RE: bruising & fatigue - some thoughts

July 6, 2002

I agree with you about the difficulty of drawing conclusions that

things are IgAN-related.

I don't bruise easily either. I think that for those who do, if it is truly

related to the IgAN, it may be because their IgAN has more elements of HSP

involved. Bruising is more of an HSP symptom (easy breakage or leaking of

tiny blood vessels near the skin). As we know, IgAN and HSP seem to be

different manifestations of the same disease. Probably, nobody is 100% IgAN

or 100% HSP. We all exist on a continuum between to two, with some of us

leaning more towards one than the other. Could be the reason for the fatigue

factor in mild IgAN as well. IgAN describes the specific disease process in

the kidneys, but HSP is a systemic disease which affects the whole body.

Interestingly, the more I think about it, the more I remember being about 8

or 9 years old, and my legs being literally covered with bruises. This was

way beyond anything I ever saw on any of my friends. Late 50's, early

1960's - nobody would have thought anything of it. Plus, few people had

health insurance in those days, and there was no medicare system yet. So,

who knows? I do remember having some pretty wicked episodes of what were

thought to be flus at the time. I wonder how many of us who developed IgAN

in early adulthood actually may have had some degree of undiagnosed HSP long

before actual kidney symptoms became noticeable. Like I said, who would have

thought of HSP in the 1950's and 60's, unless it was very obvious.

Pierre

bruising

>

> > Hi ,

> >

> > Sorry about your diagnosis. A protein level of +3 isn't the best of

news.

> My protein level has been as high as 10 grams (10,000 mg)in 24 hours, but

is

> now back down to my baseline of 1500 mg. There are treatments which your

> Neph will probably discuss with you that can help in reducing the protein

> level.

> >

> > On the bruising, I don't know if it is an official symptom of IgA, but I

> know that I bruise very easily.

> >

July 6, 2002

HSP?

bruising

> >

> > > Hi ,

> > >

> > > Sorry about your diagnosis. A protein level of +3 isn't the best of

> news.

> > My protein level has been as high as 10 grams (10,000 mg)in 24 hours,

but

> is

> > now back down to my baseline of 1500 mg. There are treatments which

your

> > Neph will probably discuss with you that can help in reducing the

protein

> > level.

> > >

> > > On the bruising, I don't know if it is an official symptom of IgA, but

I

> > know that I bruise very easily.

> > >

July 6, 2002

See Henoch-Schonlein purpura

http://www.igan.ca/id35.htm

Pierre

bruising

> > >

> > > > Hi ,

> > > >

> > > > Sorry about your diagnosis. A protein level of +3 isn't the best of

> > news.

> > > My protein level has been as high as 10 grams (10,000 mg)in 24 hours,

> but

> > is

> > > now back down to my baseline of 1500 mg. There are treatments which

> your

> > > Neph will probably discuss with you that can help in reducing the

> protein

> > > level.

> > > >

> > > > On the bruising, I don't know if it is an official symptom of IgA,

but

> I

> > > know that I bruise very easily.

> > > >

July 6, 2002

ty

bruising

> > > >

> > > > > Hi ,

> > > > >

> > > > > Sorry about your diagnosis. A protein level of +3 isn't the best

of

> > > news.

> > > > My protein level has been as high as 10 grams (10,000 mg)in 24

hours,

> > but

> > > is

> > > > now back down to my baseline of 1500 mg. There are treatments which

> > your

> > > > Neph will probably discuss with you that can help in reducing the

> > protein

> > > > level.

> > > > >

> > > > > On the bruising, I don't know if it is an official symptom of IgA,

> but

> > I

> > > > know that I bruise very easily.

> > > > >

July 6, 2002

yw

bruising

> > > > >

> > > > > > Hi ,

> > > > > >

> > > > > > Sorry about your diagnosis. A protein level of +3 isn't the

best

> of

> > > > news.

> > > > > My protein level has been as high as 10 grams (10,000 mg)in 24

> hours,

> > > but

> > > > is

> > > > > now back down to my baseline of 1500 mg. There are treatments

which

> > > your

> > > > > Neph will probably discuss with you that can help in reducing the

> > > protein

> > > > > level.

> > > > > >

> > > > > > On the bruising, I don't know if it is an official symptom of

IgA,

> > but

> > > I

> > > > > know that I bruise very easily.

> > > > > >

July 8, 2002

I second these comments.

I also often need antibiotics due to the reaction I have to insect bites. I

have bruised easily all my life. My five year old daughter was recently

tested for leukaemia due to the severe bruising on her legs - thank god she

tested o.k. Perhaps it is therefore hereditary, I don't know.

Frances Daly

July 8, 2002

Hi Pierre,

Hope you are feeling better.

I agree with your musings I've often wondered if this problem was around

when I was younger. My mother complained to my GP when I was a baby that I

had dark and strong urine, I have always felt pain/bruised more easily than

others I know and

had bouts of puffiness in my face all through my life. I've also reacted

really badly to insect bites and thought it normal until people reacted in

shock when they saw the size of the swellings and blisters.

