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Re: pulse/Val estradiol

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If you are not low, I wonder why you would have the problems you are

mentioning? The receptors in the urinary tract and vaginal tract are very

sensitive to lack of hormones. In fact, if I get the problem you are

describing, which often comes with a urinary tract infection but not always,

I used a bit of estradiol gel and it works immediately.

I do not use it often since I am like you, I don't want to mess with

anything I may not really need. Low testosterone also causes this and when

I used test. creme, the problem cleared up. BUT, I get headaches with test.

replacement so I just use the estradiol gel when I get the symptoms of

dryness. I may use estradiol once a week. I use as little as possible of

all the hormones.

How is your progesterone and testosterone levels?

-- Re: pulse

>>Natural estradiol gel works wonders for that as does progesterone. But the

estradiol will clear that up almost immediately!<<

BUT I am not low in estrogen. NORMAL levels for post meno, why screw that

up?

--

Artistic Grooming- Hurricane WV

My Ebay Jewelry Store http://stores.ebay.com/valeriescrystalcreations

http://www.stopthethyroidmadness.com/

http://health.groups.yahoo.com/group/NaturalThyroidHormonesADRENALS/

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<<If you are not low, I wonder why you would have the problems you are

mentioning? The receptors in the urinary tract and vaginal tract are very

sensitive to lack of hormones. In fact, if I get the problem you are

describing, which often comes with a urinary tract infection but not always,

I used a bit of estradiol gel and it works immediately.

How is your progesterone and testosterone levels?>>

-------Original Message-------

Val wrote: <<BUT I am not low in estrogen. NORMAL levels for post

meno, why screw that up?>>

Val --

I completely agree with . Even if your systemic levels of estradiol

really are adequate, it is VERY common for there to still be a local

deficiency in the vulvar and bladder tissues. There are tons of estradiol

receptors in those tissues; and if local levels are deficient and/or estrogen

receptors are shut down, it can easily lead to vestibular, vaginal and

bladder tissue thinning, tearing, dryness, pain, and atrophy.

Topical bio-identical estradiol (usually in conjunction with topical

testosterone), works extremely well to keeps these tissues plump,

healthy, and moist. It also helps maintain the proper acidic vaginal

pH of about 4.5, which cuts down on the increase in bladder infections

that women often experience post-menopause. Some surgeons

actually use estradiol in preparation for vaginal/vestibular operations

since it provides such excellent tissue support, as well as being superb,

after the fact, for wound healing.

Of course, being unpatentable, bio-identicals are not exactly top

priority for the pharmaceutical companies, although they have actually

managed to produce a few bio-identical alternatives for vaginal dryness/

atrophy, such as Estrace. It will be interesting to see how the drug

that you're having a part in testing pans out. Maybe i'll be proved wrong,

but my feeling is that it's yet another case of creating a drug for big

profit

when bio-identical would do a much better job for this specific problem.

(I realize, though, after looking at some of the info on the clinical trial,

that there are other functions that they're investigating, not just vaginal

atrophy.)

There have been studies that show that there is very little systemic

absorption of estradiol when it's used on/in the vulva/vestibule. Of course,

used vaginally it WOULD raise systemic estradiol levels to some degree.

But that's not necessarily a bad thing. Some people argue that women

continue to produce estrogen after menopause and, therefore, don't need

any supplementation. But the estrogen they're producing is primarily estrone,

which, without been balanced by the other two main estrogens --estradiol,

the " mother " estrogen and estriol -- HAS been linked with breast cancer.

And i have to add that " normal " lab values for post-menopausal estradiol

are pretty much along the same lines as what is usually considered " normal "

thyroid levels: far from adequate. My latest lab report lists the low end

of the

" normal " post-menopausal estradiol range as 5 pg/ml. This is simply

ludicrous.

For most women of ANY age, pre- OR post-menopausal, any estradiol level

under about 90 -100 will be inadequate for providing fully all of its

important

benefits to heart, brain, bones, skin, muscles, libido, etc. etc. So, a

person

can easily be told they're " normal, " and still be quite deficient.

Hollis

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For some reason, this message never appeared. . .so i'm reposting it.

If everyone else who gets individual messages DID receive it, my apologies!

Hollis

<<If you are not low, I wonder why you would have the problems you are

mentioning? The receptors in the urinary tract and vaginal tract are very

sensitive to lack of hormones. In fact, if I get the problem you are

describing, which often comes with a urinary tract infection but not always,

I used a bit of estradiol gel and it works immediately.

