antibiotic otitis Re: You AhR what you eat: linking diet, intestinal immune function, microbiota

[Guest guest]

Numerous anecdotes from parents of autistic children delineate

excessively recurrent otitis media during the child's first two years

and, correspondingly, numerous rounds of antibiotics. These

retrospective tellings generally include a description of the child's

regression into autism, often accompanied by the development of

persistent gastrointestinal pathology. ~//

Here is an excerpt from Li et al, highlight added:

An altered bacterial composition, but not load, in the absence

of AhR activity was not confined to the small intestine, where the

IEL populations are reduced, but was also observed in the colon.

This results in an accumulation of lymphocytes that show a

predominant type 1 profile characterized by the production of

IFN-g. This is in line with other murine models of colitis that report

a deleterious role of the intestinal microbiota, especially during

the transfer of T cells, and are dominated by a type 1 profile

(Cong et al., 1998). */The direct importance of the microbiota in

the activation of T cells was illustrated when AhR-deficient

mice were treated with a broad-spectrum antibiotic, reducing

both the number of T cells and their activation status/*. Our data

are in also line with observations made in mice genetically engineered

to lack TCRgd lymphocytes, contributing over half of the

intestinal IELs, which are more susceptible to certain bacterial,

protozoal, and viral infections and show increased morbidity

(King et al., 1999; Mombaerts et al., 1993; et al., 2000;

et al., 1996; Selin et al., 2001), and they are in agreement

with increased morbidity of AhR-deficient mice and their increased

susceptibility to colitis and rectal prolapse (Fernandez-

Salguero et al., 1997; Kimura et al., 2009).

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> You AhR what you eat: linking diet and immunity.

> <http://www.ncbi.nlm.nih.gov/pubmed/22036556>

> Hooper LV.

> Cell. 2011 Oct 28;147(3):489-91.

>

> The aryl hydrocarbon receptor (AhR) is responsible for the toxic

> effects of environmental pollutants such as dioxin, but little is

> known about its normal physiological functions. Li et al. (2011) now

> show that specific dietary compounds present in cruciferous vegetables

> act through the AhR to promote intestinal immune function, revealing

> AhR as a critical link between diet and immunity.

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> Comment on

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> Exogenous stimuli maintain intraepithelial lymphocytes via aryl

> hydrocarbon receptor activation.

> <http://www.ncbi.nlm.nih.gov/pubmed/21999944>

> Li Y, Innocentin S, Withers DR, NA, Gallagher AR, Grigorieva

> EF, Wilhelm C, Veldhoen M.

> Cell. 2011 Oct 28;147(3):629-40. Epub 2011 Oct 13.

>

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> PS: Everyone benefits when parents share informative anecdotes. This

> post may be forwarded hither and yon.

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