Re: More on phenergan request

February 7, 2011

lori

thiank yuou that was what the dcotor called it,Â Â i havent had any other

episodes of it since thephergan adn every tiem i treid to zke even a partila

odse i still got the tardive ........ so i threw out all my pheregan ias much as

i hate throwing up and i do often with my kidney issues i hated the side effects

worse.Â thanks an dhugs sharon

>

>Hi, all. I've " lurked " on this board for several years. My mother's neurologist

says her dementia is " more like Alzheimers " than LBD, but based on many, many

symptoms I've been inclined to think she has LBD (I'd never even heard of it,

but it was suggested after a neuropsych evaluation -- in particular because of

her history of falls) . Up to now, the precise diagnosis hasn't mattered.

Aricept gave her diarrhea, and she has been on Namenda for two years. But no

other meds have been suggested that are on the LBD danger list. (She has only

mild and non-frightening hallucinations.) She has lived alone, with increasing

help from me (just a few miles away).

>

>However, she had a stroke on January 23, and was transferred to Rehab/Nursing

Home on the 31st. I told the nurse during admission that she may have LBD. Today

I got a call saying she vomited today (MIGHT have caught a bug from my sister

before my sister knew she had a bug), and the doctor had ordered phergan if it

happened again. I just told them she might have had a problem with phergan once

before, and asked them not to give it to her until I got back to them. Meanwhile

I couldn't find anything quickly on this board or the lbda site, but knew I'd

get the best information from all of you.

>

>Is phergan something I have to be worried about?

>

>Thanks much! Regards,

>

> Hosey

>

February 7, 2011

Looks like a good one to avoid, especially with the association with neuroleptic

malignant syndrome.

http://en.wikipedia.org/wiki/Promethazine

Promethazine is a first-generation H

<http://en.wikipedia.org/wiki/Histamine_H1_receptor> 1 receptor antagonist of

the phenothiazine <http://en.wikipedia.org/wiki/Phenothiazine> chemical

<http://en.wikipedia.org/wiki/Chemical_class> class used medically as an

antihistamine <http://en.wikipedia.org/wiki/Antihistamine> antiemetic

<http://en.wikipedia.org/wiki/Antiemetic> . It has a strong sedative

<http://en.wikipedia.org/wiki/Sedative> effect and in some countries is

prescribed for insomnia when benzodiazepines

<http://en.wikipedia.org/wiki/Benzodiazepines> are contraindicated. It is

available over the counter <http://en.wikipedia.org/wiki/Over-the-counter_drug>

in the United <http://en.wikipedia.org/wiki/United_Kingdom> Kingdom, Australia

<http://en.wikipedia.org/wiki/Australia> , Switzerland

<http://en.wikipedia.org/wiki/Switzerland> , and many other countries, but by

prescription in the United <http://en.wikipedia.org/wiki/United_States> States

(brand names Phenergan, Promethegan, Romergan, Fargan, Farganesse, Prothiazine,

Avomine, Atosil, Receptozine, Lergigan).[1]

<http://en.wikipedia.org/wiki/Promethazine#cite_note-rxlisttabone-0>

Promethazine is a phenothiazine derivative that competitively and potently

blocks histamine H1 receptors without blocking the secretion of histamine. It

also is a moderate muscarinic acetylcholine

<http://en.wikipedia.org/wiki/Muscarinic_antagonist> antagonist and a very weak

dopamine antagonist.[6] <http://en.wikipedia.org/wiki/Promethazine#cite_note-5>

[7] <http://en.wikipedia.org/wiki/Promethazine#cite_note-6>

Some common side effects

<http://en.wikipedia.org/wiki/Adverse_effect_%28medicine%29> include:

* Confusion in the elderly

* Drowsiness, dizziness, fatigue, more rarely vertigo

<http://en.wikipedia.org/wiki/Vertigo_%28medical%29>

* Dry mouth

* Respiratory <http://en.wikipedia.org/wiki/Hypoventilation> depression in

patients under age of 2 and in those with severely compromised pulmonal function

* Constipation

* Chest Discomfort/Pressure. (typically in cases when patient is already taking

medication for high blood pressure)

* Euphoria (very rare, except with high IV doses and/or coadministration with

opioids/CNS depressants)

* Restless legs [8] <http://en.wikipedia.org/wiki/Promethazine#cite_note-7>

* Paresthesia <http://en.wikipedia.org/wiki/Paresthesia>

* Short temper/Irritability

Extremely rare side effects include:

* Seizures <http://en.wikipedia.org/wiki/Seizures>

* Neuroleptic malignant syndrome

<http://en.wikipedia.org/wiki/Neuroleptic_malignant_syndrome>

Because of potential for more severe side effects, this drug is on the list to

avoid in the elderly. (See NCQAâ€™s HEDIS Measure: Use

<http://www.ncqa.org/Portals/0/Newsroom/SOHC/Drugs_Avoided_Elderly.pdf> of High

Risk Medications in the Elderly).

From: LBDcaregivers [mailto:LBDcaregivers ] On

Behalf Of Lori

Sent: Sunday, February 06, 2011 9:01 PM

To: LBDcaregivers

Subject: Re: More on phenergan request

Hi Sharon,

Sounds like you had an extreme case of tardive dyskinesia, a reaction that is

listed as a possible side effect of phenergan as well as certain other

medications.

Some med mixes can do that as well, but phenergan can do it on its own.

Lori

Re: More on phenergan request

gina

i have lbd, and my opimon on phenergan is NO NO NONONONONONONNO

ok , why,

i took phenergan for years adn out of the blue, when i was hospitalized two

years i had phenergan for extreme n/v assoc iwth my kidney infection. all of a

sudden i statred having uncontrollable reflex movements. my knee/leg jerked so

hard that i kicked a full food tray compltely across the room , and it was on my

tray .

my neck had it worse i would have jerks and my head would stay natled almost

laying on my shoulder and HURT BAD. ones neck is not meant to be resting on your

own shoulder,

my arms would jerk so ad that i poked myself in the eye several times.

we immediately stopped phenergan and the symptoms went away,

me being the disbeliever i am thought it was asociated with the other meds i was

getting in the hosptial and i had another bout of n/v and took 1/2 of a tablet

to test it out, well later taht nite my poor adooorable boogie was sleeping next

to me sound asleep snoring contently chasing rabbits in his dreams **he was a 10

lb yorkishire terrier who since died* my foot jerked so hard taht i kicked him

out of the bed and he flew across the room about 4 ft high poor thing wasnt hurt

seriously bu ti learned then i t was hte phergan for sure.

i have had sucess with zofran and compazine, so far at least.

good luck and hugs. sharon