointed if it turns out to be a steroid.

>

>But we should all keep a watch out for it, especially those of you in

>England,

>as you might hear about it first.

>

>Just wanted to give this info to all of you.

>-

>

[Guest guest]

Ora wrote:

<I could not find anything about a cream.>

Thanks for your research and for the information, that is basically what I

have found, as well.

I found nothing on a cream either, but I don't think is " out there " yet for

us to find ... as what I shared with all of you is actually privileged

info, not really for, or known, by the general public ...

I just wanted everyone to keep an eye out for the release of the cream form

of it, we need all the info we can get, right? And, it is being developed

for VV, and is only in clinical trials at this point, and I actually don't

know an estimated time of release....

-

[Guest guest]

I found the following information regarding NSAID creams. Naproxen is an NSAID

drug.

Ora

http://www.ucprx.com/pain_relief.html

Non-Steroidal Anti-Inflammatory Drugs (NSAIDs) are the most commonly

prescribed medications for

pain. They relieve pain in the majority of patients, but do have side effects

that often limit their use.

Stomach upset, gastritis, and even ulcers are possible with long term oral

NSAID use. There is,

however, a therapeutic alternative to oral NSAIDs.

University Compounding Pharmacy (UCP) pharmacists have developed a variety of

NSAID creams.

These creams require a prescription specifically written for a patient and

each product is individually

prepared for the patient.

For a personal consultation with a Pharmacist regarding these creams, just

E-mail UCP.

The following are answers to some of UCP's most commonly asked questions.

1.Q Should I be concerned about stomach upset with NSAID creams?

A. No. Since less than 3% of the drug is absorbed by the body, there is

less potential for side

effects like stomach upset and gastritis.

2. Q. How often are these creams applied and how much should be used?

A. The usual amount needed to treat pain and inflammation is about 1/4

teaspoonful - or

enough to cover the affected area. Generally, three times daily is sufficient to

relieve pain

and reduce inflammation.

3. Q. What NSAIDs are available in a transdermal cream?

A. Practically all. The most popularly prescribed NSAID creams that

UCP makes are

Ketoprofen, Naproxen, Ibuprofen, Piroxicam, Indomethacin, and Diclofenac.

4. Q. Can other drugs be added to the NSAID cream?

A. Yes. For example, muscle relaxers for muscle strain; neuroleptics

for nerve pain; other

analgesics for increased pain relief; and local anesthetic agents.

5. Q. How much do these transdermal creams cost?

A. The average cost is less than $1.00 per day.

6. Q. Are these transdermal NSAID creams covered by my health insurance?

A. In many cases, yes. Many insurance companies, HMO's, etc., cover

these creams. And

Workman's Compensation Insurance will pay the entire cost as well.

7.Q. If transdermal NSAIDs are so great, why aren't they commercially

available from

drug companies?

A. Because these drugs are off patent. No drug manufacturer is

motivated to invest millions

of dollars to develop a product without patent and profit protection.

How to order:

NSAID transdermal creams require a prescription from a U.S. licensed doctor.

Fax the prescription

plus your completed Print Order Form as instructed on the order form.

Order by E-mail:

Now you can click here to go to the On-Line-Order Form

Methods of payment:

UCP accepts Visa, MasterCard, Discover, American Express, and personal checks

(checks,

however, are subject to a 10 day hold.) The price varies according to

quantity. Shipping is free to

any address in the U.S.A.

Want to know more about what UCP can do for you? Click Here

Copyright ©1999 University Compounding Pharmacy

[Guest guest]

I found another website on this subject which says essentially the same thing.

It is at:

http://www.itcpharmacy.com/ITCTimes1.html

Ora

[Guest guest]

Strange, I used to take Naproxen under the brand name of Anaprox all

the time for the horrible menstrual cramps I used to get. Anaprox was

the only thing that would work for me at the time and prevent me from

throwing up from the pain. It used to make me feel kind of high in a

spaced out, warm and happy way. I always thought they were a muscle

relaxer. Thanks for all the research you did. Now I know what I was

actually taking.

Ainsley

> Hi,

> Even though at work, I just did some research ... but keep in mind

that

> anything that currently says naproxen is in a different form of

delivery -

> like oral pills, which are ingested, whereas this new stuff will be

topical