How is your progesterone and testosterone levels?>>

-------Original Message-------

Val wrote: <<BUT I am not low in estrogen. NORMAL levels for post

meno, why screw that up?>>

Val --

I completely agree with . Even if your systemic levels of estradiol

really are adequate, it is VERY common for there to still be a local

deficiency in the vulvar and bladder tissues. There are tons of estradiol

receptors in those tissues; and if local levels are deficient and/or estrogen

receptors are shut down, it can easily lead to vestibular, vaginal and

bladder tissue thinning, tearing, dryness, pain, and atrophy.

Topical bio-identical estradiol (usually in conjunction with topical

testosterone), works extremely well to keeps these tissues plump,

healthy, and moist. It also helps maintain the proper acidic vaginal

pH of about 4.5, which cuts down on the increase in bladder infections

that women often experience post-menopause. Some surgeons

actually use estradiol in preparation for vaginal/vestibular operations

since it provides such excellent tissue support, as well as being superb,

after the fact, for wound healing.

Of course, being unpatentable, bio-identicals are not exactly top

priority for the pharmaceutical companies, although they have actually

managed to produce a few bio-identical alternatives for vaginal dryness/

atrophy, such as Estrace. It will be interesting to see how the drug

that you're having a part in testing pans out. Maybe i'll be proved wrong,

but my feeling is that it's yet another case of creating a drug for big

profit

when bio-identical would do a much better job for this specific problem.

(I realize, though, after looking at some of the info on the clinical trial,

that there are other functions that they're investigating, not just vaginal

atrophy.)

There have been studies that show that there is very little systemic

absorption of estradiol when it's used on/in the vulva/vestibule. Of course,

used vaginally it WOULD raise systemic estradiol levels to some degree.

But that's not necessarily a bad thing. Some people argue that women

continue to produce estrogen after menopause and, therefore, don't need

any supplementation. But the estrogen they're producing is primarily estrone,

which, without been balanced by the other two main estrogens --estradiol,

the " mother " estrogen and estriol -- HAS been linked with breast cancer.

And i have to add that " normal " lab values for post-menopausal estradiol

are pretty much along the same lines as what is usually considered " normal "

thyroid levels: far from adequate. My latest lab report lists the low end

of the

" normal " post-menopausal estradiol range as 5 pg/ml. This is simply

ludicrous.

For most women of ANY age, pre- OR post-menopausal, any estradiol level

under about 90 -100 will be inadequate for providing fully all of its

important

benefits to heart, brain, bones, skin, muscles, libido, etc. etc. So, a

person

can easily be told they're " normal, " and still be quite deficient.

Hollis

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I also experienced hot flashes when I used estrogen. So now I cut the dose

way back and put it on a couple times the day I use it, or else just use a

little bit. It is probably from a lot being absorbed at one time and then

when it is used up, you are low.

I was prescribed the Prometrium pills which is natural progesterone in pill

form. It is released more steadily, supposedly. It can also be used

vaginally and my doc prefers that. However, I was not impressed with the

pills in relation to the expense.

-- Re: pulse/Val estradiol

When I use Oestrogel now I end up with immediate hot flashes the next

three days and night sweas thta night. OS a non hormonal solution seems

like a greta thing to me, and this opend estrogen receptors, which is

how it works. So what estrogen you have works better for releiving these

symptoms. I do nto want high estrogen as it binds thyroid hormone sand I

certainyl don't want to mess wiht thta! LOL

--

Artistic Grooming- Hurricane WV

My Ebay Jewelry Store http://stores.ebay.com/valeriescrystalcreations

http://www.stopthethyroidmadness.com/

http://health.groups.yahoo.com/group/NaturalThyroidHormonesADRENALS/

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Val:

What do you mean " opened receptors " .

I read that the phytoestrogens bind with the estrogen receptors more

readily than the body's own estrogen. This causes the phytoestrogens to

replace estrogen and actually make you lower in estrogen. I would only want

that if I had an estrogen-dependent cancer.

-- Re: pulse/Val estradiol

When I use Oestrogel now I end up with immediate hot flashes the next

three days and night sweas thta night. OS a non hormonal solution seems

like a greta thing to me, and this opend estrogen receptors, which is

how it works. So what estrogen you have works better for releiving these

symptoms. I do nto want high estrogen as it binds thyroid hormone sand I

certainyl don't want to mess wiht thta! LOL

--

Artistic Grooming- Hurricane WV

My Ebay Jewelry Store http://stores.ebay.com/valeriescrystalcreations

http://www.stopthethyroidmadness.com/

http://health.groups.yahoo.com/group/NaturalThyroidHormonesADRENALS/

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In a message dated 9/22/2006 8:25:38 AM Eastern Daylight Time,

linnmiller@... writes:

>

> Prometrium is a synthetic progesterone.