Sally.

Re: bruising & fatigue - some thoughts

I agree with you about the difficulty of drawing conclusions that

things are IgAN-related.

I don't bruise easily either. I think that for those who do, if it is

truly

related to the IgAN, it may be because their IgAN has more elements of HSP

involved. Bruising is more of an HSP symptom (easy breakage or leaking of

tiny blood vessels near the skin). As we know, IgAN and HSP seem to be

different manifestations of the same disease. Probably, nobody is 100%

IgAN

or 100% HSP. We all exist on a continuum between to two, with some of us

leaning more towards one than the other. Could be the reason for the

fatigue

factor in mild IgAN as well. IgAN describes the specific disease process

in

the kidneys, but HSP is a systemic disease which affects the whole body.

Interestingly, the more I think about it, the more I remember being about

8

or 9 years old, and my legs being literally covered with bruises. This was

way beyond anything I ever saw on any of my friends. Late 50's, early

1960's - nobody would have thought anything of it. Plus, few people had

health insurance in those days, and there was no medicare system yet. So,

who knows? I do remember having some pretty wicked episodes of what were

thought to be flus at the time. I wonder how many of us who developed IgAN

in early adulthood actually may have had some degree of undiagnosed HSP

long

before actual kidney symptoms became noticeable. Like I said, who would

have

thought of HSP in the 1950's and 60's, unless it was very obvious.

Pierre

bruising

>

> > Hi ,

> >

> > Sorry about your diagnosis. A protein level of +3 isn't the best of

news.

> My protein level has been as high as 10 grams (10,000 mg)in 24 hours,

but

is

> now back down to my baseline of 1500 mg. There are treatments which

your

> Neph will probably discuss with you that can help in reducing the

protein

> level.

> >

> > On the bruising, I don't know if it is an official symptom of IgA, but

I

> know that I bruise very easily.

> >

July 8, 2002

By the way, I don't think I mentioned before (maybe someone else already

mentioned it, don't know), but easy bruising can be a side effect of

prednisone. So, if you're on prednisone and have a lot of bruising, that

could be it.

Pierre

July 8, 2002

In the late 60's I had HSP at the age of 4. I had the bruising on the

lower half of my body. The burising is really (at least in my case)

hemmoraging under the skin.(purpura)In fact I was hemmoraging inside

as well.

Margie

> Hi Pierre,

> Hope you are feeling better.

> I agree with your musings I've often wondered if this problem was

around

> when I was younger. My mother complained to my GP when I was a baby

that I

> had dark and strong urine, I have always felt pain/bruised more

easily than

> others I know and

> had bouts of puffiness in my face all through my life. I've also

reacted

> really badly to insect bites and thought it normal until people

reacted in

> shock when they saw the size of the swellings and blisters.

> Sally.

> Re: bruising & fatigue - some thoughts

>

> I agree with you about the difficulty of drawing

conclusions that

> things are IgAN-related.

>

> I don't bruise easily either. I think that for those who do, if

it is

> truly

> related to the IgAN, it may be because their IgAN has more

elements of HSP

> involved. Bruising is more of an HSP symptom (easy breakage or

leaking of

> tiny blood vessels near the skin). As we know, IgAN and HSP seem

to be

> different manifestations of the same disease. Probably, nobody is

100%

> IgAN

> or 100% HSP. We all exist on a continuum between to two, with

some of us

> leaning more towards one than the other. Could be the reason for

the

> fatigue

> factor in mild IgAN as well. IgAN describes the specific disease

process

> in

> the kidneys, but HSP is a systemic disease which affects the

whole body.

>

> Interestingly, the more I think about it, the more I remember

being about

> 8

> or 9 years old, and my legs being literally covered with bruises.

This was

> way beyond anything I ever saw on any of my friends. Late 50's,

early

> 1960's - nobody would have thought anything of it. Plus, few

people had

> health insurance in those days, and there was no medicare system

yet. So,

> who knows? I do remember having some pretty wicked episodes of

what were

> thought to be flus at the time. I wonder how many of us who

developed IgAN

> in early adulthood actually may have had some degree of

undiagnosed HSP

> long

> before actual kidney symptoms became noticeable. Like I said, who

would

> have

> thought of HSP in the 1950's and 60's, unless it was very obvious.

>

> Pierre

>

> bruising

> >

> > > Hi ,

> > >

> > > Sorry about your diagnosis. A protein level of +3 isn't the

best of

> news.

> > My protein level has been as high as 10 grams (10,000 mg)in 24

hours,

> but

> is

> > now back down to my baseline of 1500 mg. There are treatments

which

> your

> > Neph will probably discuss with you that can help in reducing

the

> protein

> > level.

> > >

> > > On the bruising, I don't know if it is an official symptom of

IgA, but

> I

> > know that I bruise very easily.

> > >

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