Guest guest Posted May 9, 2001 Report Share Posted May 9, 2001 What is Substance P? If you have links that will tell me I would love to look them up. Bunny ----Original Message Follows---- Reply-To: VulvarDisorders To: <VulvarDisorders > Subject: Substance P, & glands Date: Tue, 8 May 2001 23:38:18 -0400 Doesn't substance P, simply show up if there's sufficient inflammation and pain? If so, then it 'would' show up in the VV glands, but not be any type of disease per se', but maybe all else was no different? In other words even a wound from an arm biopsied from a cut might show the same thing? Just thinking out loud here and have no idea but what I thought and could be totally wrong. Warmest, Dee~ _________________________________________________________________ Get your FREE download of MSN Explorer at http://explorer.msn.com Quote Link to comment Share on other sites More sharing options...
Guest guest Posted May 9, 2001 Report Share Posted May 9, 2001 Hi All, Substance P is released by your nerve cells that send pain information back to your central nervous system. It doesn't really care why your having pain your body just reacts that way when it hurts. Dee is absolutely right in her reasoning that it can be just as prevalent in your cut arm as any place else. The real problem with all the extra substance P found in our vulvas is there is usually no reason for it to be there. Only lots of unspecified inflammation. I don't doubt any tissues removed from anyone with vulvodynia or vulva vestibulitis has lots of inflammation along with substance P, mast cells and histamines! (along with about 4 other things doctors don't seem to mention) Inflammation really is not the problem with our vulvas. (although it hurts!) The problem is finding out what is causing the inflammation and stopping it. It took me years to figure out why my vulva was 5 times it's regular size. That's the problem...finding out why. Until then, ice :-) Blessings, Shirley. PS I think the studies about tissue and glands could be two different things. Tissue removed is not nessarily glands. It can be but may not. Both studies could be correct. Biopsies can be very spicific. Quote Link to comment Share on other sites More sharing options...
Guest guest Posted May 9, 2001 Report Share Posted May 9, 2001 > What is Substance P? > > If you have links that will tell me I would love to look them up. > > Bunny Dear , Substance P is a neuropeptide that is really a reaction to irritation, disease or trauma by neurons. It's what people are trying to stop from being produced when they put capsicum on their vulvas. Capsicum has something in it called an enkephalin that suppresses the production of substance P. It's also a neuropeptide and is thought to be stronger than morphine at relieving pain. This is all I know about these substances. I'm sure you can do a search on any of these and find lots more info on them. Perhaps Dee knows where to look. I bet she does :-) Blessings, Shirley. Quote Link to comment Share on other sites More sharing options...
Guest guest Posted May 9, 2001 Report Share Posted May 9, 2001 Is it true that part of the reason anti-depressants can help is that serotonin reduces Substance P? Alison Quote Link to comment Share on other sites More sharing options...
Guest guest Posted May 9, 2001 Report Share Posted May 9, 2001 Thank you shirly, that was really helpful. I am guessing that this plays a role in the pain loop that the doctors give us antidepressents for (with me it is zoloft, I've done Elivil too). Bunny ----Original Message Follows---- Reply-To: VulvarDisorders To: <VulvarDisorders > Subject: Re: Substance P, & glands Date: Wed, 9 May 2001 00:46:24 -0500 Hi All, Substance P is released by your nerve cells that send pain information back to your central nervous system. It doesn't really care why your having pain your body just reacts that way when it hurts. Dee is absolutely right in her reasoning that it can be just as prevalent in your cut arm as any place else. The real problem with all the extra substance P found in our vulvas is there is usually no reason for it to be there. Only lots of unspecified inflammation. I don't doubt any tissues removed from anyone with vulvodynia or vulva vestibulitis has lots of inflammation along with substance P, mast cells and histamines! (along with about 4 other things doctors don't seem to mention) Inflammation really is not the problem with our vulvas. (although it hurts!) The problem is finding out what is causing the inflammation and stopping it. It took me years to figure out why my vulva was 5 times it's regular size. That's the problem...finding out why. Until then, ice :-) Blessings, Shirley. PS I think the studies about tissue and glands could be two different things. Tissue removed is not nessarily glands. It can be but may not. Both studies could be correct. Biopsies can be very spicific. _________________________________________________________________ Get your FREE download of MSN Explorer at http://explorer.msn.com Quote Link to comment Share on other sites More sharing options...
Guest guest Posted May 9, 2001 Report Share Posted May 9, 2001 I have heard anti-depressants work becuase they act as an anti- histime. in SF > Is it true that part of the reason anti-depressants can help is that > serotonin reduces Substance P? > Alison Quote Link to comment Share on other sites More sharing options...
Guest guest Posted May 9, 2001 Report Share Posted May 9, 2001 I have not heard that however wonder if there might be something to it. I do know that elavil is supposed to help VV over a period of time with increasing dosage. However it works immediately for me (within hours ) Unfortunately it works so well even in small doses that it leaves me rather zonked out so I rarely take it. Ora >I have heard anti-depressants work becuase they act as an anti- >histime. > in SF > Quote Link to comment Share on other sites More sharing options...
Guest guest Posted May 9, 2001 Report Share Posted May 9, 2001 > Is it true that part of the reason anti-depressants can help is that > serotonin reduces Substance P? > Alison Alison, As far as I know tricyclic antidepresents like zolof, elivil and prozac block pain impulses from reaching the central nervous system so we don't preceive the pain. I'n unsure why right now and brain fog prevents me from thinking it through. It's a good thing final exams are through :-) Maybe my brain is just tired. Blessings, Shirley. Quote Link to comment Share on other sites More sharing options...
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