Some antibiotics make herpes strains grow

[Guest guest]

Interesting. My kids had lots of amoxicillin in their first couple of years of

life.

Love and prayers,

Heidi N

Eur J Dermatol. 2010 Jan-Feb;20(1):68-73. Epub 2009 Oct 12.

Amoxicillin-induced flare in patients with DRESS (Drug Reaction with

Eosinophilia and Systemic Symptoms): report of seven cases and

demonstration of a direct effect of amoxicillin on Human Herpesvirus 6

replication in vitro.

Mardivirin L, Valeyrie-Allanore L, Branlant-Redon E, Beneton N, Jidar K,

Barbaud A, Crickx B, Ranger-Rogez S, Descamps V.

Department of Virology, Centre Hospitalier Universitaire Dupuytren,

Limoges, France.

Abstract

Amoxicillin is known to induce exanthema in patients with EBV-induced

infectious mononucleosis. It is widely recognized that the reactivation

of herpesviruses, including HHV-6 (Human Herpesvirus 6) and EBV (Epstein

Barr virus) is associated with DRESS (Drug Reaction with Eosinophilia

and Systemic Symptoms). We report 7 cases of amoxicillin-induced flare

in patients with DRESS induced by other drugs and investigate whether

amoxicillin may have a direct effect on HHV-6 replication in vitro. 7

cases of DRESS with amoxicillin-induced flare were retrospectively

analysed. The influence of amoxicillin on HHV-6 HST strain replication

was studied in vitro in a human T lymphoblastoid MT4 cell line. The

viral replication was quantified by immunofluorescence assay and by

real-time polymerase chain reaction (PCR). Comparisons were performed

using the Student's t test. Amoxicillin-induced flare was observed in 7

patients with DRESS induced by other drugs. In two cases HHV-6

reactivation was studied and was demonstrated by PCR. Amoxicillin

neither modified cell viability nor cell proliferation for the range of

tested concentrations.

Amoxicillin increased the replication of HHV-6 at 25 microg*mL-1 and 50

microg*mL-1. Amoxicillin may induce a flare of DRESS, possibly by acting

directly on herpesvirus replication.

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