>

>

>

,

Technically, Linn is right: Bio-identical does not always equal

" natural " -- as in naturally occuring in nature. Prometrium

IS synthetic, made in a lab. But, while it's not " natural, " the

end result IS bio-identical to the hormone that the body

naturally produces. The semantics of differentiating between

the terms " synthetic, " " natural, " and " bio-identical " can get

very confusing! For example, Premarin, derived from mare's

urine is completely " natural, " but certainly NOT bio-identical

to any hormone a female human produces.

" Progesterone USP is a chemical molecule made in the laboratory

to be IDENTICAL in all respects to the natural hormone made

by the ovary. It begins as building blocks found in soybeans

and wild yams (diogenin, diascorea, and others); it is then

purified and processed through a series of chemical changes

that require enymes we don't have in our bodies. It has been

available in injectable form since the 1940's and is now available

as a tablet (Prometrium) or vaginal gel (Crinone). Progesterone

USP is also used by compounding pharmacists to make

individualized prescriptions in many forms, including tablets,

supppositories, and creams. Because it is identical to the

natural molecule, many women find that it has fewer unplesant

side effects than progestins [which are also synthetic, but not

at all bio-identical] such as Provera. "

Dr. L. Vliet

It's My Ovaries, Stupid!

p. 27

Hollis

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Nope Prometrium is not bio-identical, I looked up the chemical make-

up for someone on the adeno group who was looking for info on it.

Linn

> Hi Linn, maybe you're thinking of Progestin? That's

> synthetic. Prometrium is natural.

>

>

>

> --- Linn wrote:

>

> > Prometrium is a synthetic progesterone.

> >

> > Linn

>

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I would like to see what you looked up. Would you mind posting the link?

Thanks.

-- Re: pulse/Val estradiol

Nope Prometrium is not bio-identical, I looked up the chemical make-

up for someone on the adeno group who was looking for info on it.

Linn

> Hi Linn, maybe you're thinking of Progestin? That's

> synthetic. Prometrium is natural.

>

>

>

> --- Linn wrote:

>

> > Prometrium is a synthetic progesterone.

> >

> > Linn

>

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It was the usual fine print from the drug manufacturer itself. I

don't have the reference handy, but you should be able to google

Prometrium and get all the fine print including the chemical make-up,

side effects, etc.

Linn

On Sep 22, 2006, at 12:45 PM, C. Mannelli, Ed.D. wrote:

> I would like to see what you looked up. Would you mind posting the

> link?

>

> Thanks.

>

> -------Original Message-------

>

> .

>

>

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It says Prometrium capsules is structurally identical to the

progesterone naturally produced in a woman's body. The progesterone

in Prometrium capsules is synthesized from yams.

This is also my understanding of bioidentical.

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I think it's more common with PMS for it to be a progesterone allergy.

Not estrone. I see an allergist for progesterone allergy and it

appears to be common. More common than we know. In fact, we can be

allergic to any one of our hormones.

I take sublingual dilutions of weak progesterone under the tongue to

" reset " my brain's reaction to P. I have major toxic reactions to P

that got worse during peri. As I adjust to the dose of antigen in my

sublingual I move up to the next strength. It's mixed to parts per

thousand. Here is a link of the doc I see who treats me:

http://www.onlineallergycenter.com/hormoneallergies/

As I develop allergy symptoms I know to drop down in sublingual dose to

" correct " the symptoms. It's very cool. Homeopathic even. You can

test to see exactly which hormones you are overly sensitive to.

AG

> Posted by: " C. Mannelli, Ed.D. " smann  

> guiltedgirls

>

> Hollis:

>

> My doc also told me that after menopause when estrone is mainly

> produced, a

> woman can have an allergic reaction to it. Have you ever heard of

> this? My

> doc used to be the director of an allergy clinic. I think he also

> said that

> during PMS, estrone is elevated causing the allergic rx commonly

> thought to

> be PMS.

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In a message dated 9/23/2006 4:56:51 AM Eastern Daylight Time,

smann writes:

> My doc also told me that after menopause when estrone is mainly produced, a

> woman can have an allergic reaction to it. Have you ever heard of this? My

> doc used to be the director of an allergy clinic. I think he also said that

> during PMS, estrone is elevated causing the allergic rx commonly thought to

> be PMS.

>

> I probably don't have all of this story correct but that is the gist of it.

>

>

>

>

No, i haven't heard about allergies to estrone, but it makes sense, since

it's certainly possible to have allergic reactions to one's own hormones.

Your doctor's comment about estrone elevation being responsible for

PMS symptoms is a new one on me. In my case, i strongly feel it's

the rise in P in the luteal phase (and my P is definitely elevated) that

creates the bloating, fatigue, breast pain, etc. But for those who

blame estrogen, then i guess it might be a possibility. I've never had

my estrone or estriol tested, just estradiol.

Hollis

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